Search Results - "BERTELSEN, L"

When size matters: transient receptor potential vanilloid 4 channel as a volume‐sensor rather than an osmo‐sensor by Toft‐Bertelsen, Trine L., Križaj, David, MacAulay, Nanna

“…Key points Mammalian cells are frequently exposed to stressors causing volume changes. The transient receptor potential vanilloid 4 (TRPV4) channel translates…”
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TRPing on Cell Swelling - TRPV4 Senses It by Toft-Bertelsen, Trine L, MacAulay, Nanna

“…The transient receptor potential vanilloid 4 channel (TRPV4) is a non-selective cation channel that is widely expressed and activated by a range of stimuli…”
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TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel by Toft-Bertelsen, Trine L, MacAulay, Nanna

“…The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed,…”
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Toward New AQP4 Inhibitors: ORI-TRN-002 by Thormann, Michael, Traube, Nadine, Yehia, Nasser, Koestler, Roland, Galabova, Gergana, MacAulay, Nanna, Toft-Bertelsen, Trine L

“…Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the…”
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Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells by Hoda, M. R., Keely, S. J., Bertelsen, L. S., Junger, W. G., Dharmasena, D., Barrett, K. E.

“…Background: Obesity is associated with increased levels of leptin. The mitogenic actions of leptin have been identified in various cell types. Because obesity…”
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Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters by Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, Tenna, Olsen, Markus Harboe, Norager, Nicolas H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine L., Ye, Fenghui, Juhler, Marianne, Keep, Richard F., MacAulay, Nanna

“…Introduction Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and subarachnoid…”
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Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1 by Toft-Bertelsen, Trine L, Barbuskaite, Dagne, Heerfordt, Eva Kjer, Lolansen, Sara Diana, Andreassen, Søren Norge, Rostgaard, Nina, Olsen, Markus Harboe, Norager, Nicolas H, Capion, Tenna, Rath, Martin Fredensborg, Juhler, Marianne, MacAulay, Nanna

“…A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as…”
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Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23 by Weber, Jens P, Toft-Bertelsen, Trine L, Mohrmann, Ralf, Delgado-Martinez, Ignacio, Sørensen, Jakob B

“…Synchronization of neurotransmitter release with the presynaptic action potential is essential for maintaining fidelity of information transfer in the central…”
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Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus by Andreassen, Søren N, Toft-Bertelsen, Trine L, Wardman, Jonathan H, Villadsen, René, MacAulay, Nanna

“…Dysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial pressure. Surgical…”
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Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus by Barbuskaite, Dagne, Oernbo, Eva K, Wardman, Jonathan H, Toft-Bertelsen, Trine L, Conti, Eller, Andreassen, Saren N, Gerkau, Niklas J, Rose, Christine R, MacAulay, Nanna

“…Background Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely…”
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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure by Oernbo, Eva K, Steffensen, Annette B, Razzaghi Khamesi, Pooya, Toft-Bertelsen, Trine L, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, Niklas J, Tritsaris, Katerina, Simonsen, Anja H, Lolansen, Sara D, Andreassen, Saren N, Hasselbalch, Steen G, Zeuthen, Thomas, Rose, Christine R, Kurtcuoglu, Vartan, MacAulay, Nanna

“…Background Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical…”
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The SNARE protein vti1a functions in dense-core vesicle biogenesis by Walter, Alexander M, Kurps, Julia, de Wit, Heidi, Schöning, Susanne, Toft-Bertelsen, Trine L, Lauks, Juliane, Ziomkiewicz, Iwona, Weiss, Annita N, Schulz, Alexander, Fischer von Mollard, Gabriele, Verhage, Matthijs, Sørensen, Jakob B

“…The SNARE protein vti1a is proposed to drive fusion of intracellular organelles, but recent data also implicated vti1a in exocytosis. Here we show that vti1a…”
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CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension by Wardman, Jonathan H, Andreassen, Søren Norge, Toft-Bertelsen, Trine L, Jensen, Mette Nyholm, Wilhjelm, Jens E, Styrishave, Bjarne, Hamann, Steffen, Heegaard, Steffen, Sinclair, Alexandra J, MacAulay, Nanna

“…Idiopathic intracranial hypertension (IIH) is a syndrome exhibiting elevated intracranial pressure (ICP), visual disturbances, and severe headache. IIH…”
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Surface states and related quantum interference in ab initio electron transport by Li, Dongzhe, Bertelsen, Jonas L., Papior, Nick, Smogunov, Alexander, Brandbyge, Mads

“…Shockley surface states (SS) have attracted much attention due to their role in various physical phenomena occurring at surfaces. It is also clear from…”
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Comparison of Patients Undergoing Primary Shoulder Arthroplasty Before and After the Age of Fifty by Saltzman, Matthew D, Mercer, Deana M, Warme, Winston J, Bertelsen, Alexander L, Matsen, Frederick A

“…BACKGROUND:The reported outcomes of shoulder arthroplasty in patients under the age of fifty years are worse than those in patients over fifty. While there are…”
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Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus by Toft-Bertelsen, Trine L, Andreassen, Søren Norge, Rostgaard, Nina, Olsen, Markus Harboe, Norager, Nicolas H, Capion, Tenna, Juhler, Marianne, MacAulay, Nanna

“…Patients with subarachnoid hemorrhage (SAH) may develop posthemorrhagic hydrocephalus (PHH), which is treated with surgical cerebrospinal fluid (CSF)…”
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Glenohumeral chondrolysis: A systematic review of 100 cases from the English language literature by Scheffel, Peter T., MD, Clinton, Jeremiah, MD, Lynch, Joseph R., MD, Warme, Winston J., MD, Bertelsen, Alexander L., PAC, Matsen, Frederick A., MD

“…Hypothesis Chondrolysis can be a devastating complication of shoulder arthroscopy. We undertook a review of the 100 cases reported in the English language to…”
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Reply to: How Many SARS-CoV-2 “Viroporins” Are Really Ion Channels? by Toft-Bertelsen, Trine L., Jeppesen, Mads Gravers, Landbrug, Asante, Mujezinovic, Amer, Bentzen, Bo Hjorth, Kledal, Thomas Nitschke, Rosenkilde, Mette Marie

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Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis by MacAulay, Nanna, Toft-Bertelsen, Trine L.

“…•The choroid plexus serves to secrete the cerebrospinal fluid (CSF).•CSF does not appear to be produced by conventional osmosis.•CSF secretion occurs with Na+…”
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Publisher Correction: Reply to: How many SARS-CoV-2 “viroporins” are really ion channels? by Toft-Bertelsen, Trine L., Jeppesen, Mads Gravers, Landbrug, Asante, Mujezinovic, Amer, Bentzen, Bo Hjorth, Kledal, Thomas Nitschke, Rosenkilde, Mette Marie

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