Search Results - "BETH GENTER, Mary"

The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5 by FANG XIE, XIN ZHOU, BETH GENTER, Mary, BEHR, Melissa, JUN GU, XINXIN DING

“…The antithyroid drug methimazole (MMZ) can cause severe, tissue-specific toxicity in mouse olfactory mucosa (OM), presumably through a sequential metabolic…”
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Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease by Bermúdez, Mei-Ling, Seroogy, Kim B., Genter, Mary Beth

“…Parkinson disease (PD) is a leading neurodegenerative disease, with multifaceted interacting mechanisms. The Thy1-aSyn mouse model of PD exhibits many features…”
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An Update on Sphingosine-1-Phosphate and Lysophosphatidic Acid Receptor Transcripts in Rodent Olfactory Mucosa by Toebbe, J T, Genter, Mary Beth

“…Olfactory neurons connect the external environment and the brain, allowing the translocation of materials from the nasal cavity into the brain. The olfactory…”
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Distribution and Systemic Effects of Intranasally Administered 25 nm Silver Nanoparticles in Adult Mice by Genter, Mary Beth, Newman, Nicholas C., Shertzer, Howard G., Ali, Syed F., Bolon, Brad

“…Previous work indicates that silver nanoparticles (AgNPs) given IP to mice alter the regulation of inflammation- and oxidative stress–related genes in brain…”
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Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet by Shertzer, Howard G, Woods, Sally E, Krishan, Mansi, Genter, Mary Beth, Pearson, Kevin J

“…Consuming a high-fat (HF) diet produces excessive weight gain, adiposity, and metabolic complications associated with risk for developing type 2 diabetes and…”
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Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice by Hsieh, Heidi, Horwath, Michael C., Genter, Mary Beth

“…•Zinc gluconate (ZG) causes olfactory damage in wild-type and MT KO mice.•Clinically-relevant concentration of ZG (33mM) causes olfactory damage in mice.•MT…”
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Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora by Hsieh, Heidi, Vignesh, Kavitha Subramanian, Deepe, Jr, George S, Choubey, Divaker, Shertzer, Howard G, Genter, Mary Beth

“…Zinc is both an essential and potentially toxic metal. It is widely believed that oral zinc supplementation can reduce the effects of the common cold; however,…”
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Lipid metabolism and body composition in Gclm(−/−) mice by Kendig, Eric L., Chen, Ying, Krishan, Mansi, Johansson, Elisabet, Schneider, Scott N., Genter, Mary Beth, Nebert, Daniel W., Shertzer, Howard G.

“…In humans and experimental animals, high fat diets (HFD) are associated with risk factors for metabolic diseases, such as excessive weight gain and adiposity,…”
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Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice by Sasso, Alan F, Schlosser, Paul M, Kedderis, Gregory L, Genter, Mary Beth, Snawder, John E, Li, Zheng, Rieth, Susan, Lipscomb, John C

“…Physiologically based pharmacokinetic (PBPK) models are tools for interpreting toxicological data and extrapolating observations across species and route of…”
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Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain by Krishan, Mansi, Gudelsky, Gary A, Desai, Pankaj B, Genter, Mary Beth

“…Delivery of drugs from the nasal cavity to the brain is becoming more widely accepted, due to the non-invasive nature of this route and the ability to…”
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Editor’s note by Genter, Mary Beth

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Editor's note by Genter, Mary Beth

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Editor’s note by Genter, Mary Beth

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Editor's note by Genter, Mary Beth

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Editor’s Note by Genter, Mary Beth

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Editor's Note by Genter, Mary Beth

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So…….You Want to be a Peer Reviewer? by Genter, Mary Beth

“…Peer review is essential to preserving the integrity of the scientific publication process. Peer reviewers must adhere to the norms of the peer review process,…”
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Editor’s Note by Genter, Mary Beth

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Regulation of cytochrome P450 gene expression in the olfactory mucosa by Ling, Guoyu, Gu, Jun, Genter, Mary Beth, Zhuo, Xiaoliang, Ding, Xinxin

“…The mammalian olfactory mucosa (OM) is unique among extrahepatic tissues in having high levels, and tissue-selective forms, of cytochrome P450 (CYP) enzymes…”
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Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb: Fig. 1 by Genter, Mary Beth, Krishan, Mansi, Augustine, Lisa M., Cherrington, Nathan J.

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