Search Results - "BENOVIC, J. L"

Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia by Bychkov, E.R, Gurevich, V.V, Joyce, J.N, Benovic, J.L, Gurevich, E.V

“…Abstract Arrestins and G proteins-coupled receptor kinases (GRKs) regulate signaling and trafficking of G protein-coupled receptors. We investigated changes in…”
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Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to Gs and Gi by Chen, XP, Yang, W, Fan, Y, Luo, JS, Hong, K, Wang, Z, Yan, JF, Chen, X, Lu, JX, Benovic, JL, Zhou, NM

“…BACKGROUND AND PURPOSE The cannabinoid CB1 receptor is primarily thought to be functionally coupled to the Gi form of G proteins, through which it negatively…”
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Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development by Gurevich, E.V, Benovic, J.L, Gurevich, V.V

“…Arrestins are adaptor proteins involved in homologous desensitization and trafficking of G protein-coupled receptors. Arrestins bind to activated…”
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Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder by Bychkov, E.R, Ahmed, M.R, Gurevich, V.V, Benovic, J.L, Gurevich, E.V

“…Abstract Alterations of multiple G protein-mediated signaling pathways are detected in schizophrenia. G protein-coupled receptor kinases (GRKs) and arrestins…”
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G-protein-coupled receptor kinase activity is increased in hypertension by Gros, R, Benovic, J L, Tan, C M, Feldman, R D

“…Impaired vascular beta-adrenergic responsiveness may play an important role in the development and/or maintenance of hypertension. This defect has been…”
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Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin by GUREVICH, V. V, BENOVIC, J. L

“…Visual arrestin plays an important role in regulating light responsiveness via its ability to specifically bind to the phosphorylated and light-activated form…”
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l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain by Bezard, E., Gross, C.E., Qin, Li, Gurevich, V.V., Benovic, J.L., Gurevich, E.V.

“…Dysregulation of dopamine receptors (DARs) is believed to contribute to Parkinson disease (PD) pathology. G protein-coupled receptors (GPCR) undergo…”
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Deletion of the distal COOH‐terminus of the A2B adenosine receptor switches internalization to an arrestin‐ and clathrin‐independent pathway and inhibits recycling by Mundell, SJ, Matharu, A‐L, Nisar, S, Palmer, TM, Benovic, JL, Kelly, E

“…Background and purpose:  We have investigated the effect of deletions of a postsynaptic density, disc large and zo‐1 protein (PDZ) motif at the end of the…”
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Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors by Guigoni, C., Aubert, I., Li, Q., Gurevich, V.V., Benovic, J.L., Ferry, S., Mach, U., Stark, H., Leriche, L., Håkansson, K., Bioulac, Bernard H., Gross, Christian E., Sokoloff, Pierre, Fisone, Gilberto, Gurevich, E.V., Bloch, Bertrand, Bezard, Erwan

“…Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain…”
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Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death by Kook, S, Zhan, X, Cleghorn, W M, Benovic, J L, Gurevich, V V, Gurevich, E V

“…Apoptosis is programmed cell death triggered by activation of death receptors or cellular stress. Activation of caspases is the hallmark of apoptosis…”
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Cloning and Expression of GRK5: A Member of the G Protein-Coupled Receptor Kinase Family by Kunapuli, Priya, Benovic, Jeffrey L.

“…Guanine nucleotide binding protein (G-protein)-coupled receptor kinases (GRKs) specifically phosphorylate the agonist-occupied form of G-protein-coupled…”
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G-Protein–Coupled Receptor Kinase Activity in Hypertension: Increased Vascular and Lymphocyte G-Protein Receptor Kinase-2 Protein Expression by Gros, Robert, Chorazyczewski, Jozef, Meek, Murray D, Benovic, Jeffrey L, Ferguson, Stephen S. G, Feldman, Ross D

“…Impaired receptor-stimulated adenylyl cyclase activation has been observed in lymphocytes from hypertensive subjects and has been linked to an increase in…”
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Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family by BENOVIC, J. L, GOMEZ, J

“…G protein-coupled receptor kinases (GRK), such as the beta-adrenergic receptor kinase (beta ARK) and rhodopsin kinase, specifically phosphorylate the activated…”
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Mechanisms of Proliferation Synergy by Receptor Tyrosine Kinase and G Protein-Coupled Receptor Activation in Human Airway Smooth Muscle by Krymskaya, Vera P, Orsini, Michael J, Eszterhas, Andrew J, Brodbeck, Kristin C, Benovic, Jeffrey L, Panettieri, Reynold A., Jr, Penn, Raymond B

“…Despite recent studies depicting the capacity of G protein-coupled receptors (GPCRs) to activate mitogenic signaling pathways more commonly associated with…”
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Functional Desensitization of the Isolated β -adrenergic Receptor by the β -adrenergic Receptor Kinase: Potential Role of an Analog of the Retinal Protein Arrestin (48-kDa Protein) by Benovic, J. L., Kühn, H., Weyand, I., Codina, J., Caron, M. G., Lefkowitz, R. J.

“…The β -adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the β -adrenergic receptor only when it is…”
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β -adrenergic Receptor Kinase: Identification of a Novel Protein Kinase That Phosphorylates the Agonist-Occupied Form of the Receptor by Benovic, Jeffrey L., Strasser, Ruth H., Caron, Marc G., Lefkowitz, Robert J.

“…Agonist-promoted desensitization of adenylate cyclase is intimately associated with phosphorylation of the β -adrenergic receptor in mammalian, avian, and…”
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Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting by Marchese, Adriano, Benovic, Jeffrey L.

“…Ligand-induced trafficking plays an important role in the physiologic regulation of many G protein-coupled receptors (GPCRs). Although numerous GPCRs are…”
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Cell-free expression of visual arrestin. Truncation mutagenesis identifies multiple domains involved in rhodopsin interaction by Gurevich, V.V., Benovic, J.L.

“…Visual arrestin plays an important role in regulating light responsiveness via its ability to specifically bind to the phosphorylated and light-activated form…”
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Polypeptide variants of beta-arrestin and arrestin3 by STERNE-MARR, R, GUREVICH, V. V, GOLDSMITH, P, BODINE, R. C, SANDERS, C, DONOSO, L. A, BENOVIC, J. L

“…Retinal arrestin (S-antigen) inactivates the phototransduction cascade by binding to light-activated phosphorylated rhodopsin and thereby "arresting" coupling…”
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Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart by Eckhart, Andrea D, Duncan, Sandra J, Penn, Raymond B, Benovic, Jeffrey L, Lefkowitz, Robert J, Koch, Walter J

“…G protein–coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including α1B-adrenergic receptors (ARs), resulting in…”
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