Search Results - "BERTRAND, Pascale"

Is non-homologous end-joining really an inherently error-prone process? by Bétermier, Mireille, Bertrand, Pascale, Lopez, Bernard S

“…DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair…”
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Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells by Rass, Emilie, Gautier, Jean, Bertrand, Pascale, Grabarz, Anastazja, Plo, Isabelle, Lopez, Bernard S

“…The MRN complex is known to play a role in the cellular response to DNA double-strand breaks in higher eukaryotes, particularly in damage signaling and…”
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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication by Leriche, Melissa, Bonnet, Clara, Jana, Jagannath, Chhetri, Gita, Mennour, Sabrina, Martineau, Sylvain, Pennaneach, Vincent, Busso, Didier, Veaute, Xavier, Bertrand, Pascale, Lambert, Sarah, Somyajit, Kumar, Uguen, Patricia, Vagner, Stéphan

“…RNA-binding proteins (RBPs) are found at replication forks, but their direct interaction with DNA-embedded RNA species remains unexplored. Here, we report that…”
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Is homologous recombination really an error-free process? by Guirouilh-Barbat, Josée, Lambert, Sarah, Bertrand, Pascale, Lopez, Bernard S

“…Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal role in the equilibrium between genetic stability and diversity. HR…”
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Defects in XRCC4 and KU80 Differentially Affect the Joining of Distal Nonhomologous Ends by Guirouilh-Barbat, Josée, Rass, Emilie, Plo, Isabelle, Bertrand, Pascale, Lopez, Bernard S.

“…XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous…”
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Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells by Guirouilh-Barbat, Josée, Huck, Sylvie, Bertrand, Pascale, Pirzio, Livia, Desmaze, Chantal, Sabatier, Laure, Lopez, Bernard S.

“…Using a substrate measuring deletion or inversion of an I-SceI-excised fragment and both accurate and inaccurate rejoining, we determined the impact of…”
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A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining by Grabarz, Anastazja, Guirouilh-Barbat, Josée, Barascu, Aurélia, Pennarun, Gaëlle, Genet, Diane, Rass, Emilie, Germann, Susanne M., Bertrand, Pascale, Hickson, Ian D., Lopez, Bernard S.

“…The choice of the appropriate double-strand break (DSB) repair pathway is essential for the maintenance of genomic stability. Here, we show that the Bloom…”
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MutS Homologue 2 and the Long-term Benefit of Adjuvant Chemotherapy in Lung Cancer by KAMAL, Nermine S, SORIA, Jean-Charles, LE CHEVALIER, Thierry, FILIPITS, Martin, FOURET, Pierre, MENDIBOURE, Jean, PLANCHARD, David, OLAUSSEN, Ken A, ROUSSEAU, Vanessa, POPPER, Helmut, PIRKER, Robert, BERTRAND, Pascale, DUNANT, Ariane

“…Purpose: We sought to determine the long-term (median follow-up, 7.5 years) predictive power of human MutS homologue 2 (MSH2) immunohistochemical expression in…”
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Bcl-2 Inhibits Nuclear Homologous Recombination by Localizing BRCA1 to the Endomembranes by LAULIER, Corentin, BARASCU, Aurélia, GUIROUILH-BARBAT, Josee, PENNARUN, Gaëlle, LE CHALONY, Catherine, CHEVALIER, François, PALIERNE, Gaëlle, BERTRAND, Pascale, MARC VERBAVATZ, Jean, LOPEZ, Bernard S

“…Genetic stability requires coordination of a network of pathways including DNA repair/recombination and apoptosis. In addition to its canonical anti-apoptotic…”
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Oxydative stress alters nuclear shape through lamins dysregulation: A route to senescence by Barascu, Aurélia, Le Chalony, Catherine, Pennarun, Gaëlle, Genet, Diane, Zaarour, Nancy, Bertrand, Pascale

“…Progeroid phenotypes are mainly encountered in 2 types of syndromes: in laminopathies, which are characterized by nuclear shape abnormalities due to lamin A…”
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Jaagsiekte Sheep Retrovirus Utilizes a pH-Dependent Endocytosis Pathway for Entry by BERTRAND, Pascale, COTE, Marceline, ZHENG, Yi-Min, ALBRITTON, Lorraine M, LIU, Shan-Lu

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification and Characterization of Saccharomyces cerevisiae EXO1, a Gene Encoding an Exonuclease that Interacts with MSH2 by Tishkoff, Daniel X., Boerger, Adrienne L., Bertrand, Pascale, Filosi, Nicole, Gaida, Gretchen M., Kane, Michael F., Kolodner, Richard D.

“…A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of…”
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Physical interaction between components of DNA mismatch repair and nucleotide excision repair by Bertrand, P. (Dana-Farber Cancer Institute, Boston, MA.), Tishkoff, D.X, Filosi, N, Dasgupta, R, Kolodner, R.D

“…Nucleotide excision repair (NER) and DNA mismatch repair are required for some common processes although the biochemical basis for this requirement is unknown…”
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53BP1: Keeping It under Control, Even at a Distance from DNA Damage by Rass, Emilie, Willaume, Simon, Bertrand, Pascale

“…Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents or during physiological processes, such as during V(D)J…”
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Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein by BERTRAND, P, ROUILLARD, D, BOULET, A, LEVALOIS, C, SOUSSI, T, LOPEZ, B. S

“…Homologous recombination plays an essential role in processes involved in genome stability/instability, such as molecular evolution, gene diversification,…”
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Human POMP75 is identified as the pro-oncoprotein TLS/FUS : both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation by BERTRAND, P, AKHMEDOV, A. T, DELACOTE, F, DURRBACH, A, LOPEZ, B. S

“…We have previously developed an assay to measure DNA homologous pairing activities in crude extracts: The POM blot. In mammalian nuclear extracts, we detected…”
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Anin vitro enzymatic assay coupled to proteomics analysis reveals a new DNA processing activity for Ewing sarcoma and TAF(II)68 proteins by Guipaud, Olivier, Guillonneau, François, Labas, Valérie, Praseuth, Danièle, Rossier, Jean, Lopez, Bernard, Bertrand, Pascale

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Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation by Barascu, Aurelia, Le Chalony, Catherine, Pennarun, Gaëlle, Genet, Diane, Imam, Naima, Lopez, Bernard, Bertrand, Pascale

“…We report crosstalk between three senescence‐inducing conditions, DNA damage response (DDR) defects, oxidative stress (OS) and nuclear shape alterations. The…”
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Close Ties between the Nuclear Envelope and Mammalian Telomeres: Give Me Shelter by Pennarun, Gaëlle, Picotto, Julien, Bertrand, Pascale

“…The nuclear envelope (NE) in eukaryotic cells is essential to provide a protective compartment for the genome. Beside its role in connecting the nucleus with…”
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Down‐regulation of BRCA1 expression by miR‐146a and miR‐146b‐5p in triple negative sporadic breast cancers by Garcia, Amandine I., Buisson, Monique, Bertrand, Pascale, Rimokh, Ruth, Rouleau, Etienne, Lopez, Bernard S., Lidereau, Rosette, Mikaélian, Ivan, Mazoyer, Sylvie

“…Germ‐line mutations in the BRCA1 gene strongly predispose women to breast cancer (lifetime risk up to 80%). Furthermore, the BRCA1 protein is absent or present…”
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