Search Results - "BESSMAN, M. J"

The Nudix hydrolases of Deinococcus radiodurans by Xu, WenLian, Shen, JianYing, Dunn, Christopher A., Desai, Seema, Bessman, Maurice J.

“…All 21 of the Nudix hydrolase genes from the radiation‐resistant organism Deinococcus radiodurans have been cloned into vectors under the control of T7…”
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Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase by Bhatnagar, S K, Bessman, M J

“…The mutator gene, mutT, has been cloned into an expression vector and overproduced in Escherichia coli. The gene product has been purified to over 90%…”
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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology by Scharenberg, Andrew M, Perraud, Anne-Laure, Fleig, Andrea, Dunn, Christopher A, Bagley, Leigh Ann, Launay, Pierre, Schmitz, Carsten, Stokes, Alexander J, Zhu, Qiqin, Bessman, Maurice J, Penner, Reinhold, Kinet, Jean-Pierre

“…Free ADP-ribose (ADPR), a product of NAD hydrolysis and a breakdown product of the calcium-release second messenger cyclic ADPR (cADPR), has no defined role as…”
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Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes by FRICK, D. N, WEBER, D. J, GILLESPIE, J. R, BESSMAN, M. J, MILDVAN, A. S

“…Kinetic analyses of both the Mn(2+)- and Mg(2+)-activated hydrolysis of dGTP by MutT show the requirement for two divalent cations. Whereas Mn2+ supports a…”
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The MutT Proteins or “Nudix” Hydrolases, a Family of Versatile, Widely Distributed, “Housecleaning” Enzymes by Bessman, Maurice J., Frick, David N., O'Handley, Suzanne F.

“…Our studies on the biochemical basis of spontaneous mutations took an interesting and unexpected turn when we discovered that a small region of amino acid…”
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Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity by BULLIONS, L. C, MEJEAN, V, CLAVERYS, J.-P, BESSMAN, M. J

“…The mutX gene of Streptococcus pneumoniae, a homologue of the Escherichia coli mutT mutator gene (Méjean, V., Salles, C., Bullions, L. C., Bessman, M. J., and…”
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dGTP triphosphohydrolase, a unique enzyme confined to members of the family Enterobacteriaceae by QUIRK, S, BESSMAN, M. J

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The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from Escherichia coli by Seto, D, Bhatnagar, S K, Bessman, M J

“…Deoxyguanosine triphosphate (dGTP) triphosphohydrolase (EC 3.1.5.1) has been purified approximately 16,000-fold to apparent homogeneity from extracts of…”
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Characterization of the mutT nucleoside triphosphatase of Escherichia coli by Bhatnagar, S K, Bullions, L C, Bessman, M J

“…The mutT protein, which prevents A:T---C:G transversions during DNA replication, has the following enzymatic properties. Although it prefers dGTP as a…”
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Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP by Teplyakov, A., Sebastiao, P., Obmolova, G., Perrakis, A., Brush, G. S., Bessman, M. J., Wilson, K. S.

“…NMP kinases catalyse the phosphorylation of the canonical nucleotides to the corresponding diphosphates using ATP as a phosphate donor. Bacteriophage T4…”
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The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family by Amzel, L. Mario, Gabelli, Sandra B, Bianchet, Mario A, Bessman, Maurice J

“…Regulation of cellular levels of ADP-ribose is important in preventing nonenzymatic ADP-ribosylation of proteins. The Escherichia coli ADP-ribose…”
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Studies on the ADP-ribose Pyrophosphatase Subfamily of the Nudix Hydrolases and Tentative Identification of trgB, a Gene Associated with Tellurite Resistance by Dunn, Christopher A., O'Handley, Suzanne F., Frick, David N., Bessman, Maurice J.

“…Four Nudix hydrolase genes, ysa1 fromSaccharomyces cerevisiae, orf209 fromEscherichia coli, yqkg from Bacillus subtilis, and hi0398 from Hemophilus influenzae…”
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The interaction of DNA polymerase III and the product of the Escherichia coli mutator gene, mutD by DiFrancesco, R, Bhatnagar, S K, Brown, A, Bessman, M J

“…A comparison of DNA polymerase III core enzyme (McHenry, C. S., and Crow, W. (1979) J. Biol. Chem. 254, 1748-1753) prepared from wild type Escherichia coli and…”
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Secondary structure of the MutT enzyme as determined by NMR by Weber, David J., Abeygunawardana, Chitrananda, Bessman, Maurice J., Mildvan, Albert S.

“…The MutT enzyme (129 amino acids) catalyzes the hydrolysis of nucleoside triphosphates (NTP) to nucleotides (NMP) and pyrophosphate by nucleophilic…”
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Chemical modification of bacteriophage T4 deoxynucleotide kinase. Evidence of a single catalytic region by BRUSH, G. S, BESSMAN, M. J

“…The mechanism underlying the unusual specificity of bacteriophage T4 deoxynucleotide kinase, which catalyzes the phosphorylation of…”
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Biochemical studies on the mutagen, 6-N-hydroxylaminopurine. Synthesis of the deoxynucleoside triphosphate and its incorporation into DNA in vitro by Abdul-Masih, M T, Bessman, M J

“…The nucleotide analogue, 6-N-hydroxylaminopurine deoxynucleoside triphosphate (dHAPTP) has been synthesized from 6-chloropurine by a procedure involving both…”
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NMR and isotopic exchange studies of the site of bond cleavage in the MutT reaction by Weber, D J, Bhatnagar, S K, Bullions, L C, Bessman, M J, Mildvan, A S

“…The MutT protein, which prevents AT---CG transversions during DNA replication, hydrolyzes nucleoside triphosphates to yield nucleoside monophosphates and…”
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Bacteriophage T4 deoxynucleotide kinase: gene cloning and enzyme purification by BRUSH, G. S, BHATNAGAR, S. K, BESSMAN, M. J

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The gene, ialA, associated with the invasion of human erythrocytes by Bartonella bacilliformis, designates a nudix hydrolase active on dinucleoside 5'-polyphosphates by Conyers, G B, Bessman, M J

“…ialA, one of two genes associated with the invasion of human red blood cells by Bartonella bacilliformis, the causative agent of several diseases, has been…”
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Characterization of the defect in the Escherichia coli mutT1 mutator gene by BHATNAGAR, S. K, BULLIONS, L. C, LEW, G, BESSMAN, M. J

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