Search Results - "BETHELL, Richard"

Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease by WHITE, Peter W, LLINAS-BRUNET, Montse, KUKOLJ, George, AMAD, Ma'an, BETHELL, Richard C, BOLGER, Gordon, CORDINGLEY, Michael G, JIANMIN DUAN, GARNEAU, Michel, LAGACE, Lisette, THIBEAULT, Diane

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Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication by Vaillancourt, Frédéric H, Pilote, Louise, Cartier, Mireille, Lippens, Julie, Liuzzi, Michel, Bethell, Richard C, Cordingley, Michael G, Kukolj, George

“…Abstract A functional screen of an adenovirus-delivered shRNA library that targets ∼ 4500 host genes was performed to identify cellular factors that regulate…”
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Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor by FENWICK, Craig, AMAD, Ma'an, FADER, Lee D, FAUCHER, Anne-Marie, GARNEAU, Michel, JAKALIAN, Araz, KAWAI, Stephen, LAMORTE, Louie, LAPLANTE, Steven, LAIBIN LUO, MASON, Steve, POUPART, Marc-André, BAILEY, Murray D, RIOUX, Nathalie, SCHROEDER, Patricia, SIMONEAU, Bruno, TREMBLAY, Sonia, TSANTRIZOS, Youla, WITVROUW, Myriam, YOAKIM, Christiane, BETHELL, Richard, BÖS, Michael, BONNEAU, Pierre, CORDINGLEY, Michael, COULOMBE, René, DUAN, Jianmin, EDWARDS, Paul

“…BI 224436 is an HIV-1 integrase inhibitor with effective antiviral activity that acts through a mechanism that is distinct from that of integrase strand…”
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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target by VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen

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Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia by Bankar, Aniket, Siriwardena, Thirushi Piyumika, Rizoska, Biljana, Rydergård, Christina, Kylefjord, Helen, Rraklli, Vilma, Eneroth, Anders, Pinho, Pedro, Norin, Stefan, Bylund, Johan, Moses, Sara, Bethell, Richard, Kavanagh, Simon, Maclean, Neil, Gronda, Marcela, Wang, Xiaoming, Hurren, Rose, Minden, Mark D, Targett-Adams, Paul, Schimmer, Aaron D, Albertella, Mark

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CD160 isoforms and regulation of CD4 and CD8 T-cell responses by El-Far, Mohamed, Pellerin, Charles, Pilote, Louise, Fortin, Jean-Francois, Lessard, Ivan A D, Peretz, Yoav, Wardrop, Elizabeth, Salois, Patrick, Bethell, Richard C, Cordingley, Michael G, Kukolj, George

“…Coexpression of CD160 and PD-1 on HIV-specific CD8+ T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and…”
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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly by Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane

“…The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the…”
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Evidence for Zanamivir Resistance in an Immunocompromised Child Infected with Influenza B Virus by Gubareva, Larisa V., Matrosovich, Mikhail N., Brenner, Malcolm K., Bethell, Richard C., Webster, Robert G.

“…Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza. During prolonged treatment with zanamivir, a mutant virus was isolated…”
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Viral Resistance in Hepatitis C Virus Genotype 1-Infected Patients Receiving the NS3 Protease Inhibitor Faldaprevir (BI 201335) in a Phase 1b Multiple-Rising-Dose Study by BERGER, Kristi L, LAGACE, Lisette, TRIKI, Ibtissem, CARTIER, Mireille, MARQUIS, Martin, LAWETZ, Carol, BETHELL, Richard, SCHERER, Joseph, KUKOLJ, George

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The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans by JIANMIN DUAN, BOLGER, Gordon, KUKOLJ, George, WHITE, Peter W, BETHELL, Richard C, CORDINGLEY, Michael G, GARNEAU, Michel, AMAD, Ma'an, BATONGA, Joëlle, MONTPETIT, Hélène, OTIS, François, JUTRAS, Martin, LAPEYRE, Nicole, RHEAUME, Manon

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition by Wang, Meitian, Ng, Kenneth K-S, Cherney, Maia M, Chan, Laval, Yannopoulos, Constantin G, Bedard, Jean, Morin, Nicolas, Nguyen-Ba, Nghe, Alaoui-Ismaili, Moulay H, Bethell, Richard C, James, Michael N G

“…X-ray crystal structures of two non-nucleoside analogue inhibitors bound to hepatitis C virus NS5B RNA-dependent RNA polymerase have been determined to 2.0 and…”
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Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents by Draffan, Alistair G., Frey, Barbara, Fraser, Benjamin H., Pool, Brett, Gannon, Carlie, Tyndall, Edward M., Cianci, Julia, Harding, Michael, Lilly, Michael, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Jeynes, Tyrone P., Nguyen, Van T.T., Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Pryor, Melinda, Porter, Kate, Morton, Craig J., Lin, Bo, Duan, Jianmin, Bethell, Richard C., Kukolj, George, Simoneau, Bruno, Tucker, Simon P.

“…[Display omitted] Previous investigations identified 2′-C-Me-branched ribo-C-nucleoside adenosine analogues, 1, which contains a…”
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Discovery and Synthesis of C‑Nucleosides as Potential New Anti-HCV Agents by Draffan, Alistair G, Frey, Barbara, Pool, Brett, Gannon, Carlie, Tyndall, Edward M, Lilly, Michael, Francom, Paula, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Nguyen, Van T. T, Jeynes, Tyrone P, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse D, Pryor, Melinda, Porter, Kate, Morton, Craig J, Lin, Bo, Duan, Jianmin, Kukolj, George, Simoneau, Bruno, McKercher, Ginette, Lagacé, Lisette, Amad, Ma’an, Bethell, Richard C, Tucker, Simon P

“…Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antivirals (DAAs) to treat hepatitis C virus because they have…”
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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors by Tremblay, Martin, Bethell, Richard C., Cordingley, Michael G., DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Edwards, Paul J., Faucher, Anne-Marie, Halmos, Ted, James, Clint A., Kuhn, Cyrille, Lacoste, Jean-Éric, Lamorte, Louie, LaPlante, Steven R., Malenfant, Éric, Minville, Joannie, Morency, Louis, Morin, Sébastien, Rajotte, Daniel, Salois, Patrick, Simoneau, Bruno, Tremblay, Sonia, Sturino, Claudio F.

“…Screening of our sample collection led to the identification of a set of benzofurano[3,2-d]pyrimidine-2-one hits acting as nucleotide-competing HIV-1 reverse…”
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A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data by Rioux, Nathalie, Batonga, Joëlle, Colombo, Federico, Massé, Jonathan, Zouki, Christine, Ribadeneira, Maria D., Duan, Jianmin, Bethell, Richard C.

“…Abstract 1. The present study evaluates which factors should be incorporated into a simplified approach to reasonably predict CYP3A-mediated drug-drug…”
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Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients by CAHN, Pedro, CASSETTI, Isabel, WOOD, Robin, PHANUPHAK, Praphan, SHIVELEY, Leeann, BETHELL, Richard C, SAWYER, James

“…Apricitabine (formerly AVX754 and SPD754) is a deoxycytidine analogue nucleoside reverse transcriptase inhibitor in clinical development for patients with HIV…”
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Characterization of Influenza A/HongKong/156/97 (H5N1) Virus in a Mouse Model and Protective Effect of Zanamivir on H5N1 Infection in Mice by Gubareva, Larisa V., McCullers, Jonathan A., Bethell, Richard C., Webster, Robert G.

“…A recent outbreak of influenza in Hong Kong was caused by a highly virulent virus of avian origin. Concern that the appearance of such a virus in the human…”
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Rational design of potent sialidase-based inhibitors of influenza virus replication by von Itzstein, Mark, Wu, Wen-Yang, Kok, Gaik B, Pegg, Michael S, Dyason, Jeffrey C, Jin, Betty, Phan, Tho Van, Smythe, Mark L, White, Hume F, Oliver, Stuart W, Colman, Peter M, Varghese, Joseph N, Ryan, D. Michael, Woods, Jacqueline M, Bethell, Richard C, Hotham, Vanessa J, Cameron, Janet M, Penn, Charles R

“…Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the…”
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Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor by Duan, Jianmin, Yong, Chan-Loi, Garneau, Michel, Amad, Ma'an, Bolger, Gordon, De Marte, Josie, Montpetit, Hélène, Otis, Francois, Jutras, Martin, Rhéaume, Manon, White, Peter W., Llinàs-Brunet, Montse, Bethell, Richard C., Cordingley, Michael G.

“…The present study describes the cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV protease inhibitor currently…”
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Dihydropyrancarboxamides Related to Zanamivir:  A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides by Smith, Paul W, Sollis, Steven L, Howes, Peter D, Cherry, Peter C, Starkey, Ian D, Cobley, Kevin N, Weston, Helen, Scicinski, Jan, Merritt, Andrew, Whittington, Andrew, Wyatt, Paul, Taylor, Neil, Green, Darren, Bethell, Richard, Madar, Safia, Fenton, Robert J, Morley, Peter J, Pateman, Tony, Beresford, Alan

“…4-Amino- and 4-guanidino-4H-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases…”
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