Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany

Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany

The neuropsychological performance of schoolchildren living in areas with present and past iodine deficiency in Tuscany was investigated. Children were submitted to: a) block design subtest of the Wechsler Intelligence Scale for Children-Revised (WISC-R) and a modified version of the WISC-R coding s...

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Bibliographic Details
Published in:Journal of endocrinological investigation Vol. 18; no. 1; pp. 57 - 62
Main Authors: AGHINI LOMBARDI, F, PINCHERA, A, VITTI, P, ANTONANGELI, L, RAGO, T, CHIOVATO, L, BARGAGNA, S, BERTUCELLI, B, FERRETTI, G, SBRANA, B, MARCHESCHI, M
Format: Journal Article
Language:English
Published: Milano Kurtis 1995
Subjects:
Biological and medical sciences
Child
Cognition
Endocrinopathies
Female
Goiter - epidemiology
Humans
Infant, Newborn
Iodine - administration & dosage
Iodine - deficiency
Iodine - urine
Italy
Male
Medical sciences
Nervous System Diseases - epidemiology
Nervous System Diseases - etiology
Neuropsychological Tests
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pregnancy
Prenatal Exposure Delayed Effects
Reaction Time
Thyroid. Thyroid axis (diseases)
Italy
Europe
Tuscany
Endocrinopathy
Human
Psychomotor development
Intellectual development
Pathogenesis
Deficiency
Thyroid diseases
Nutrition disorder
Hypothyroidism
Retrospective
Cretinism
Newborn
Fetus
Nutritional deficiency
Iodine
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Summary:The neuropsychological performance of schoolchildren living in areas with present and past iodine deficiency in Tuscany was investigated. Children were submitted to: a) block design subtest of the Wechsler Intelligence Scale for Children-Revised (WISC-R) and a modified version of the WISC-R coding subtest which evaluate the general neuropsychological and cognitive performance, independently from familial cultural background; b) simple reaction time (RT) session which evaluates the efficiency of the whole information processing and nervous transmission mechanisms. Neuropsychological performance was tested in 107 children living in Borgo a Mozzano, an area of mild iodine deficiency (IDA) with a median urinary iodine excretion (UIE) of 64 micrograms/L (mean +/- SD: 80.1 +/- 57). One hundred and six sex and age-matched children living in Marina di Pisa, an iodine sufficient coastal village of Tuscany (ISA) with a median UIE of 142 micrograms/L (mean +/- SD: 173 +/- 95) were used as controls. Tests for neuropsychological performance were performed in 57 children living in the village of Vagli, an area with past iodine deficiency (PIDA): 30 children born before iodine prophylaxis (Group 1), when the median UIE was 32 micrograms/L (mean +/- SD: 47 +/- 22), 27 children born after the institution of iodine prophylaxis (Group 2), when the median UIE was 109 micrograms/L (mean +/- SD: 130 +/- 73). Sex and age-matched ISA-children were used as controls for each group. RTs were significantly delayed (p < 0.05) in IDA than in ISA children, while block design and coding subtests showed no significant difference.
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ISSN:0391-4097
1720-8386
DOI:10.1007/BF03349700