Search Results - "BERYT, M"

Rational Combinations of Trastuzumab With Chemotherapeutic Drugs Used in the Treatment of Breast Cancer by Pegram, Mark D., Konecny, Gottfried E., O'Callaghan, Carminda, Beryt, Malgorzata, Pietras, Richard, Slamon, Dennis J.

“…Background: Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers…”
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Quantitative Association Between HER-2/neu and Steroid Hormone Receptors in Hormone Receptor-Positive Primary Breast Cancer by Konecny, Gottfried, Pauletti, Giovanni, Pegram, Mark, Untch, Michael, Dandekar, Sugandha, Aguilar, Zuleima, Wilson, Cindy, Rong, Hong-Mei, Bauerfeind, Ingo, Felber, Margret, Wang, He-Jing, Beryt, Malgorzata, Seshadri, Ram, Hepp, Herrmann, Slamon, Dennis J.

“…Background: HER-2/neu, which encodes a receptor tyrosine kinase, is amplified and overexpressed in 20%–25% of human breast cancers. Such tumors are often…”
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HER-2/neu overexpression and in vitro chemosensitivity to CMF and FEC in primary breast cancer by KONECNY, Gottfried, FRITZ, Manuel, UNTCH, Michael, LEBEAU, Annette, FELBER, Margrit, LUDE, Sandra, BERYT, Malgorzata, HEPP, Hermann, SLAMON, Dennis, PEGRAM, Mark

“…Available clinical and experimental data on the effect of HER-2/neu overexpression on chemosensitivity are controversial. It was the purpose of this in vitro…”
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315 POSTER A novel pan-HER ligand trap based on human EGFR (HER1) and HER3 inhibits tumor growth and metastasis in models of human cancer by Huang, Z, Shepard, H.M, Maneval, D, Jin, P, Beryt, M, Zhang, J, Brdlik, C, Cousens, L, Jorgensen, B, Bai, X

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Association between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients by KONECNY, Gottfried E, MENG, Y. Gloria, BERYT, Malgorzata, HEPP, Hermann, SLAMON, Dennis J, PEGRAM, Mark D, UNTCH, Michael, WANG, He-Jing, BAUERFEIND, Ingo, EPSTEIN, Melinda, STIEBER, Petra, VERNES, Jean-Michel, GUTIERREZ, Johnny, KYU HONG

“…Purpose: Activation or overexpression of HER-2/ neu is associated with up-regulation of vascular endothelial growth factor (VEGF) in human breast cancer cells…”
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Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers by PEGRAM, M, SHEREE HSU, LEWIS, G, PIETRAS, R, BERYT, M, SLIWKOWSKI, M, COOMBS, D, BALY, D, KABBINAVAR, F, SLAMON, D

“…Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To…”
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Hermodulins: bispecific ligand traps inhibit breast tumor growth and metastasis by Turin, L, Beryt, M, Zhang, J, Brdlik, C, Jin, P, Huang, J, Bai, X, Shepard, H

“…Abstract #4127 Signalling by the human EGF (HER) receptor family can induce tumorigenicity and metastasis of cancer cells. Activation of these receptors has…”
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The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells by PEGRAM, M. D, FINN, R. S, ARZOO, K, BERYT, M, PIETRAS, R. J, SLAMON, D. J

“…Recent studies indicate that oncogenes may be involved in determining the sensitivity of human cancers to chemotherapeutic agents. To define the effect of…”
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HER-2/neu and Urokinase-Type Plasminogen Activator and Its Inhibitor in Breast Cancer by KONECNY, Gottfried, UNTCH, Michael, SLAMON, Dennis, PEGRAM, Mark, ARBOLEDA, Jane, WILSON, Cindy, KAHLERT, Stephen, BOETTCHER, Berit, FELBER, Margrit, BERYT, Malgorzota, LUDE, Sandra, HEPP, Hermann

“…Purpose: Recent studies suggest that HER-2/neu specifically promotes the invasive capacity of tumor cells by up-regulating secretion of the proteolytic enzyme,…”
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Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples by KONECNY, Gottfried, UNTCH, Michael, SLAMON, Dennis, BERYT, Malgorzata, KAHLERT, Steffen, FELBER, Margret, LANGER, Elena, LUDE, Sandra, HEPP, Hermann, PEGRAM, Mark

“…The purpose of this study was to analyze the drug interactions of paclitaxel (PTX) with epirubicin (EPI), carboplatin (CBDCA), gemcitabine (GEM) and…”
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Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase by Lackey, David B., Groziak, Michael P., Sergeeva, Maria, Beryt, Malgorzata, Boyer, Christopher, Stroud, Robert M., Sayre, Peter, Park, John W., Johnston, Patrick, Slamon, Dennis, Shepard, H.Michael, Pegram, Mark

“…The in vivo administration of enzyme-inhibiting drugs for cancer and infectious disease often results in overexpression of the targeted enzyme. We have…”
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Inhibition of Cell Growth by NB1011 Requires High Thymidylate Synthase Levels and Correlates with p53, p21, Bax, and GADD45 Induction by Neuteboom, Saskia T C, Karjian, Patricia L, Boyer, Christopher R, Beryt, Malgorzhata, Pegram, Mark, Wahl, Geoffrey M, Shepard, H Michael

“…NB1011, a phosphoramidate derivative of ( E )-5-(2-bromovinyl)-2′-deoxyuridine, is a novel small molecule anticancer agent. NB1011 is selectively active…”
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