Search Results - "BENUSSI, Luisa"

Digital Detection of Exosomes by Interferometric Imaging by Daaboul, George G., Gagni, Paola, Benussi, Luisa, Bettotti, Paolo, Ciani, Miriam, Cretich, Marina, Freedman, David S., Ghidoni, Roberta, Ozkumur, Ayca Yalcin, Piotto, Chiara, Prosperi, Davide, Santini, Benedetta, Ünlü, M. Selim, Chiari, Marcella

“…Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis,…”
Get full text

Extracellular vesicles in Alzheimer's disease: friends or foes? Focus on aβ-vesicle interaction by Joshi, Pooja, Benussi, Luisa, Furlan, Roberto, Ghidoni, Roberta, Verderio, Claudia

“…The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing attention in Alzheimer's disease (AD). Among other transfer modes, Aβ and…”
Get full text

Genome Wide Association Study and Next Generation Sequencing: A Glimmer of Light Toward New Possible Horizons in Frontotemporal Dementia Research by Ciani, Miriam, Benussi, Luisa, Bonvicini, Cristian, Ghidoni, Roberta

“…Frontotemporal Dementia (FTD) is a focal neurodegenerative disease, with a strong genetic background, that causes early onset dementia. The present knowledge…”
Get full text

Tau Mutations Serve as a Novel Risk Factor for Cancer by Rossi, Giacomina, Redaelli, Veronica, Contiero, Paolo, Fabiano, Sabrina, Tagliabue, Giovanna, Perego, Paola, Benussi, Luisa, Bruni, Amalia C, Filippini, Graziella, Farinotti, Mariangela, Giaccone, Giorgio, Buiatiotis, Simona, Manzoni, Claudia, Ferrari, Raffaele, Tagliavini, Fabrizio

“…In addition to its well-recognized role in neurodegeneration, tau participates in maintenance of genome stability and chromosome integrity. In particular,…”
Get full text

Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? by Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta

“…Recent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases. In…”
Get full text

Clinical and biomarker changes in presymptomatic genetic frontotemporal dementia by Benussi, Alberto, Gazzina, Stefano, Premi, Enrico, Cosseddu, Maura, Archetti, Silvana, Dell’Era, Valentina, Cantoni, Valentina, Cotelli, Maria Sofia, Alberici, Antonella, Micheli, Anna, Benussi, Luisa, Ghidoni, Roberta, Padovani, Alessandro, Borroni, Barbara

“…Presymptomatic carriers of GRN and C9orf72 mutations, the most frequent genetic causes of frontotemporal lobar degeneration, represent the optimal target…”
Get full text

Exploring Neurofilament Light Chain and Exosomes in the Genetic Forms of Frontotemporal Dementia by Zanardini, Roberta, Saraceno, Claudia, Benussi, Luisa, Squitti, Rosanna, Ghidoni, Roberta

“…Differential diagnosis of neurological disorders and their subtype classification are challenging without specific biomarkers. Genetic forms of these…”
Get full text

Molecular subtypes of Alzheimer’s disease by Di Fede, Giuseppe, Catania, Marcella, Maderna, Emanuela, Ghidoni, Roberta, Benussi, Luisa, Tonoli, Elisa, Giaccone, Giorgio, Moda, Fabio, Paterlini, Anna, Campagnani, Ilaria, Sorrentino, Stefano, Colombo, Laura, Kubis, Adriana, Bistaffa, Edoardo, Ghetti, Bernardino, Tagliavini, Fabrizio

“…Protein misfolding and aggregation is a central feature of several neurodegenerative disorders including Alzheimer’s disease (AD), in which assemblies of…”
Get full text

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease by Squitti, Rosanna, Ghidoni, Roberta, Siotto, Mariacristina, Ventriglia, Mariacarla, Benussi, Luisa, Paterlini, Anna, Magri, Mariachiara, Binetti, Giuliano, Cassetta, Emanuele, Caprara, Deborah, Vernieri, Fabrizio, Rossini, Paolo M., Pasqualetti, Patrizio

“…Objective Meta‐analyses show that nonbound ceruloplasmin (non‐Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer…”
Get full text

Regulatory miRNAs in Cardiovascular and Alzheimer's Disease: A Focus on Copper by Sacco, Anna, Martelli, Fabio, Pal, Amit, Saraceno, Claudia, Benussi, Luisa, Ghidoni, Roberta, Rongioletti, Mauro, Squitti, Rosanna

“…Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), are key regulators of differentiation and development. In the cell, transcription factors regulate the…”
Get full text

Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants by Squitti, Rosanna, Ventriglia, Mariacarla, Simonelli, Ilaria, Bonvicini, Cristian, Costa, Alfredo, Perini, Giulia, Binetti, Giuliano, Benussi, Luisa, Ghidoni, Roberta, Koch, Giacomo, Borroni, Barbara, Albanese, Alberto, Sensi, Stefano L, Rongioletti, Mauro

“…Evidence indicates that patients with Alzheimer's dementia (AD) show signs of copper (Cu) dyshomeostasis. This study aimed at evaluating the potential of Cu…”
Get full text

MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer's Disease by Serpente, Maria, Fenoglio, Chiara, D'Anca, Marianna, Arcaro, Marina, Sorrentino, Federica, Visconte, Caterina, Arighi, Andrea, Fumagalli, Giorgio G, Porretti, Laura, Cattaneo, Alessandra, Ciani, Miriam, Zanardini, Roberta, Benussi, Luisa, Ghidoni, Roberta, Scarpini, Elio, Galimberti, Daniela

“…Small extracellular vesicles (EVs) are able to pass from the central nervous system (CNS) into peripheral blood and contain molecule markers of their parental…”
Get full text

The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes by Ciani, Miriam, Bonvicini, Cristian, Scassellati, Catia, Carrara, Matteo, Maj, Carlo, Fostinelli, Silvia, Binetti, Giuliano, Ghidoni, Roberta, Benussi, Luisa

“…Frontotemporal dementia (FTD) is a common form of dementia among early-onset cases. Several genetic factors for FTD have been revealed, but a large proportion…”
Get full text

Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease by Rosas, Irene, Martínez, Carmen, Clarimón, Jordi, Lleó, Alberto, Illán-Gala, Ignacio, Dols-Icardo, Oriol, Borroni, Barbara, Almeida, Maria Rosário, van der Zee, Julie, Van Broeckhoven, Christine, Bruni, Amalia C., Anfossi, Maria, Bernardi, Livia, Maletta, Raffaele, Serpente, María, Galimberti, Daniela, Scarpini, Elio, Rossi, Giacomina, Caroppo, Paola, Benussi, Luisa, Ghidoni, Roberta, Binetti, Giuliano, Nacmias, Benedetta, Sorbi, Sandro, Piaceri, Irene, Bagnoli, Silvia, Antonell, Anna, Sánchez-Valle, Raquel, De la Casa-Fages, Beatriz, Grandas, Francisco, Diez-Fairen, Mónica, Pastor, Pau, Ferrari, Raffaele, Álvarez, Victoria, Menéndez-González, Manuel

“…We analyzed the frequency of intermediate alleles (IAs) in the ATXN1, ATXN2, and HTT genes in several neurodegenerative diseases. The study included 1126…”
Get full text

Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a GRN Mutation by Cimini, Sara, Bellini, Sonia, Saraceno, Claudia, Benussi, Luisa, Ghidoni, Roberta, Giliani, Silvia Clara, Puoti, Gianfranco, Canafoglia, Laura, Giaccone, Giorgio, Rossi, Giacomina

“…Frontotemporal lobar degeneration (FTLD) is a complex disease, characterized by progressive degeneration of frontal and temporal lobes. Mutations in…”
Get full text

The PINK1 p.Asn521Thr Variant Is Associated with Earlier Disease Onset in GRN/C9orf72 Frontotemporal Lobar Degeneration by Rossi, Giacomina, Salvi, Erika, Benussi, Luisa, Mehmeti, Elkadia, Geviti, Andrea, Bellini, Sonia, Longobardi, Antonio, Facconi, Alessandro, Carrara, Matteo, Bonvicini, Cristian, Nicsanu, Roland, Saraceno, Claudia, Ricci, Martina, Giaccone, Giorgio, Binetti, Giuliano, Ghidoni, Roberta

“…Genetic frontotemporal lobar degeneration (FTLD) is characterized by heterogeneous phenotypic expression, with a disease onset highly variable even in patients…”
Get full text

Plasma Small Extracellular Vesicle Cathepsin D Dysregulation in GRN/C9orf72 and Sporadic Frontotemporal Lobar Degeneration by Bellini, Sonia, Saraceno, Claudia, Benussi, Luisa, Geviti, Andrea, Longobardi, Antonio, Nicsanu, Roland, Cimini, Sara, Ricci, Martina, Canafoglia, Laura, Coppola, Cinzia, Puoti, Gianfranco, Binetti, Giuliano, Rossi, Giacomina, Ghidoni, Roberta

“…Emerging data suggest the roles of endo-lysosomal dysfunctions in frontotemporal lobar degeneration (FTLD) and in other dementias. Cathepsin D is one of the…”
Get full text

A novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia by Palluzzi, Fernando, Ferrari, Raffaele, Graziano, Francesca, Novelli, Valeria, Rossi, Giacomina, Galimberti, Daniela, Rainero, Innocenzo, Benussi, Luisa, Nacmias, Benedetta, Bruni, Amalia C, Cusi, Daniele, Salvi, Erika, Borroni, Barbara, Grassi, Mario

“…Frontotemporal Dementia (FTD) is the form of neurodegenerative dementia with the highest prevalence after Alzheimer's disease, equally distributed in men and…”
Get full text

N-Terminally Truncated and Pyroglutamate-Modified Aβ Forms Are Measurable in Human Cerebrospinal Fluid and Are Potential Markers of Disease Progression in Alzheimer’s Disease by Domingo, Guido, Benussi, Luisa, Saraceno, Claudia, Bertuzzi, Michela, Nicsanu, Roland, Longobardi, Antonio, Bellini, Sonia, Cagnotto, Alfredo, Salmona, Mario, Binetti, Giuliano, Ghidoni, Roberta

“…Alzheimer’s disease (AD) is a pathology characterized by the accumulation in the brain of intracellular and extracellular amyloid-β (Aβ) aggregates, especially…”
Get full text

Prodromal frontotemporal dementia: clinical features and predictors of progression by Benussi, Alberto, Ashton, Nicholas J, Karikari, Thomas K, Alberici, Antonella, Saraceno, Claudia, Ghidoni, Roberta, Benussi, Luisa, Zetterberg, Henrik, Blennow, Kaj, Borroni, Barbara

“…The prodromal phase of frontotemporal dementia (FTD) is still not well characterized, and conversion rates to dementia and predictors of progression at 1-year…”
Get full text