Search Results - "BERNS, K. I"

Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors by SONG, S, EMBURY, J, LAIPIS, P. J, BERNS, K. I, CRAWFORD, J. M, FLOTTE, T. R

“…Previous work from our group showed that recombinant adeno-associated virus (rAAV) vectors mediated long-term secretion of therapeutic serum levels of human…”
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Characterization of a bipartite recombinant adeno-associated viral vector for site-specific integration by Zhang, C, Cortez, N G, Berns, K I

“…Adeno-associated virus type 2 (AAV2) is the only virus known to integrate into a specific locus in the human genome. The locus, AAVS1, is on the q arm of…”
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Parvovirus replication by BERNS, K. I

“…The members of the family Parvoviridae are among the smallest of the DNA viruses, with a linear single-stranded genome of about 5 kilobases. Currently the…”
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Biology of adeno-associated virus by Berns, K I, Giraud, C

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Site-Specific Integration by Adeno-Associated Virus by Linden, R. Michael, Ward, Peter, Giraud, Catherine, Winocour, Ernest, Berns, Kenneth I.

“…Adeno-associated virus (AAV) has attracted considerable interest as a potential vector for gene delivery. Wild-type virus is notable for the lack of…”
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The Recombination Signals for Adeno-Associated Virus Site-Specific Integration by Linden, R. Michael, Winocour, Ernest, Berns, Kenneth I.

“…The adeno-associated virus (AAV) genome integrates site specifically into a defined region of human chromosome 19 (termed AAVS1). Using a functional assay for…”
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Effect of DNA-Dependent Protein Kinase on the Molecular Fate of the rAAV2 Genome in Skeletal Muscle by Song, Sihong, Laipis, Philip J., Berns, Kenneth I., Flotte, Terence R.

“…We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecular fate of the recombinant adeno-associated virus (rAAV) genome in skeletal…”
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Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein by BEATON, A, PALUMBO, P, BERNS, K. I

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Recombinant angiostatin prevents retinal neovascularization in a murine proliferative retinopathy model by MENESES, P. I, HAJJAR, K. A, BERNS, K. I, DUVOISIN, R. M

“…Retinal neovascularization is central to the pathogenesis of proliferative diabetic retinopathy, the leading cause of blindness among the middle-aged…”
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Site-Specific Integration by Adeno-Associated Virus is Directed by a Cellular DNA Sequence by Giraud, Catherine, Winocour, Ernest, Berns, Kenneth I.

“…Different regions of an 8.2-kb cloned DNA segment containing the target for adeno-associated virus (AAV) integration in human chromosome 19q13.3-qter (AAVS1…”
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Site-Specific Integration by Adeno-Associated Virus by Kotin, Robert M., Siniscalco, Marcello, Samulski, R. Jude, Zhu, Xiaodong, Hunter, Lynne, Laughlin, Catherine A., McLaughlin, Susan, Muzyczka, Nicholas, Rocchi, Marino, Berns, Kenneth I.

“…Cellular sequences flanking integrated copies of the adeno-associated virus (AAV) genome were isolated from a latently infected clonal human cell line and used…”
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Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome by Giraud, C, Winocour, E, Berns, K I

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In vitro Replication of Adeno-Associated Virus DNA by Hong, G., Ward, P., Berns, K. I.

“…An in vitro assay for adeno-associated virus (AAV) DNA replication has been developed. The substrate is a plasmid containing the duplex form of AAV DNA in…”
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Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein by WARD, P, URECLAY, E, KOTIN, R, SAFER, B, BERNS, K. I

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Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter by Kotin, R M, Menninger, J C, Ward, D C, Berns, K I

“…A human parvovirus, adeno-associated virus (AAV), is unique among eukaryotic DNA viruses in its ability to integrate site specifically into a defined region of…”
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Nucleotide sequence and organization of the adeno-associated virus 2 genome by Srivastava, A, Lusby, E W, Berns, K I

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Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants by HERMONAT, P. L, LABOW, M. A, WRIGHT, R, BERNS, K. I, MUZYCZKA, N

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Positive and negative autoregulation of the adeno-associated virus type 2 genome by LABOW, M. A, HERMONAT, P. L, BERNS, K. I

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Intermediates of adeno-associated virus DNA replication in vitro by HONG, G, WARD, P, BERNS, K. I

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In vitro rescue of an integrated hybrid adeno-associated virus/simian virus 40 genome by Ward, P, Berns, K I

“…In an in vitro simian virus 40 (SV40) DNA replication assay, we have observed excision of a hybrid adeno-associated virus (AAV)/SV40 insert from a plasmid…”
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