Search Results - "BETEL, Doron"

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites by Betel, Doron, Koppal, Anjali, Agius, Phaedra, Sander, Chris, Leslie, Christina

“…mirSVR is a new machine learning method for ranking microRNA target sites by a down-regulation score. The algorithm trains a regression model on sequence and…”
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Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use by Kim, Tae Wan, Piao, Jinghua, Koo, So Yeon, Kriks, Sonja, Chung, Sun Young, Betel, Doron, Socci, Nicholas D., Choi, Se Joon, Zabierowski, Susan, Dubose, Brittany N., Hill, Ellen J., Mosharov, Eugene V., Irion, Stefan, Tomishima, Mark J., Tabar, Viviane, Studer, Lorenz

“…Human pluripotent stem cells show considerable promise for applications in regenerative medicine, including the development of cell replacement paradigms for…”
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Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA by Chandran, Smita S., Ma, Jiaqi, Klatt, Martin G., Dündar, Friederike, Bandlamudi, Chaitanya, Razavi, Pedram, Wen, Hannah Y., Weigelt, Britta, Zumbo, Paul, Fu, Si Ning, Banks, Lauren B., Yi, Fei, Vercher, Enric, Etxeberria, Inaki, Bestman, Watchain D., Da Cruz Paula, Arnaud, Aricescu, Ilinca S., Drilon, Alexander, Betel, Doron, Scheinberg, David A., Baker, Brian M., Klebanoff, Christopher A.

“…Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a…”
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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs by Cornacchia, Daniela, Zhang, Chao, Zimmer, Bastian, Chung, Sun Young, Fan, Yujie, Soliman, Mohamed A., Tchieu, Jason, Chambers, Stuart M., Shah, Hardik, Paull, Daniel, Konrad, Csaba, Vincendeau, Michelle, Noggle, Scott A., Manfredi, Giovanni, Finley, Lydia W.S., Cross, Justin R., Betel, Doron, Studer, Lorenz

“…Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain…”
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Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas by Mu, Ping, Han, Yoon-Chi, Betel, Doron, Yao, Evelyn, Squatrito, Massimo, Ogrodowski, Paul, de Stanchina, Elisa, D'Andrea, Aleco, Sander, Chris, Ventura, Andrea

“…The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron…”
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Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response by Lipchina, Inna, Elkabetz, Yechiel, Hafner, Markus, Sheridan, Robert, Mihailovic, Aleksandra, Tuschl, Thomas, Sander, Chris, Studer, Lorenz, Betel, Doron

“…MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency…”
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Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs by Leslie, Christina S, Marks, Debora S, Khan, Aly A, Betel, Doron, Miller, Martin L, Sander, Chris

“…Transfection of siRNAs and miRNAs into cells has been observed to generate unexpected effects in the form of gene upregulation. By statistically analyzing…”
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Widespread regulatory activity of vertebrate microRNA species by Yang, Jr-Shiuan, Phillips, Michael D, Betel, Doron, Mu, Ping, Ventura, Andrea, Siepel, Adam C, Chen, Kevin C, Lai, Eric C

“…An obligate intermediate during microRNA (miRNA) biogenesis is an ~22-nucleotide RNA duplex, from which the mature miRNA is preferentially incorporated into a…”
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Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB by Rajasethupathy, Priyamvada, Fiumara, Ferdinando, Sheridan, Robert, Betel, Doron, Puthanveettil, Sathyanarayanan V., Russo, James J., Sander, Chris, Tuschl, Thomas, Kandel, Eric

“…Memory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regulatory…”
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Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration by Xia, Yu, Duca, Sierra, Perder, Björn, Dündar, Friederike, Zumbo, Paul, Qiu, Miaoyan, Yao, Jun, Cao, Yingxi, Harrison, Michael R. M., Zangi, Lior, Betel, Doron, Cao, Jingli

“…The epicardium, a mesothelial cell tissue that encompasses vertebrate hearts, supports heart regeneration after injury through paracrine effects and as a…”
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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo by La Rocca, Gaspare, King, Bryan, Shui, Bing, Li, Xiaoyi, Zhang, Minsi, Akat, Kemal M, Ogrodowski, Paul, Mastroleo, Chiara, Chen, Kevin, Cavalieri, Vincenzo, Ma, Yilun, Anelli, Viviana, Betel, Doron, Vidigal, Joana, Tuschl, Thomas, Meister, Gunter, Thompson, Craig B, Lindsten, Tullia, Haigis, Kevin, Ventura, Andrea

“…Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue…”
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The expanding role of miR-302-367 in pluripotency and reprogramming by Lipchina, Inna, Studer, Lorenz, Betel, Doron

“…MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete…”
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Unifying cancer and normal RNA sequencing data from different sources by Wang, Qingguo, Armenia, Joshua, Zhang, Chao, Penson, Alexander V., Reznik, Ed, Zhang, Liguo, Minet, Thais, Ochoa, Angelica, Gross, Benjamin E., Iacobuzio-Donahue, Christine A., Betel, Doron, Taylor, Barry S., Gao, Jianjiong, Schultz, Nikolaus

“…Driven by the recent advances of next generation sequencing (NGS) technologies and an urgent need to decode complex human diseases, a multitude of large-scale…”
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Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma by Correa-Gallego, Camilo, Maddalo, Danilo, Doussot, Alexandre, Kemeny, Nancy, Kingham, T Peter, Allen, Peter J, D'Angelica, Michael I, DeMatteo, Ronald P, Betel, Doron, Klimstra, David, Jarnagin, William R, Ventura, Andrea

“…MicroRNAs (miRNAs) are potential biomarkers in various malignancies. We aim to characterize miRNA expression in intrahepatic cholangiocarcinoma (ICC) and…”
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531 by Au, CheukMan C, Furness, John B, Britt, Kara, Oshchepkova, Sofya, Ladumor, Heta, Soo, Kai Ying, Callaghan, Brid, Gerard, Celine, Inghirami, Giorgio, Mittal, Vivek, Wang, Yufeng, Huang, Xin Yun, Spector, Jason A, Andreopoulou, Eleni, Zumbo, Paul, Betel, Doron, Dow, Lukas, Brown, Kristy A

“…Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second leading cause of cancer-related…”
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Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease by Guttikonda, Sudha R., Sikkema, Lisa, Tchieu, Jason, Saurat, Nathalie, Walsh, Ryan M., Harschnitz, Oliver, Ciceri, Gabriele, Sneeboer, Marjolein, Mazutis, Linas, Setty, Manu, Zumbo, Paul, Betel, Doron, de Witte, Lot D., Pe’er, Dana, Studer, Lorenz

“…Aberrant inflammation in the CNS has been implicated as a major player in the pathogenesis of human neurodegenerative disease. We developed a new approach to…”
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SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing by Redin, Esther, Sridhar, Harsha, Zhan, Yingqian A, Pereira Mello, Barbara, Zhong, Hong, Durani, Vidushi, Sabet, Amin, Manoj, Parvathy, Linkov, Irina, Qiu, Juan, Koche, Richard P, de Stanchina, Elisa, Astorkia, Maider, Betel, Doron, Quintanal-Villalonga, Álvaro, Rudin, Charles M

“…Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence…”
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Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing by Redin, Esther, Sridhar, Harsha, Zhan, Yingqian A, Pereira Mello, Barbara, Zhong, Hong, Durani, Vidushi, Sabet, Amin, Manoj, Parvathy, Linkov, Irina, Qiu, Juan, Koche, Richard P, de Stanchina, Elisa, Astorkia, Maider, Betel, Doron, Quintanal-Villalonga, Álvaro, Rudin, Charles M

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The Gastric Microbiome and Its Influence on Gastric Carcinogenesis by Zhang, Chao, PhD, Powell, Sarah Ellen, PhD, Betel, Doron, PhD, Shah, Manish A., MD

“…Gastric malignancies are a leading cause of cancer-related death worldwide. At least 2 microbial species are currently linked to carcinogenesis and the…”
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"Same difference": comprehensive evaluation of four DNA methylation measurement platforms by Kacmarczyk, Thadeous J, Fall, Mame P, Zhang, Xihui, Xin, Yuan, Li, Yushan, Alonso, Alicia, Betel, Doron

“…DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are…”
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