Search Results - "BENTLEY, Amy"

Health Disparities in Cardiometabolic Traits: Genomics, Gaps, and Paradoxes by Bentley, Amy R.

“…Cardiometabolic traits vary considerably across ancestry groups, creating interest in disentangling the contributing factors to minimize health disparities…”
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Brother Herman Zaccarelli and the influence of Vatican II on Catholic institutional food service by Bentley, Amy

“…In post-World War II United States, a Holy Cross monk named Herman Zaccarelli viewed Vatican II as an opening for the modernising of food in Catholic religious…”
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Diversity and inclusion in genomic research: why the uneven progress? by Bentley, Amy R., Callier, Shawneequa, Rotimi, Charles N.

“…Conducting genomic research in diverse populations has led to numerous advances in our understanding of human history, biology, and health disparities, in…”
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Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes by Chen, Guanjie, Shriner, Daniel, Zhang, Jianhua, Zhou, Jie, Adikaram, Poorni, Doumatey, Ayo P, Bentley, Amy R, Adeyemo, Adebowale, Rotimi, Charles N

“…Impaired glucose tolerance is a major risk factor for type 2 diabetes (T2D) and several cardiometabolic disorders. To identify genetic loci underlying fasting…”
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The genomic landscape of African populations in health and disease by Rotimi, Charles N, Bentley, Amy R, Doumatey, Ayo P, Chen, Guanjie, Shriner, Daniel, Adeyemo, Adebowale

“…A deeper appreciation of the complex architecture of African genomes is critical to the global effort to understand human history, biology and differential…”
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Evaluating the promise of inclusion of African ancestry populations in genomics by Bentley, Amy R., Callier, Shawneequa L., Rotimi, Charles N.

“…The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are…”
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Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations by Hayat, Mahtaab, Kerr, Robyn, Bentley, Amy R, Rotimi, Charles N, Raal, Frederick J, Ramsay, Michèle

“…Non-communicable diseases, including cardiovascular diseases (CVDs), are increasing in African populations. High serum low density lipoprotein cholesterol…”
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Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017 by Liu, Chang, Yuan, Ying-Chao, Guo, Mo-Ning, Xin, Zhong, Chen, Guan-Jie, Bentley, Amy R, Hua, Lin, Zheng, Jian-Peng, Ekoru, Kenneth, Yang, Jin-Kui

“…Previous reports of the annual incidence of type 1 diabetes (T1D) in China were conducted using retrospective hospital cases, which may not reflect the…”
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Correction: Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations by Hayat, Mahtaab, Kerr, Robyn, Bentley, Amy R, Rotimi, Charles N, Raal, Frederick J, Ramsay, Michèle

“…[This corrects the article DOI: 10.1371/journal.pone.0229098.]…”
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Unappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies by Gouveia, Mateus H., Bentley, Amy R., Leal, Thiago P., Tarazona-Santos, Eduardo, Bustamante, Carlos D., Adeyemo, Adebowale A., Rotimi, Charles N., Shriner, Daniel

“…European-ancestry populations are recognized as stratified but not as admixed, implying that residual confounding by locus-specific ancestry can affect studies…”
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Genes, environment, and African ancestry in cardiometabolic disorders by Doumatey, Ayo P., Bentley, Amy R., Akinyemi, Rufus, Olanrewaju, Timothy O., Adeyemo, Adebowale, Rotimi, Charles

“…Cardiometabolic diseases are rising in populations of African descent and have become the leading causes of death and disability in these…”
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The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research by Bentley, Amy R., Callier, Shawneequa, Rotimi, Charles

“…Individuals with African ancestry have the greatest genomic diversity in the world, yet they have been underrepresented in genomic research. To advance our…”
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An approach to identify gene-environment interactions and reveal new biological insight in complex traits by Zhu, Xiaofeng, Yang, Yihe, Lorincz-Comi, Noah, Li, Gen, Bentley, Amy R., de Vries, Paul S., Brown, Michael, Morrison, Alanna C., Rotimi, Charles N., Gauderman, W. James, Rao, Dabeeru C., Aschard, Hugues

“…There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to…”
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Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals by Bentley, Amy R., Doumatey, Ayo P., Zhou, Jie, Lei, Lin, Meeks, Karlijn A. C., Heuston, Elisabeth F., Rotimi, Charles N., Adeyemo, Adebowale A.

“…Elevated triglycerides (TG) are a risk factor for cardiometabolic disorders. There are limited data on lipidomics profiles associated with serum triglycerides…”
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Genetic risk scores for cardiometabolic traits in sub-Saharan African populations by Ekoru, Kenneth, Adeyemo, Adebowale A, Chen, Guanjie, Doumatey, Ayo P, Zhou, Jie, Bentley, Amy R, Shriner, Daniel, Rotimi, Charles N

“…Abstract Background There is growing support for the use of genetic risk scores (GRS) in routine clinical settings. Due to the limited diversity of current…”
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ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response by Adeyemo, Adebowale A., Zaghloul, Norann A., Chen, Guanjie, Doumatey, Ayo P., Leitch, Carmen C., Hostelley, Timothy L., Nesmith, Jessica E., Zhou, Jie, Bentley, Amy R., Shriner, Daniel, Fasanmade, Olufemi, Okafor, Godfrey, Eghan, Benjamin, Agyenim-Boateng, Kofi, Chandrasekharappa, Settara, Adeleye, Jokotade, Balogun, William, Owusu, Samuel, Amoah, Albert, Acheampong, Joseph, Johnson, Thomas, Oli, Johnnie, Adebamowo, Clement, Collins, Francis, Dunston, Georgia, Rotimi, Charles N.

“…Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health…”
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Deriving stratified effects from joint models investigating gene-environment interactions by Laville, Vincent, Majarian, Timothy, de Vries, Paul S, Bentley, Amy R, Feitosa, Mary F, Sung, Yun J, Rao, D C, Manning, Alisa, Aschard, Hugues

“…Models including an interaction term and performing a joint test of SNP and/or interaction effect are often used to discover Gene-Environment (GxE)…”
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Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations by Bentley, Amy R., Rotimi, Charles N.

“…African Americans generally have a healthier lipid profile (lower triglycerides and higher high-density lipoprotein cholesterol concentration) compared with…”
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Reversing the tide — diagnosis and prevention of T2DM in populations of African descent by Utumatwishima, Jean N., Chung, Stephanie T., Bentley, Amy R., Udahogora, Margaret, Sumner, Anne E.

“…Key Points Although African, Caribbean and African-American populations are all groups of African descent, cultural and historical differences mean that…”
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Evolutionary forces in diabetes and hypertension pathogenesis in Africans by Meeks, Karlijn A C, Bentley, Amy R, Adeyemo, Adebowale A, Rotimi, Charles N

“…Abstract Rates of type 2 diabetes (T2D) and hypertension are increasing rapidly in urbanizing sub-Saharan Africa (SSA). While lifestyle factors drive the…”
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