Search Results - "BESSES, CARLES"

Effect of Mutation Order on Myeloproliferative Neoplasms by Ortmann, Christina A, Kent, David G, Nangalia, Jyoti, Silber, Yvonne, Wedge, David C, Grinfeld, Jacob, Baxter, E. Joanna, Massie, Charles E, Papaemmanuil, Elli, Menon, Suraj, Godfrey, Anna L, Dimitropoulou, Danai, Guglielmelli, Paola, Bellosillo, Beatriz, Besses, Carles, Döhner, Konstanze, Harrison, Claire N, Vassiliou, George S, Vannucchi, Alessandro, Campbell, Peter J, Green, Anthony R

“…About 10% of myeloproliferative neoplasms carry mutations in both TET2 and JAK2 . Clinical presentation, risk of thrombosis, and rates of tumor progression are…”
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Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera by Alvarez-Larrán, Alberto, Pereira, Arturo, Cervantes, Francisco, Arellano-Rodrigo, Eduardo, Hernández-Boluda, Juan-Carlos, Ferrer-Marín, Francisca, Angona, Anna, Gómez, Montse, Muiña, Begoña, Guillén, Helga, Teruel, Anabel, Bellosillo, Beatriz, Burgaleta, Carmen, Vicente, Vicente, Besses, Carles

“…Criteria of response and definition of resistance and intolerance to hydroxyurea (HU) in polycythemia vera (PV) were proposed by the European LeukemiaNet…”
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Hematological disorders: a commonly unrecognized cause of acute stroke by Arboix, Adrià, Jiménez, Carme, Massons, Joan, Parra, Olga, Besses, Carles

“…Hematological disorders account for about 1.3% of all causes of acute stroke. This systematized review presents updated information on the implications of this…”
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Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated by Martínez-Calle, Nicolás, Pascual, Marien, Ordoñez, Raquel, Enériz, Edurne San José, Kulis, Marta, Miranda, Estíbaliz, Guruceaga, Elisabeth, Segura, Víctor, Larráyoz, María José, Bellosillo, Beatriz, Calasanz, María José, Besses, Carles, Rifón, José, Martín-Subero, José I, Agirre, Xabier, Prosper, Felipe

“…In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially…”
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The International Prognostic Scoring System does not accurately discriminate different risk categories in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis by Hernández-Boluda, Juan-Carlos, Pereira, Arturo, Gómez, Montse, Boqué, Concepción, Ferrer-Marín, Francisca, Raya, José-María, García-Gutiérrez, Valentín, Kerguelen, Ana, Xicoy, Blanca, Barba, Pere, Martínez, Jesús, Luño, Elisa, Alvarez-Larrán, Alberto, Martínez-López, Joaquín, Arbelo, Elisa, Besses, Carles

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Clinical evaluation of the European LeukaemiaNet criteria for clinicohaematological response and resistance/intolerance to hydroxycarbamide in essential thrombocythaemia by Hernández‐Boluda, Juan‐Carlos, Alvarez‐Larrán, Alberto, Gómez, Montse, Angona, Anna, Amat, Paula, Bellosillo, Beatriz, Martínez‐Avilés, Luz, Navarro, Blanca, Teruel, Anabel, Martínez‐Ruiz, Francisco, Besses, Carles

“…Summary Standardized criteria of response to treatment and a unified definition of resistance/intolerance to hydroxycarbamide (HC) in essential…”
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Pemphigus‐like hypereosinophilic syndrome with FIP1L1–PDGFRA fusion gene: A challenging and uncommon clinical presentation by Curto‐Barredo, Laia, Segura, Sonia, Ishii, Norito, Hashimoto, Takashi, Mascaró, José M., Espinet, Blanca, Besses, Carles, Pujol, Ramon M.

“…Hypereosinophilic syndrome (HES) is often associated with cutaneous manifestations, mostly pruritic lesions, urticaria and angioedema. Mucosal lesions are…”
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Study of regulatory T-cells in patients with gastric malt lymphoma: influence on treatment response and outcome by García, Mar, Bellosillo, Beatriz, Sánchez-González, Blanca, García-Payarols, Francesc, Seoane, Agustin, Ferrer, Ana Maria, Gimeno, Eva, Barranco, Luis Eugenio, Torner, Ariadna, Solé, Francesc, Besses, Carles, Serrano, Sergi, Salar, Antonio

“…FOXP3+ regulatory T cells (Treg) play an essential role in modulating host responses to tumors and infections. The role of these cells in the pathogenesis of…”
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Aberrant DNA methylation profile of chronic and transformed classic Philadelphia-negative myeloproliferative neoplasms by Pérez, Cristina, Pascual, Marien, Martín-Subero, José Ignacio, Bellosillo, Beatriz, Segura, Victor, Delabesse, Eric, Álvarez, Sara, Larrayoz, María José, Rifón, José, Cigudosa, Juan Cruz, Besses, Carles, Calasanz, María José, Cross, Nicholas C P, Prósper, Felipe, Agirre, Xabier

“…Most DNA methylation studies in classic Philadelphia-negative myeloproliferative neoplasms have been performed on a gene-by-gene basis. Therefore, a more…”
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A polymorphism in the XPD gene predisposes to leukemic transformation and new nonmyeloid malignancies in essential thrombocythemia and polycythemia vera by Hernández-Boluda, Juan-Carlos, Pereira, Arturo, Cervantes, Francisco, Alvarez-Larrán, Alberto, Collado, María, Such, Esperanza, Arilla, M. Jesús, Boqué, Concepción, Xicoy, Blanca, Maffioli, Margherita, Bellosillo, Beatriz, Marugán, Isabel, Amat, Paula, Besses, Carles, Guillem, Vicent

“…Patients with essential thrombocythemia (ET) and polycythemia vera (PV) have an increased incidence of acute myeloid leukemia and new nonhematologic…”
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Rapidly Growing and Aggressive Cutaneous Squamous Cell Carcinomas in a Patient Treated with Ruxolitinib by March-Rodriguez, Álvaro, Bellosillo, Beatriz, Álvarez-Larrán, Alberto, Besses, Carles, Pujol, Ramon M, Toll, Agustí

“…Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or…”
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JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis by Martinez-Aviles, Luz, Besses, Carles, Alvarez-Larran, Alberto, Cervantes, Francisco, Hernandez-Boluda, Juan Carlos, Bellosillo, Beatriz

“…* Departments of Pathology and ° Clinical Hematology Hospital del Mar, IMAS, Barcelona; # Department of Hematology, Hospital Clínic, University of Barcelona; @…”
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FISH is better than BIOMED-2 PCR to detect IgH/ BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections by Espinet, Blanca, Bellosillo, Beatriz, Melero, Carme, Vela, Mª Carmen, Pedro, Carmen, Salido, Marta, Pijuan, Lara, Florensa, Lourdes, Besses, Carles, Serrano, Sergi, Solé, Francesc

“…The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the…”
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Anti-tumor activity of the combination of bendamustine with vorinostat in diffuse large B-cell lymphoma cells by Fernández-Rodríguez, Concepción, Salar, Antonio, Navarro, Alfons, Gimeno, Eva, Pairet, Silvia, Camacho, Laura, Ferraro, Mariana, Serrano, Sergi, Besses, Carles, Bellosillo, Beatriz, Sanchez-Gonzalez, Blanca

“…Current standard-of-care therapy for diffuse large B-cell lymphoma (DLBCL) results in up to 40% of patients who either relapse or develop refractory disease…”
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Characterization of CD34+ hematopoietic progenitor cells in JAK2V617F and CALR-mutated myeloproliferative neoplasms by Angona, Anna, Alvarez-Larrán, Alberto, Bellosillo, Beatriz, Longarón, Raquel, Camacho, Laura, Fernández-Rodríguez, M. Concepción, Pairet, Silvia, Besses, Carles

“…•CALR-mutated ET patients harbored a higher mutant load at progenitor level than JAK2-positive ET.•Hematopoietic stem cells of CALR-mutated ET showed a similar…”
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Primary epidural lymphoma by ALAMEDA, Francesc, PEDRO, Carme, BESSES, Carles, GALITO, Emili, MARINOSO, Maria Luisa, MUNNE, Assumpta, SERRANO, Sergi

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The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia by Espinosa, Lluis, Cathelin, Severine, D'Altri, Teresa, Trimarchi, Thomas, Statnikov, Alexander, Guiu, Jordi, Rodilla, Veronica, Inglés-Esteve, Julia, Nomdedeu, Josep, Bellosillo, Beatriz, Besses, Carles, Abdel-Wahab, Omar, Kucine, Nicole, Sun, Shao-Cong, Song, Guangchan, Mullighan, Charles C., Levine, Ross L., Rajewsky, Klaus, Aifantis, Iannis, Bigas, Anna

“…It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell acute lymphoblastic leukemia (T-ALL). Here, we visualize…”
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Non-driver mutations in patients with JAK2V617F-mutated polycythemia vera or essential thrombocythemia with long-term molecular follow-up by Senín, Alicia, Fernández-Rodríguez, Concepción, Bellosillo, Beatriz, Camacho, Laura, Longarón, Raquel, Angona, Anna, Besses, Carles, Álvarez-Larrán, Alberto

“…JAK2 V617F monitoring and NGS of non-driver genes was performed in 100 patients with polycythemia vera (PV) or essential thrombocythemia (ET) with long…”
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Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations by Passamonti, Francesco, Elena, Chiara, Schnittger, Susanne, Skoda, Radek C., Green, Anthony R., Girodon, François, Kiladjian, Jean-Jacques, McMullin, Mary Frances, Ruggeri, Marco, Besses, Carles, Vannucchi, Alessandro M., Lippert, Eric, Gisslinger, Heinz, Rumi, Elisa, Lehmann, Thomas, Ortmann, Christina A., Pietra, Daniela, Pascutto, Cristiana, Haferlach, Torsten, Cazzola, Mario

“…Although approximately 95% of patients with polycythemia vera (PV) harbor the V617F mutation in JAK2 exon 14, several mutations in exon 12 have been described…”
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Clonal Dynamics of JAK2V617F and Non-Driver Mutations in Polycythemia Vera and Essential Thrombocythemia Patients Receiving Hydroxyurea Therapy by Fernández-Ibarrondo, Lierni, Gibert, Joan, Fernández-Rodríguez, Concepción, Camacho, Laura, Angona, Anna, Andrade, Marcio, Garcia-Gisbert, Nieves, Arenillas, Leonor, Vélez, Patricia, Longarón, Raquel, Diez-Feijoo, Ramon, Salar, Antonio, Besses, Carles, Bellosillo, Beatriz

“…▪ Introduction: Hydroxyurea (HU) is the most widely used cytoreductive treatment for patients with essential thrombocythemia (ET) and polycythemia vera (PV) at…”
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