Search Results - "BETTAYEB, K"

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases by Bettayeb, K, Oumata, N, Echalier, A, Ferandin, Y, Endicott, J A, Galons, H, Meijer, L

“…Among the ten pharmacological inhibitors of cyclin-dependent kinases (CDKs) currently in clinical trials, the purine roscovitine (CYC202, Seliciclib) is…”
Get full text

Forecasting the Prevalence of Alzheimer’s Disease at Mild Cognitive Impairment and Mild Dementia Stages in France in 2022 by Gabelle, Audrey, Guéry, M., Doutriaux, A., Bettayeb, K.

“…Background Given the evolution of early diagnosis guidelines and future disease-modifying therapies, estimating the prevalence of Alzheimer’s disease (AD) at…”
Get full text

7-Bromoindirubin-3′-oxime induces caspase-independent cell death by RIBAS, J, BETTAYEB, K, SKALTSOUNIS, A.-L, BOIX, J, MEIJER, L, FERANDIN, Y, KNOCKAERT, M, GARROFE-OCHOA, X, TOTZKE, F, SCHÄCHTELE, C, MESTER, J, POLYCHRONOPOULOS, P, MAGIATIS, P

“…Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the…”
Get full text

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells by Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J, Baumli, Sonja, Endicott, Jane A, Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent

“…Neuroblastoma (NB), the most frequent extracranial solid tumor of children accounting for nearly 15% of all childhood cancer mortality, displays overexpression…”
Get full text

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine by Bettayeb, Karima, Sallam, Hatem, Ferandin, Yoan, Popowycz, Florence, Fournet, Guy, Hassan, Moustapha, Echalier, Aude, Bernard, Philippe, Endicott, Jane, Joseph, Benoît, Meijer, Laurent

“…Cyclin-dependent kinases (CDKs) and their regulators show frequent abnormalities in tumors. Ten low molecular weight pharmacologic inhibitors of CDKs are…”
Get full text

Meriolins, a new class of cell death-inducing, cyclin dependent kinase inhibitors with enhanced selectivity for cyclin-dependent kinases by Ferandin O. Lozach J. C. Morris S. Mateo-Lozano P. Drueckes C. Schächtele M. H. G. K. Bettayeb O. M. Tirado S. Marionneau-Lambot, Y.

Get full text