Search Results - "BERGMAN, BRYAN"

Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity by Bergman, Bryan C, Goodpaster, Bret H

“…Accumulation of lipid in skeletal muscle is thought to be related to the development of insulin resistance and type 2 diabetes. Initial work in this area…”
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Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance by Kahn, Darcy E, Bergman, Bryan C

“…Alterations in adipose tissue composition and function are associated with obesity and contribute to the development of type 2 diabetes. While the significance…”
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The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health? by Sparks, Lauren Marie, Goodpaster, Bret H, Bergman, Bryan C

“…Adipose tissues are not homogeneous and show site-specific properties. An elusive and understudied adipose tissue depot, most likely due to its limited…”
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Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep by Depner, Christopher M., Melanson, Edward L., Eckel, Robert H., Snell-Bergeon, Janet K., Perreault, Leigh, Bergman, Bryan C., Higgins, Janine A., Guerin, Molly K., Stothard, Ellen R., Morton, Sarah J., Wright, Kenneth P.

“…People commonly increase sleep duration on the weekend to recover from sleep loss incurred during the workweek. Whether ad libitum weekend recovery sleep…”
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Intermuscular adipose tissue in metabolic disease by Goodpaster, Bret H., Bergman, Bryan C., Brennan, Andrea M., Sparks, Lauren M.

“…Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as a ‘fatty replacement’ or ‘muscle fat infiltration’ that was…”
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Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging by Correa-de-Araujo, Rosaly, Addison, Odessa, Miljkovic, Iva, Goodpaster, Bret H, Bergman, Bryan C, Clark, Richard V, Elena, Joanne W, Esser, Karyn A, Ferrucci, Luigi, Harris-Love, Michael O, Kritchevsky, Steve B, Lorbergs, Amanda, Shepherd, John A, Shulman, Gerald I, Rosen, Clifford J

“…Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with…”
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1638-P: Oxidized Lipids Cause Ceramide Accumulation and Insulin Resistance in Skeletal Muscle by ZEMSKI BERRY, KARIN, BERGMAN, BRYAN C.

“…Accumulation of muscle lipids promotes insulin resistance and type 2 diabetes (T2D). Ceramides are important muscle lipids that decrease insulin sensitivity…”
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Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans by Sachs, Stephan, Zarini, Simona, Kahn, Darcy E, Harrison, Kathleen A, Perreault, Leigh, Phang, Tzu, Newsom, Sean A, Strauss, Allison, Kerege, Anna, Schoen, Jonathan A, Bessesen, Daniel H, Schwarzmayr, Thomas, Graf, Elisabeth, Lutter, Dominik, Krumsiek, Jan, Hofmann, Susanna M, Bergman, Bryan C

“…Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is…”
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Out of stock: A brief clinical reference for rough equivalency of glucagon‐like peptide‐1 (GLP‐1) ± glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes by Perreault, Leigh, Bergman, Bryan C.

“…Highlights Despite the common practice of switching patients from one medicine to another—to improve efficacy, safety, or tolerability—guidance on how to do so…”
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Dietary Fatty Acids Differentially Associate with Fasting Versus 2-Hour Glucose Homeostasis: Implications for The Management of Subtypes of Prediabetes by Guess, Nicola, Perreault, Leigh, Kerege, Anna, Strauss, Allison, Bergman, Bryan C

“…Over-nutrition has fuelled the global epidemic of type 2 diabetes, but the role of individual macronutrients to the diabetogenic process is not well…”
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Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans by Bergman, Bryan C., Brozinick, Joseph T., Strauss, Allison, Bacon, Samantha, Kerege, Anna, Bui, Hai Hoang, Sanders, Phil, Siddall, Parker, Wei, Tao, Thomas, Melissa K., Kuo, Ming Shang, Perreault, Leigh

“…Aims/hypotheses Ceramides and other sphingolipids comprise a family of lipid molecules that accumulate in skeletal muscle and promote insulin resistance…”
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Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle by Zemski Berry, Karin A, Garfield, Amanda, Jambal, Purevsuren, Zarini, Simona, Perreault, Leigh, Bergman, Bryan C

“…Intracellular ceramide accumulation in specific cellular compartments is a potential mechanism explaining muscle insulin resistance in the pathogenesis of type…”
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Exploring Visceral and Subcutaneous Adipose Tissue Secretomes in Human Obesity: Implications for Metabolic Disease by Kahn, Darcy, Macias, Emily, Zarini, Simona, Garfield, Amanda, Zemski Berry, Karin, MacLean, Paul, Gerszten, Robert E, Libby, Andrew, Solt, Claudia, Schoen, Jonathan, Bergman, Bryan C

“…Abstract Adipose tissue secretions are depot-specific and vary based on anatomical location. Considerable attention has been focused on visceral (VAT) and…”
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Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans by Bergman, Bryan C, Brozinick, Joseph T, Strauss, Allison, Bacon, Samantha, Kerege, Anna, Bui, Hai Hoang, Sanders, Phil, Siddall, Parker, Kuo, Ming Shang, Perreault, Leigh

“…Ceramides and sphingolipids are a family of lipid molecules that circulate in serum and accumulate in skeletal muscle, promoting insulin resistance. Plasma…”
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Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes by Cree-Green, Melanie, Bergman, Bryan C, Cengiz, Eda, Fox, Larry A, Hannon, Tamara S, Miller, Kellee, Nathan, Brandon, Pyle, Laura, Kahn, Darcy, Tansey, Michael, Tichy, Eileen, Tsalikian, Eva, Libman, Ingrid, Nadeau, Kristen J

“…Abstract Context Type 1 diabetes in adolescence is characterized by insulin deficiency and insulin resistance (IR), both thought to increase cardiovascular…”
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HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance by Robinson, Emma L, Bagchi, Rushita A, Major, Jennifer L, Bergman, Bryan C, Matsuda, Jennifer L, McKinsey, Timothy A

“…Stimulation of adipocyte β-adrenergic receptors (β-ARs) induces expression of uncoupling protein 1 (UCP1), promoting nonshivering thermogenesis. Association of…”
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ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway by Mukhopadhyay, Subhadip, Schlaepfer, Isabel R., Bergman, Bryan C., Panda, Prashanta Kumar, Praharaj, Prakash Priyadarshi, Naik, Prajna Paramita, Agarwal, Rajesh, Bhutia, Sujit Kumar

“…Understanding the dynamics of autophagy and apoptosis crosstalk in cancer progression remains a challenging task. Here, we reported how the autophagy protein…”
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Deoxysphingolipids - atypical skeletal muscle lipids related to insulin resistance in humans that decrease insulin sensitivity in vitro by Zarini, Simona, Zemski Berry, Karin A, Kahn, Darcy E, Garfield, Amanda, Perreault, Leigh, Kerege, Anna, Bergman, Bryan C

“…Sphingolipids are thought to promote skeletal muscle insulin resistance. 1-Deoxysphingolipids (dSL) are atypical sphingolipids that are increased in plasma of…”
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Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance by Cree-Green, Melanie, Stuppy, Jacob J, Thurston, Jessica, Bergman, Bryan C, Coe, Gregory V, Baumgartner, Amy D, Bacon, Samantha, Scherzinger, Ann, Pyle, Laura, Nadeau, Kristen J

“…Adolescents with type 1 diabetes (T1D) have difficulty obtaining optimal glucose control, which may relate to insulin resistance (IR), especially during…”
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Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro by Zarini, Simona, Brozinick, Joseph T., Zemski Berry, Karin A., Garfield, Amanda, Perreault, Leigh, Kerege, Anna, Bui, Hai Hoang, Sanders, Phil, Siddall, Parker, Kuo, Ming Shang, Bergman, Bryan C.

“…Serum ceramides, especially C16:0 and C18:0 species, are linked to CVD risk and insulin resistance, but details of this association are not well understood. We…”
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