Search Results - "BERGER, Franklin G"

Early-onset colorectal cancer: initial clues and current views by Hofseth, Lorne J., Hebert, James R., Chanda, Anindya, Chen, Hexin, Love, Bryan L., Pena, Maria M., Murphy, E. Angela, Sajish, Mathew, Sheth, Amit, Buckhaults, Phillip J., Berger, Franklin G.

“…Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in patients <50 years old) has increased at an alarming rate. Although…”
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The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response by Zhang, Xinna, Wan, Guohui, Berger, Franklin G., He, Xiaoming, Lu, Xiongbin

“…The DNA damage response involves a complex network of processes that detect and repair DNA damage. Here we show that miRNA biogenesis is globally induced upon…”
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USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 by Zhang, Xinna, Berger, Franklin G, Yang, Jianhua, Lu, Xiongbin

“…Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF‐BP1…”
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Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway by XINNA ZHANG, GUOHUI WAN, MLOTSHWA, Sizolwenkosi, VANCE, Vicki, BERGER, Franklin G, HEXIN CHEN, XIONGBIN LU

“…Wild-type p53-induced phosphatase 1 (Wip1) was identified as an oncogene amplified and overexpressed in several human cancers. Recent evidence suggested that…”
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Novel Approaches to Colorectal Cancer by Berger, Franklin G, Boland, C. Richard

“…Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research…”
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HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease by Chandrashekaran, Varun, Seth, Ratanesh K., Dattaroy, Diptadip, Alhasson, Firas, Ziolenka, Jacek, Carson, James, Berger, Franklin G., Kalyanaraman, Balaraman, Diehl, Anna Mae, Chatterjee, Saurabh

“…Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver…”
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Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1 by McClellan, Jamie L, Davis, J Mark, Steiner, Jennifer L, Enos, Reilly T, Jung, Seung H, Carson, James A, Pena, Maria M, Carnevale, Kevin A, Berger, Franklin G, Murphy, E Angela

“…Tumor-associated macrophages are associated with poor prognosis in certain cancers. Monocyte chemoattractant protein 1 (MCP-1) is thought to be the most…”
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Hemoglobin and Its Scavenger Protein Haptoglobin Associate with ApoA-1-containing Particles and Influence the Inflammatory Properties and Function of High Density Lipoprotein by Watanabe, Junji, Grijalva, Victor, Hama, Susan, Barbour, Karen, Berger, Franklin G., Navab, Mohamad, Fogelman, Alan M., Reddy, Srinivasa T.

“…Hemoglobin (Hb) uniquely associates with proinflammatory HDL in atherogenic mice and coronary heart disease (CHD) patients. In this paper, we report that Hb…”
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The acute phase protein haptoglobin regulates host immunity by Huntoon, Kristin M., Wang, Yanping, Eppolito, Cheryl A., Barbour, Karen W., Berger, Franklin G., Shrikant, Protul A., Baumann, Heinz

“…The contribution of acute phase plasma proteins to host immune responses remains poorly characterized. To better understand the role of the acute phase…”
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Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells by Misra, Suniti, Obeid, Lina M., Hannun, Yusuf A., Minamisawa, Susumu, Berger, Franklin G., Markwald, Roger R., Toole, Bryan P., Ghatak, Shibnath

“…Hyaluronan is a major component of the pericellular matrix surrounding tumor cells, including colon carcinomas. Elevated cycooxygenase-2 levels have been…”
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Cooperation between an Intrinsically Disordered Region and a Helical Segment Is Required for Ubiquitin-independent Degradation by the Proteasome by Melo, Sandra P., Barbour, Karen W., Berger, Franklin G.

“…The 26 S proteasomal complex, which is responsible for the bulk of protein degradation within the cell, recognizes its target substrates via covalently linked…”
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Functional dissection of the N-terminal degron of human thymidylate synthase by Melo, Sandra P, Yoshida, Asami, Berger, Franklin G

“…Human thymidylate synthase (hTS; EC 2.1.1.45) is one of a small group of proteasomal substrates whose intracellular degradation occurs in a…”
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The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway by Peña, Maria Marjorette O., Melo, Sandra P., Xing, Yang-Yang, White, Kenneth, Barbour, Karen W., Berger, Franklin G.

“…The ubiquitin-independent proteasomal degradation pathway is increasingly being recognized as important in regulation of protein turnover in eukaryotic cells…”
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Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis by Tolosano, Emanuela, Fagoonee, Sharmila, Hirsch, Emilio, Berger, Franklin G., Baumann, Heinz, Silengo, Lorenzo, Altruda, Fiorella

“…Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among…”
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Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase by Peña, Maria Marjorette O, Xing, Yang Yang, Koli, Sangita, Berger, Franklin G

“…Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during…”
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Expression of cyclic guanosine monophosphate‐dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis by Kwon, In‐Kiu, Schoenlein, Patricia V., Delk, Jennifer, Liu, Kebin, Thangaraju, Muthusmy, Dulin, Nickolai O., Ganapathy, Vadivel, Berger, Franklin G., Browning, Darren D.

“…BACKGROUND Type 1 cyclic guanosine monophosphate (cGMP)‐dependent protein kinase (PKG) reportedly has exhibited antitumor properties, and its expression is…”
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Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice by Blum, Shany, MD, MSc, Asaf, Roy, Guetta, Julia, PhD, Miller-Lotan, Rachel, PhD, Asleh, Rabea, MSc, Kremer, Ran, MD, Levy, Nina S., PhD, Berger, Franklin G., MD, PhD, Aronson, Doron, MD, Fu, Xiaoming, PhD, Zhang, Renliang, PhD, Hazen, Stanley L., MD, PhD, Levy, Andrew P., MD, PhD, FACC

“…Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice Shany Blum, Roy Asaf, Julia Guetta, Rachel Miller-Lotan, Rabea Asleh, Ran Kremer, Nina…”
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Thymidylate synthase as a chemotherapeutic drug target: Where are we after fifty years? by Berger, Franklin G., Berger, Sondra H.

“…Commentary to: A Proposed Clinical Test for Monitoring Fluoropyrimidine Therapy: Detection and Stability of Thymidylate Synthase Ternary Complexes J.R. Brody,…”
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Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase by Barbour, Karen W, Xing, Yang-Yang, Peña, Edsel A, Berger, Franklin G

“…TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Previous studies have shown that…”
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Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression by Kaur, Kamaljeet, Saxena, Arpit, Debnath, Irina, O'Brien, Jacqueline L., Ajami, Nadim J., Auchtung, Thomas A., Petrosino, Joseph F., Sougiannis, Alexander‐Jacques, Depaep, Sarah, Chumanevich, Alexander, Gummadidala, Phani M., Omebeyinje, Mayomi H., Banerjee, Sourav, Chatzistamou, Ioulia, Chakraborty, Paramita, Fayad, Raja, Berger, Franklin G., Carson, James A., Chanda, Anindya

“…Recent epidemiological evidence suggests that exposure to antibiotics in early‐to‐middle adulthood is associated with an increased risk of colorectal adenoma…”
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