Search Results - "BERK, BARKIN"

Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl‐1,2,4‐triazines by Sahin, Zafer, Biltekin, Sevde Nur, Ozansoy, Mehmet, Hemiş, Bervis, Ozansoy, Muzaffer Beyza, Yurttaş, Leyla, Berk, Barkin, Demirayak, Şeref

“…Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3‐triazine,…”
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Pyridine‐substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation by Ertas, Merve, Sahin, Zafer, Berk, Barkin, Yurttas, Leyla, Biltekin, Sevde N., Demirayak, Seref

“…Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase…”
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Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors by Sahin, Zafer, Biltekin, Sevde Nur, Bülbül, Emre Fatih, Yurttas, Leyla, Berk, Barkin, Demirayak, Şeref

“…Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase…”
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Novel thiazole‐piperazine derivatives as potential cholinesterase inhibitors by Demirayak, Şeref, Şahin, Zafer, Ertaş, Merve, Bülbül, Emre Fatih, Bender, Ceysu, Biltekin, Sevde Nur, Berk, Barkin, Sağlık, Begüm Nurpelin, Levent, Serkan, Yurttaş, Leyla

“…Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system…”
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Potent ribonucleotide reductase inhibitors: Thiazole‐containing thiosemicarbazone derivatives by Ertas, Merve, Sahin, Zafer, Bulbul, Emre F., Bender, Ceysu, Biltekin, Sevde N., Berk, Barkin, Yurttas, Leyla, Nalbur, Aysu M., Celik, Hayati, Demirayak, Şeref

“…The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal…”
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Thiazole‐substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors by Sahin, Zafer, Ertas, Merve, Bender, Ceysu, Bülbül, Emre F., Berk, Barkin, Biltekin, Sevde N., Yurttaş, Leyla, Demirayak, Şeref

“…Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE)…”
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Synthesis and antimycobacterial activity of some phthalimide derivatives by Akgün, Hülya, Karamelekoğlu, İrem, Berk, Barkın, Kurnaz, Işıl, Sarıbıyık, Gizem, Öktem, Sinem, Kocagöz, Tanıl

“…A series of fluorinated phthalimide derivatives were evaluated against Mycobacterium tuberculosis H37Ra (ATCC 25177), and the compounds 2d, 2f, and 2h showed…”
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The Importance of Computerized Drug Interaction Checker Programs Used in Community Pharmacies to Avoid Potential Drug Interactions: A Preliminary Study with Clarithromycin by Şimşek, Abdullah, Taner, Neda, Macit, Çağlar, Berk, Barkın, Mercanoğlu, Güldem

“…Introduction:Drug-drug interactions (DDI) due to multiple drug use are the most important cause of adverse drug reactions. DDIs are among medication errors…”
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Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors by Sahin, Zafer, Biltekin, Sevde Nur, Yurttaş, Leyla, Berk, Barkin, Küçükkılınç, Tuba Tüylü, Demirayak, Şeref

“…•Microwave synthesis step for benzofurane ring closure.•Close and remarkable one digit micromolar acetylcholinesterase inhibitor activity compared to…”
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Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition by Sahin, Zafer, Biltekin, Sevde Nur, Yurttas, Leyla, Berk, Barkin, Özhan, Yağmur, Sipahi, Hande, Gao, Zhan-Guo, Jacobson, Kenneth A., Demirayak, Şeref

“…Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated…”
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Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives by Coşkun, Göknil Pelin, Sahin, Zafer, Erdoğan, Ömer, Çevik, Özge, Biltekin, Sevde Nur, Yurttas, Leyla, Berk, Barkin, Ülgen, Mert, Demirayak, Şeref

“…•24 novel thiazole derivatives were synthesized.•Chondrosarcoma inhibitors are discovered.•Apoptotic pathways are monitorized.•Tyrosine kinases could be the…”
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Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation by Sahin, Zafer, Özhan, Yağmur, Sipahi, Hande, Biltekin, Sevde Nur, Yurttaş, Leyla, Berk, Barkin, Demirayak, Şeref

“…Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties…”
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In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor by Vilar, Santiago, Karpiak, Joel, Berk, Barkin, Costanzi, Stefano

“…Activation of G protein-coupled receptors (GPCRs) is a complex phenomenon. Here, we applied Induced Fit Docking (IFD) in tandem with linear discriminant…”
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Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles by Şahin, Zafer, Koçoğlu Kalkan, Melike, Berk, Barkın, Yurttaş, Leyla, Bender, Ceysu, Biltekin Kaleli, Sevde Nur, Demirayak, Şeref

“…Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements…”
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Docking-based virtual screening for ligands of G protein-coupled receptors: Not only crystal structures but also in silico models by Vilar, Santiago, Ferino, Giulio, Phatak, Sharangdhar S., Berk, Barkin, Cavasotto, Claudio N., Costanzi, Stefano

“…[Display omitted] ▶ Explored the applicability of GPCR crystal structures to docking-based virtual screenings. ▶ Improved the performance of the screening…”
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The Importance of Computerized Drug Interaction Checker Programs Used in Community Pharmacies to Avoid Potential Drug Interactions: A Preliminary Study with Clarithromycin/ Potansiyel Ilac Etkilesimlerinin Onlenmesinde Serbest Eczanelerde Kullanilan Bilgisayarli Ilac Etkilesimi Kontrol Programlarinin Onemi: Klaritromisin ile Yapilan Bir On Calisma by Simsek, Abdullah, Taner, Neda, Macit, Caglar, Berk, Barkin, Mercanoglu, Guldem

“…Introduction: Drug-drug interactions (DDI) due to multiple drug use are the most important cause of adverse drug reactions. DDIs are among medication errors…”
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The Importance of Computerized Drug Interaction Checker Programs to Avoid Potential Drug-Drug Interactions used in Community Pharmacies: A Preliminary Study with Clarithromycin by Simsek, Abdullah, Macit, Caglar, Taner, Neda, Berk, Barkin, Mercanoglu, Guldem

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Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y6 Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications by Maruoka, Hiroshi, Barrett, Matthew O, Ko, Hyojin, Tosh, Dilip K, Melman, Artem, Burianek, Lauren E, Balasubramanian, Ramachandran, Berk, Barkin, Costanzi, Stefano, Harden, T. Kendall, Jacobson, Kenneth A

“…The P2Y6 receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC50 = 0.30 μM). We compared and combined modifications to enhance…”
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Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications by Maruoka, Hiroshi, Barrett, Matthew O, Ko, Hyojin, Tosh, Dilip K, Melman, Artem, Burianek, Lauren E, Balasubramanian, Ramachandran, Berk, Barkin, Costanzi, Stefano, Harden, T Kendall, Jacobson, Kenneth A

“…The P2Y(6) receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC(50) = 0.30 microM). We compared and combined modifications to…”
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In silico analysis of the binding of agonists and blockers to the I22-adrenergic receptor by Vilar, Santiago, Karpiak, Joel, Berk, Barkin, Costanzi, Stefano

“…Activation of G protein-coupled receptors (GPCRs) is a complex phenomenon. Here, we applied Induced Fit Docking (IFD) in tandem with linear discriminant…”
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