Search Results - "BETTELLI, E"

Th17: the third member of the effector T cell trilogy by Bettelli, Estelle, Korn, Thomas, Kuchroo, Vijay K

“…T helper responses have now grown to include three T cell subsets: Th1, Th2 and Th17. Th17 cells have recently emerged as a third independent T cell subset…”
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Th17 cells: Effector T cells with inflammatory properties by Korn, Thomas, Oukka, Mohamed, Kuchroo, Vijay, Bettelli, Estelle

“…Abstract Upon activation, naïve CD4+ T cells differentiate into effector T cells with specific effector functions and cytokine profiles. The Th1/Th2 paradigm…”
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Foxp3 Interacts with Nuclear Factor of Activated T Cells and NF-κB to Repress Cytokine Gene Expression and Effector Functions of T Helper Cells by Bettelli, Estelle, Dastrange, Maryam, Oukka, Mohamed, Glimcher, Laurie H.

“…Scurfy mice, which are deficient in a functional Foxp3, exhibit a severe lymphoproliferative disorder and display generalized overproduction of cytokines…”
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Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation by Peters, Anneli, Pitcher, Lisa A., Sullivan, Jenna M., Mitsdoerffer, Meike, Acton, Sophie E., Franz, Bettina, Wucherpfennig, Kai, Turley, Shannon, Carroll, Michael C., Sobel, Raymond A., Bettelli, Estelle, Kuchroo, Vijay K.

“…Ectopic lymphoid follicles are hallmarks of chronic autoimmune inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis, Sjögren's syndrome,…”
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IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together by Bettelli, Estelle, Kuchroo, Vijay K

“…Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23-driven subset of Th cells called…”
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Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis by Bettelli, Estelle, Pagany, Maria, Weiner, Howard L, Linington, Christopher, Sobel, Raymond A, Kuchroo, Vijay K

“…Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic…”
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Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis by Bettelli, Estelle, Sullivan, Brandon, Szabo, Susanne J, Sobel, Raymond A, Glimcher, Laurie H, Kuchroo, Vijay K

“…The transcription factors signal transducer and activator of transcription (STAT)1 and T-bet control the differentiation of interferon (IFN)-gamma-producing T…”
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Clinical significance of serum gastrin levels in patients with colorectal cancer by TOCCHI, A, MAZZONI, G, PUMA, F, MICCINI, M, DADDI, G, BETTELLI, E, CASSINI, D, BROZZETTI, S

“…An association between elevated serum gastrin levels and the presence of human colorectal cancer has been reported, and gastrin has been shown to stimulate the…”
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Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo by Hawiger, Daniel, Masilamani, Revati F, Bettelli, Estelle, Kuchroo, Vijay K, Nussenzweig, Michel C

“…In the steady state, interaction between T cells and antigen-presenting dendritic cells (DCs) leads to T cell tolerance. To examine the role of DC regulated…”
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Impact of axillary level I and II lymphnode dissection on the therapy of stage I and II breast cancer by Tocchi, A, Mazzoni, G, Bettelli, E, Miccini, M, Giuliani, A, Cassini, D

“…Routine performance of axillary node dissection (AND) in the treatment of stage I and II breast cancer has become controversial because of pretended morbidity…”
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T CELL RESPONSE IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE): Role of Self and Cross-Reactive Antigens in Shaping, Tuning, and Regulating the Autopathogenic T Cell Repertoire by Kuchroo, Vijay K, Anderson, Ana C, Waldner, Hanspeter, Munder, Markus, Bettelli, Estelle, Nicholson, Lindsay B

“…T cells that can respond to self-antigens are present in the peripheral immune repertoire of all healthy individuals. Recently we have found that unmanipulated…”
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IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice by Bettelli, Estelle, Prabhu Das, Mercy, Howard, Edward D, Weiner, Howard L, Sobel, Raymond A, Kuchroo, Vijay K

“…Experimental autoimmune encephalomyelitis (EAE) and other organ-specific autoimmune diseases are induced by autoantigen-specific Th1 cells. In contrast,…”
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The dynamics of effector T cells and Foxp3@u+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis by Korn, T, Anderson, A C, Bettelli, E, Oukka, M

“…The Th1/Th2 paradigm of T helper cell subsets had to be revised when IL-17 producing T cells (Th17) were identified as a distinct T helper cell lineage. Th17…”
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T(H)-17 cells in the circle of immunity and autoimmunity by Bettelli, Estelle, Oukka, Mohamed, Kuchroo, Vijay K

“…CD4(+) effector T cells have been categorized into two subsets: T helper type 1 (T(H)1) and T(H)2. Another subset of T cells that produce interleukin 17…”
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Detection of Autoreactive Myelin Proteolipid Protein 139-151-Specific T Cells by Using MHC II (IAs) Tetramers by Reddy, Jayagopala, Bettelli, Estelle, Nicholson, Lindsay, Waldner, Hanspeter, Jang, Mei-Huei, Wucherpfennig, Kai W, Kuchroo, Vijay K

“…Detection of autoreactive T cells using MHC II tetramers is difficult because of the low affinity of their TCR. We have generated a class II tetramer using the…”
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Constitutive Expression of the Costimulatory Molecule CD70 by Non-antigen Specific B Cells is Sufficient to Drive T Cell-driven Autoimmune Disease by Salinas, G F, Cantaert, T, Nolte, M, Bettelli, E, Kuchroo, V, Tak, P P, van Lier, R, Baeten, D

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Inhibition of CTLA-4 Function by the Regulatory Subunit of Serine/Threonine Phosphatase 2A by Baroja, Miren L, Vijayakrishnan, Lalitha, Bettelli, Estelle, Darlington, Peter J, Chau, Thu A, Ling, Vincent, Collins, Mary, Carreno, Beatriz M, Madrenas, Joaquin, Kuchroo, Vijay K

“…The catalytic subunit of the serine/threonine phosphatase 2A (PP2A) can interact with the cytoplasmic tail of CTLA-4. However, the molecular basis and the…”
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IL-21 and TGF- beta are Required for Differentiation of Human Th17 Cells by Anderson, D, Yang, L, Baecher-Allan, C, Bettelli, E, Oukka, M, Kuchroo, V, Hafler, D

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Control of Treg and Th17 Differentiation by AHR by Quintana, F, Basso, A, Iglesias, A, Korn, T, Farez, M, Bettelli, E, Caccamo, M, Oukka, M, Weiner, H

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IL-23 Receptor (IL-23R) GFP Reporter Mice Reveal New Populations of IL-17-producing and IL-23-responsive Cells by Oukka, M, Korn, T, Awasthi, A, Dardalhon, V, Galileos, G, Riol Blanco, L, Kuchroo, V, Bettelli, E

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