Search Results - "BENNICELLI, Carlo"

Modulation of apoptosis by cancer chemopreventive agents by D'Agostini, Francesco, Izzotti, Alberto, Balansky, Roumen M, Bennicelli, Carlo, De Flora, Silvio

“…A review of almost 2000 studies showed that the large majority of 39 putative cancer chemopreventive agents induced "spontaneous" apoptosis. Inhibition of the…”
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Induction and Modulation of Lung Tumors: Genomic and Transcriptional Alterations in Cigarette Smoke-exposed Mice by De Flora, Silvio, Izzotti, Alberto, D'Agostini, Francesco, Bennicelli, Carlo, You, Ming, LubetRoumen, Ronald A., Balansky, M.

“…Cigarette smoke plays a major role in the epidemiology of lung cancer, and smoke components have extensively been investigated in carcinogenicity and…”
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Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine by De Flora, S, Astengo, M, Serra, D, Bennicelli, C

“…The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when…”
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In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds by De Flora, S, Bennicelli, C, Camoirano, A, Serra, D, Romano, M, Rossi, G A, Morelli, A, De Flora, A

“…N-acetylcysteine (NAC) was administered to rats in various combinations with an enzyme inducer (Aroclor 1254) and with depletors of reduced glutathione (GSH),…”
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epidemiological revolution of the 20th century by De Flora, Silvio, Quaglia, Alberto, Bennicelli, Carlo, Vercelli, Marina

“…Until 100 years ago the epidemiological scenario of human diseases had substantially remained unchanged. The 20th century has been characterized by a fantastic…”
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Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis by De Flora, Silvio, D'Agostini, Francesco, Balansky, Roumen, Camoirano, Anna, Bennicelli, Carlo, Bagnasco, Maria, Cartiglia, Cristina, Tampa, Elena, Longobardi, Maria Grazia, Lubet, Ronald A, Izzotti, Alberto

“…The epidemic of lung cancer and the increase of other tumours and chronic degenerative diseases associated with tobacco smoking have represented one of the…”
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In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens by De Flora, S, Bennicelli, C, Zanacchi, P, Camoirano, A, Morelli, A, De Flora, A

“…N-Acetylcysteine (NAC), reduced (GSH) and oxidized (GSSG) glutathione were negative in the Ames test with 7 Salmonella strains, while L-cysteine was activated…”
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Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke by DE FLORA, Silvio, BALANSKY, Roumen M, D'AGOSTINI, Francesco, IZZOTTI, Alberto, CAMOIRANO, Anna, BENNICELLI, Carlo, ZHONGQIU ZHANG, YIAN WANG, LUBET, Ronald A, MING YOU

“…Mutations and deletions in p53 are the most common genetic lesions in human cancer,and an extraordinarily high incidence of lung cancer occurs in smokers…”
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Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity by DE FLORA, S, CAMOIRANO, A, BAGNASCO, M, BENNICELLI, C, CORBETT, G. E, KERGER, B. D

“…Estimates of the overall reducing capacity of hexavalent chromium(VI) in some human body compartments were made by relating the specific reducing activity of…”
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Modulation of biomarkers by chemopreventive agents in smoke-exposed rats by IZZOTTI, Alberto, BALANSKY, Roumen M, D'AGOSTINI, Francesco, BENNICELLI, Carlo, MYERS, Steven R, GRUBBS, Clinton J, LUBET, Ronald A, KELLOFF, Gary J, DE FLORA, Silvio

“…Chemoprevention opens new perspectives in the prevention of cancer and other chronic degenerative diseases associated with tobacco smoking, exploitable in…”
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Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI) by D'Agostini, Francesco, Izzotti, Alberto, Bennicelli, Carlo, Camoirano, Anna, Tampa, Elena, De Flora, Silvio

“…Several studies have shown that hexavalent chromium [Cr(VI)] induces apoptosis in a variety of in vitro test systems. We instilled intra-tracheally either…”
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Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background by De Flora, S, Cesarone, C F, Balansky, R M, Albini, A, D'Agostini, F, Bennicelli, C, Bagnasco, M, Camoirano, A, Scatolini, L, Rovida, A

“…The thiol N-acetylcysteine (NAC), now under clinical trial for cancer chemoprevention both in Europe (project Euroscan) and in the US (National Cancer…”
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Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice by D'Agostini, F, Balansky, R M, Bennicelli, C, Lubet, R A, Kelloff, G J, De Flora, S

“…In spite of the major role played by cigarette smoking in the epidemiology of lung cancer, it is very difficult to reproduce the carcinogenicity of this…”
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Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test by De Flora, S, Zanacchi, P, Camoirano, A, Bennicelli, C, Badolati, G S

“…Compounds of various chemical classes were comparatively assayed in the Ames reversion test with his- S. typhimurium strains TA1535, TA157 , TA1538, TA98,…”
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Oltipraz chemoprevention trial in Qidong, People's Republic of china: results of urine genotoxicity assays as related to smoking habits by CAMOIRANO, Anna, BAGNASCO, Maria, KENSLER, Thomas W, DE FLORA, Silvio, BENNICELLI, Carlo, CARTIGLIA, Cristina, WANG, Jin-Bing, ZHANG, Bao-Chu, ZHU, Yuan-Rong, QIAN, Geng-Sun, EGNER, Patricia A, JACOBSON, Lisa P

“…A Phase II chemoprevention trial was carried out in Qidong, Jiangsu Province, People's Republic of China. The recruited subjects, all of whom were positive for…”
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Genotoxic effects in bacteria of the light emitted by halogen tungsten lamps having treated quartz bulbs by Camoirano, Anna, Bennicelli, Carlo, Bagnasco, Maria, De Flora, Silvio

“…Traditional halogen tungsten lamps, which are extensively used worldwide for the illumination of indoor environments, have a quartz bulb which transmits not…”
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Oltipraz Chemoprevention Trial in Qidong, People’s Republic of China by Anna Camoirano, Maria Bagnasco, Carlo Bennicelli, Cristina Cartiglia, Jin-Bing Wang, Bao-Chu Zhang, Yuan-Rong Zhu, Geng-Sun Qian, Patricia A. Egner, Lisa P. Jacobson, Thomas W. Kensler, Silvio De Flora

“…A Phase II chemoprevention trial was carried out in Qidong, Jiangsu Province, People’s Republic of China. The recruited subjects, all of whom were positive for…”
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Cytosolic Activation of Aromatic and Heterocyclic Amines. Inhibition by Dicoumarol and Enhancement in Viral Hepatitis B by De Flora, Silvio, Bennicelli, Carlo, D'Agostini, Francesco, Izzotti, Alberto, Camoirano, Anna

“…The aromatic amines 2-aminofluorene (2AF), 2-acetylaminofluorene, and 2-aminoanthracene, and the heterocyclic amines 2-amino-3-methylimidazo[4,5-f]quinoline…”
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Potent genotoxicity of halogen lamps, compared to fluorescent light and sunlight by De Flora, S, Camoirano, A, Izzotti, A, Bennicelli, C

“…The light emitted by halogen lamps induced mutations in Salmonella typhimurium and DNA damage in Escherichia coli, as shown by the hypersensitivity of DNA…”
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Cytosolic Activation of Aromatic and Heterocyclic Amines. Inhibition by Dicoumarol and Enhancement in Viral Hepatitis B by Flora, Silvio De, Bennicelli, Carlo, D'Agostini, Francesco, Izzotti, Alberto, Camoirano, Anna

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