Search Results - "BERKOW, R"

Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor by Berkow, RL, Wang, D, Larrick, JW, Dodson, RW, Howard, TH

“…Tumor necrosis factor (TNF) is a 17,000-Da protein which is produced by mononuclear cells upon exposure to endotoxin. Increases in adherence, phagocytosis,…”
Get full text

Bryostatin, an Activator of the Calcium Phospholipid-Dependent Protein Kinase, Blocks Phorbol Ester-Induced Differentiation of Human Promyelocytic Leukemia Cells HL-60 by Kraft, Andrew S., Smith, Jeffrey B., Berkow, Roger L.

“…Phorbol esters bind to and activate a calcium phospholipid-dependent protein kinase (C kinase). Some researchers believe that activation of C kinase is…”
Get full text

Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability by Royall, J A, Berkow, R L, Beckman, J S, Cunningham, M K, Matalon, S, Freeman, B A

“…Endotoxic shock is associated with acute vascular endothelial injury resulting in edema. Tumor necrosis factor (TNF) and interleukin 1 (IL-1) are cytokines…”
Get full text

A Phase I Trial of Bryostatin-1 in Children with Refractory Solid Tumors: A Pediatric Oncology Group Study by WEITMAN, S, LANGEVIN, A.-M, BERKOW, R. L, THOMAS, P. J, HURWITZ, C. A, KRAFT, A. S, DUBOWY, R. L, SMITH, D. L, BERNSTEIN, M

“…Bryostatin-1, a macrocyclic lactone, appears to elicit a wide range of biological responses including modulation of protein kinase C (PKC). PKC, one of the…”
Get full text

Tyrosine-Specific Protein Phosphorylation During Activation of Human Neutrophils by Berkow, Roger L., Dodson, Robert W.

“…The activation of human neutrophils by a variety of receptor-dependent and receptor-independent agonists induces the phosphorylation of a large number of…”
Get full text

Prevention of tumor lysis syndrome using continuous veno-venous hemofiltration by SACCENTE, S. L, KOHAUT, E. C, BERKOW, R. L

“…Tumor lysis syndrome (TLS) and renal failure remain significant causes of morbidity and mortality in children with newly diagnosed Burkitt's lymphoma and high…”
Get full text

Phase II investigational window using carboplatin, iproplatin, ifosfamide, and epirubicin in children with untreated disseminated neuroblastoma: a Pediatric Oncology Group study by Castleberry, R P, Cantor, A B, Green, A A, Joshi, V, Berkow, R L, Buchanan, G R, Leventhal, B, Mahoney, D H, Smith, E I, Hayes, F A

“…Children less than 1 year of age with metastatic neuroblastoma NB are at high risk of death. The need to identify new and effective chemotherapy agents is…”
Get more information

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor by Berkow, R L, Kraft, A S

“…Bryostatin, is an antineoplastic agent with activity in both solid and liquid tumors. When added to tissue culture cells this agent shares a number of…”
Get more information

Lipopolysaccharide modulates chemotactic peptide-induced actin polymerization in neutrophils by Howard, T H, Wang, D, Berkow, R L

“…To study the effect of endotoxin (LPS) on the basal and chemotactic peptide, formyl-methionyl-leucyl-phenylalanine (fMLP)-induced alterations in neutrophil…”
Get more information

Granulocyte-Macrophage Colony-Stimulating Factor Induces a Staurosporine Inhibitable Tyrosine Phosphorylation of Unique Neutrophil Proteins by Berkow, Roger L.

“…Human neutrophils treated with chemotactic peptides or phorbol esters demonstrate tyrosine phosphorylation of a subset of proteins. Granulocyte-macrophage…”
Get full text

Biochemical mechanisms involved in the priming of neutrophils by tumor necrosis factor by Berkow, R L, Dodson, M R

“…Preincubation of human neutrophils with recombinant tumor necrosis factor alpha has previously been shown by us to enhance superoxide production of neutrophils…”
Get more information

Chronic granulomatous disease in two children with recurrent infections: Family studies using dihydrorhodamine-based flow cytometry by Atkinson, T.Prescott, Bonitatibus, Gina M., Berkow, Roger L.

“…We employed a recently published technique, flow cytometry using the cell permeant dye dihydrorhodamine, to analyze families of two patients with X-linked…”
Get full text

The effect of a protein kinase C inhibitor, H-7, on human neutrophil oxidative burst and degranulation by Berkow, R L, Dodson, R W, Kraft, A S

“…The role of C-kinase in the activation of human polymorphonuclear leukocytes has been examined using H-7, a recently described C-kinase inhibitor. We found…”
Get more information

Chronic granulomatous disease due to a defect in the cytosolic factor required for nicotinamide adenine dinucleotide phosphate oxidase activation by CURNUTTE, J. T, BERKOW, R. L, ROBERTS, R. L, SHURIN, S. B, SCOTT, P. J

“…The superoxide-generating enzyme of human neutrophils, NADPH oxidase, is present in a dormant state in unstimulated neutrophils. It can be converted to an…”
Get full text

Tyrosine Kinase and Phosphotyrosine Phosphatase Activity in Human Promyelocytic Leukemia Cells and Human Polymorphonuclear Leukocytes by Kraft, Andrew S., Berkow, Roger L.

“…Although an increase in protein phosphorylation on tyrosine was first noted as a result of cell transformation or the application of growth factors to cells,…”
Get full text

Alterations in tyrosine protein kinase activities upon activation of human neutrophils by Berkow, R L, Dodson, R W

“…Human neutrophils are phagocytic cells that can be activated by a variety of agonists to undergo a group of physiologic responses. This "stimulus-response"…”
Get more information

Purification and Functional Evaluation of Mature Neutrophils From Human Bone Marrow by Berkow, Roger L., Dodson, Robert W.

“…Human myeloid maturation proceeds within the bone marrow and results in a mature neutrophil that is released into the peripheral circulation. Previous reports…”
Get full text

Regulation of neutrophil respiratory burst by protein phosphatases by Berkow, R L, Dodson, R W

“…Activation of human neutrophils involves a series of biochemical events which have been linked to the phosphorylation of specific proteins. Okadaic acid is an…”
Get more information

In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity by BERKOW, R. L, SCHLABACH, L, DODSON, R, BENJAMIN, W. H, PETTIT, G. R, RUSTAGI, P, KRAFT, A. S

“…Bryostatin 1 is a naturally occurring macrocyclic lactone which when applied to cells in culture activates protein kinase C (PKC). In vivo bryostatin 1…”
Get full text

Psychological Outcomes in Long-Term Survivors of Childhood Leukemia, Hodgkin's Disease, and Non-Hodgkin's Lymphoma: A Report From the Childhood Cancer Survivor Study by Zebrack, Brad J, Zeltzer, Lonnie K, Whitton, John, Mertens, Ann C, Odom, Lorrie, Berkow, Roger, Robison, Leslie L

“…To evaluate and compare psychological outcomes in long-term survivors of pediatric leukemia, Hodgkin's disease, and non-Hodgkin's lymphoma and sibling…”
Get full text