Prevalence and antifungal susceptibility of Candida parapsilosis complex isolates collected from oral cavities of HIV-infected individuals

At present, few data are available on the prevalence and antifungal susceptibility of Candida parapsilosis complex isolates from HIV-infected individuals. The C. parapsilosis complex comprises three species, C. parapsilosis sensu stricto, C. metapsilosis and C. orthopsilosis. Fifteen of 318 Candida...

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Published in:	Journal of medical microbiology Vol. 61; no. 12; pp. 1758 - 1765
Main Authors:	MORIS, D. V, MELHEM, M. S. C, MARTINS, M. A, SOUZA, L. R, KACEW, S, SZESZS, M. W, CARVALHO, L. R, PIMENTA-RODRIGUES, M. V, BERGHS, H. A. M, MENDES, R. P
Format:	Journal Article
Language:	English
Published:	Reading Society for General Microbiology 01-12-2012
Subjects:	Amphotericin B - pharmacology Antifungal Agents - pharmacology Biological and medical sciences Candida - classification Candida - drug effects Candida - isolation & purification Candidiasis, Oral - complications Candidiasis, Oral - drug therapy Candidiasis, Oral - microbiology Caspofungin Echinocandins - pharmacology Female Fluconazole - pharmacology Fundamental and applied biological sciences. Psychology HIV Infections - complications HIV Infections - microbiology Human viral diseases Humans Infectious diseases Lipopeptides Male Medical sciences Microbial Sensitivity Tests Microbiology Miscellaneous Mouth - microbiology Mycological Typing Techniques Mycology Polymorphism, Restriction Fragment Length Pyrimidines - pharmacology Triazoles - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Voriconazole Immunopathology Yeast Prevalence AIDS Immune deficiency Epidemiology Candida parapsilosis Fungi Infection Oral cavity Antifungal agent Sensitivity Viral disease Isolate Fungi Imperfecti
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Summary:	At present, few data are available on the prevalence and antifungal susceptibility of Candida parapsilosis complex isolates from HIV-infected individuals. The C. parapsilosis complex comprises three species, C. parapsilosis sensu stricto, C. metapsilosis and C. orthopsilosis. Fifteen of 318 Candida isolates were identified as members of the C. parapsilosis complex by PCR and restriction fragment length polymorphism (RFLP). The prevalence of C. parapsilosis complex isolates was 4.7 %, 2.2 % being identified as C. parapsilosis sensu stricto and 2.5 % as C. metapsilosis, while no C. orthopsilosis was isolated. This is believed to be the first study that has identified isolates of C. metapsilosis obtained from the oral cavity of HIV-infected individuals. Antifungal susceptibility tests indicated that all the isolates were susceptible to amphotericin B (AMB), fluconazole (FLC), ketoconazole (KTC), itraconazole (ITC), voriconazole (VRC) and caspofungin (CASPO). Although isolates of C. parapsilosis sensu stricto and C. metapsilosis were susceptible to FLC, isolates of C. metapsilosis showed a tendency for higher MICs (≥1.0 µg ml(-1)). Based upon the frequency of candidiasis and the fact that certain isolates of the C. parapsilosis complex respond differently to FLC therapy, our data may be of therapeutic relevance with respect to susceptibility and potential resistance to specific antifungal agents. Our data suggest that C. metapsilosis can be a human commensal; its importance as a pathogen has yet to be confirmed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2615 1473-5644
DOI:	10.1099/jmm.0.045112-0