Search Results - "BERALDI, DARIO"

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution by Booth, Michael J., Marsico, Giovanni, Bachman, Martin, Beraldi, Dario, Balasubramanian, Shankar

“…Recently, the cytosine modifications 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) were found to exist in the genomic deoxyribonucleic acid (DNA)…”
Get full text

G-quadruplex structures are stable and detectable in human genomic DNA by Lam, Enid Yi Ni, Beraldi, Dario, Tannahill, David, Balasubramanian, Shankar

Get full text

Genome-wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population by JOHNSTON, SUSAN E., McEWAN, JOHN C., PICKERING, NATALIE K., KIJAS, JAMES W., BERALDI, DARIO, PILKINGTON, JILL G., PEMBERTON, JOSEPHINE M., SLATE, JON

“…Understanding the genetic architecture of phenotypic variation in natural populations is a fundamental goal of evolutionary genetics. Wild Soay sheep (Ovis…”
Get full text

FOXM1 binds directly to non-consensus sequences in the human genome by Sanders, Deborah A, Gormally, Michael V, Marsico, Giovanni, Beraldi, Dario, Tannahill, David, Balasubramanian, Shankar

“…The Forkhead (FKH) transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in most types of cancer. FOXM1, similar to other FKH…”
Get full text

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients by Silva-Filho, João L, Dos-Santos, João Ck, Judice, Carla, Beraldi, Dario, Venugopal, Kannan, Lima, Diogenes, Nakaya, Helder I, De Paula, Erich V, Lopes, Stefanie Cp, Lacerda, Marcus Vg, Marti, Matthias, Costa, Fabio Tm

“…is the major cause of human malaria in the Americas. How infection can lead to poor clinical outcomes, despite low peripheral parasitaemia, remains a matter of…”
Get full text

Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array) by Field, Sarah F, Beraldi, Dario, Bachman, Martin, Stewart, Sabrina K, Beck, Stephan, Balasubramanian, Shankar

“…The Infinium 450K Methylation array is an established tool for measuring methylation. However, the bisulfite (BS) reaction commonly used with the 450K array…”
Get full text

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication by Damasceno, Jeziel D, Reis-Cunha, João, Crouch, Kathryn, Beraldi, Dario, Lapsley, Craig, Tosi, Luiz R O, Bartholomeu, Daniella, McCulloch, Richard

“…Homologous recombination (HR) has an intimate relationship with genome replication, both during repair of DNA lesions that might prevent DNA synthesis and in…”
Get full text

Structural and functional annotation of the porcine immunome by Dawson, Harry D, Loveland, Jane E, Pascal, Géraldine, Gilbert, James G R, Uenishi, Hirohide, Mann, Katherine M, Sang, Yongming, Zhang, Jie, Carvalho-Silva, Denise, Hunt, Toby, Hardy, Matthew, Hu, Zhiliang, Zhao, Shu-Hong, Anselmo, Anna, Shinkai, Hiroki, Chen, Celine, Badaoui, Bouabid, Berman, Daniel, Amid, Clara, Kay, Mike, Lloyd, David, Snow, Catherine, Morozumi, Takeya, Cheng, Ryan Pei-Yen, Bystrom, Megan, Kapetanovic, Ronan, Schwartz, John C, Kataria, Ranjit, Astley, Matthew, Fritz, Eric, Steward, Charles, Thomas, Mark, Wilming, Laurens, Toki, Daisuke, Archibald, Alan L, Bed'Hom, Bertrand, Beraldi, Dario, Huang, Ting-Hua, Ait-Ali, Tahar, Blecha, Frank, Botti, Sara, Freeman, Tom C, Giuffra, Elisabetta, Hume, David A, Lunney, Joan K, Murtaugh, Michael P, Reecy, James M, Harrow, Jennifer L, Rogel-Gaillard, Claire, Tuggle, Christopher K

“…The domestic pig is known as an excellent model for human immunology and the two species share many pathogens. Susceptibility to infectious disease is one of…”
Get full text

Comparative analysis of monocyte subsets in the pig by Fairbairn, Lynsey, Kapetanovic, Ronan, Beraldi, Dario, Sester, David P, Tuggle, Chris K, Archibald, Alan L, Hume, David A

“…Human and mouse monocyte can be divided into two different subpopulations based on surface marker expression: CD14/16 and Ly6C/CX3CR1, respectively. Monocyte…”
Get full text

Revealing the History of Sheep Domestication Using Retrovirus Integrations by Chessa, Bernardo, Pereira, Filipe, Arnaud, Frederick, Amorim, Antonio, Goyache, Félix, Mainland, Ingrid, Kao, Rowland R, Pemberton, Josephine M, Beraldi, Dario, Stear, Michael J, Alberti, Alberto, Pittau, Marco, Iannuzzi, Leopoldo, Banabazi, Mohammad H, Kazwala, Rudovick R, Zhang, Ya-ping, Arranz, Juan J, Ali, Bahy A, Wang, Zhiliang, Uzun, Metehan, Dione, Michel M, Olsaker, Ingrid, Holm, Lars-Erik, Saarma, Urmas, Ahmad, Sohail, Marzanov, Nurbiy, Eythorsdottir, Emma, Holland, Martin J, Ajmone-Marsan, Paolo, Bruford, Michael W, Kantanen, Juha, Spencer, Thomas E, Palmarini, Massimo

“…The domestication of livestock represented a crucial step in human history. By using endogenous retroviruses as genetic markers, we found that sheep…”
Get full text

Performance of Marker-Based Relatedness Estimators in Natural Populations of Outbred Vertebrates by Csillery, Katalin, Johnson, Toby, Beraldi, Dario, Clutton-Brock, Tim, Coltman, Dave, Hansson, Bengt, Spong, Goran, Pemberton, Josephine M

“…Knowledge of relatedness between pairs of individuals plays an important role in many research areas including evolutionary biology, quantitative genetics, and…”
Get full text

A gene expression atlas of the domestic pig by Freeman, Tom C, Ivens, Alasdair, Baillie, J Kenneth, Beraldi, Dario, Barnett, Mark W, Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I, Summers, Kim M, Tuggle, Christopher K, Archibald, Alan L, Hume, David A

“…This work describes the first genome-wide analysis of the transcriptional landscape of the pig. A new porcine Affymetrix expression array was designed in order…”
Get full text

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication by Damasceno, Jeziel Dener, Marques, Catarina A, Beraldi, Dario, Crouch, Kathryn, Lapsley, Craig, Obonaga, Ricardo, Tosi, Luiz Ro, McCulloch, Richard

“…DNA replication is needed to duplicate a cell's genome in S phase and segregate it during cell division. Previous work in detected DNA replication initiation…”
Get full text

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites by Hunt, Paul, Martinelli, Axel, Modrzynska, Katarzyna, Borges, Sofia, Creasey, Alison, Rodrigues, Louise, Beraldi, Dario, Loewe, Laurence, Fawcett, Richard, Kumar, Sujai, Thomson, Marian, Trivedi, Urmi, Otto, Thomas D, Pain, Arnab, Blaxter, Mark, Cravo, Pedro

“…Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or…”
Get full text

Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments by McInroy, Gordon R, Beraldi, Dario, Raiber, Eun-Ang, Modrzynska, Katarzyna, van Delft, Pieter, Billker, Oliver, Balasubramanian, Shankar

“…Bisulfite sequencing is a valuable tool for mapping the position of 5-methylcytosine in the genome at single base resolution. However, the associated chemical…”
Get full text

Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling by Dreyer, Stephan B, Jamieson, Nigel B, Evers, Lisa, Duthie, Fraser, Cooke, Susie, Marshall, John, Beraldi, Dario, Knight, Stephen, Upstill-Goddard, Rosanna, Dickson, Euan J, Carter, C Ross, McKay, Colin J, Biankin, Andrew V, Chang, David K

“…Next-generation sequencing is enabling molecularly guided therapy for many cancer types, yet failure rates remain relatively high in pancreatic cancer (PC)…”
Get full text

Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep ( Ovis aries) by Beraldi, Dario, McRae, Allan F., Gratten, Jacob, Pilkington, Jill G., Slate, Jon, Visscher, Peter M., Pemberton, Josephine M.

“…A genome-wide scan was performed to detect quantitative trait loci (QTL) for resistance to gastrointestinal parasites and ectoparasitic keds segregating in the…”
Get full text

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma by Raiber, Eun-Ang, Beraldi, Dario, Martínez Cuesta, Sergio, McInroy, Gordon R., Kingsbury, Zoya, Becq, Jennifer, James, Terena, Lopes, Margarida, Allinson, Kieren, Field, Sarah, Humphray, Sean, Santarius, Thomas, Watts, Colin, Bentley, David, Balasubramanian, Shankar

“…Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first…”
Get full text

MAPPING QUANTITATIVE TRAIT LOCI UNDERLYING FITNESS-RELATED TRAITS IN A FREE-LIVING SHEEP POPULATION by Beraldi, Dario, McRae, Allan F, Gratten, Jacob, Slate, Jon, Visscher, Peter M, Pemberton, Josephine M

“…We searched for quantitative trait loci (QTL) underlying fitness-related traits in a free-living pedigree of 588 Soay sheep in which a genetic map using 251…”
Get full text

Prediction of altered 3'- UTR miRNA-binding sites from RNA-Seq data: the swine leukocyte antigen complex (SLA) as a model region by Endale Ahanda, Marie-Laure, Fritz, Eric R, Estellé, Jordi, Hu, Zhi-Liang, Madsen, Ole, Groenen, Martien A M, Beraldi, Dario, Kapetanovic, Ronan, Hume, David A, Rowland, Robert R R, Lunney, Joan K, Rogel-Gaillard, Claire, Reecy, James M, Giuffra, Elisabetta

“…THE SLA (swine leukocyte antigen, MHC: SLA) genes are the most important determinants of immune, infectious disease and vaccine response in pigs; several…”
Get full text