Search Results - "BENNETT, L. H"

The role of the immune system in the generation of neuropathic pain by Calvo, Margarita, PhD, Dawes, John M, PhD, Bennett, David LH, Dr

“…Summary Persistent pain is a sequela of several neurological conditions with a primary immune basis, such as Guillain-Barré syndrome and multiple sclerosis…”
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The mechanisms of microgliosis and pain following peripheral nerve injury by Calvo, Margarita, Bennett, David L.H.

“…Microglia are the resident macrophages in the central nervous system (CNS). Any insult to the CNS homeostasis will induce a rapid change in microglia…”
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Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis by Thakur, Matthew, Rahman, Wahida, Hobbs, Carl, Dickenson, Anthony H, Bennett, David L H

“…Joint degeneration observed in the rat monoiodoacetate (MIA) model of osteoarthritis shares many histological features with the clinical condition. The…”
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Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood by Fricker, Florence R, Lago, Natalia, Balarajah, Sharmili, Tsantoulas, Christoforos, Tanna, Shamil, Zhu, Ning, Fageiry, Samaher K, Jenkins, Mark, Garratt, Alistair N, Birchmeier, Carmen, Bennett, David L H

“…Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the peripheral nervous system, but its importance in adulthood after…”
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Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts by Baskozos, Georgios, Themistocleous, Andreas C, Hebert, Harry L, Pascal, Mathilde M V, John, Jishi, Callaghan, Brian C, Laycock, Helen, Granovsky, Yelena, Crombez, Geert, Yarnitsky, David, Rice, Andrew S C, Smith, Blair H, Bennett, David L H

“…To improve the treatment of painful Diabetic Peripheral Neuropathy (DPN) and associated co-morbidities, a better understanding of the pathophysiology and risk…”
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Relationship between dry eye symptoms and pain sensitivity by Vehof, Jelle, Kozareva, Diana, Hysi, Pirro G, Harris, Juliette, Nessa, Ayrun, Williams, Frances K, Bennett, David L H, McMahon, Steve B, Fahy, Samantha J, Direk, Kenan, Spector, Tim D, Hammond, Christopher J

“…Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and…”
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A Comparison of RNA-Seq and Exon Arrays for Whole Genome Transcription Profiling of the L5 Spinal Nerve Transection Model of Neuropathic Pain in the Rat by Perkins, James R, Antunes-Martins, Ana, Calvo, Margarita, Grist, John, Rust, Werner, Schmid, Ramona, Hildebrandt, Tobias, Kohl, Matthias, Orengo, Christine, McMahon, Stephen B, Bennett, David LH

“…Background: The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing…”
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Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration by Watson-Scales, Sheona, Kalmar, Bernadett, Lana-Elola, Eva, Gibbins, Dorota, La Russa, Federica, Wiseman, Frances, Williamson, Matthew, Saccon, Rachele, Slender, Amy, Olerinyova, Anna, Mahmood, Radma, Nye, Emma, Cater, Heather, Wells, Sara, Yu, Y Eugene, Bennett, David L H, Greensmith, Linda, Fisher, Elizabeth M C, Tybulewicz, Victor L J

“…Down Syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and results in a spectrum of phenotypes including learning and memory deficits, and motor…”
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ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data by Perkins, James R, Dawes, John M, McMahon, Steve B, Bennett, David L H, Orengo, Christine, Kohl, Matthias

“…Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology…”
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Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury by Calvo, Margarita, Richards, Natalie, Schmid, Annina B, Barroso, Alejandro, Zhu, Lan, Ivulic, Dinka, Zhu, Ning, Anwandter, Philipp, Bhat, Manzoor A, Court, Felipe A, McMahon, Stephen B, Bennett, David L H

“…Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over…”
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Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study by Phillips, Tudor J.C., Brown, Matthew, Ramirez, Juan D., Perkins, James, Woldeamanuel, Yohannes W., Williams, Amanda C. de C., Orengo, Christine, Bennett, David L.H., Bodi, Istvan, Cox, Sarah, Maier, Christoph, Krumova, Elena K., Rice, Andrew S.C.

“…Study participants with HIV-associated sensory polyneuropathy (HIV-SN) had higher plasma triglyceride concentrations, depression, anxiety, catastrophizing…”
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Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice by Sisignano, Marco, Angioni, Carlo, Ferreiros, Nerea, Schuh, Claus-Dieter, Suo, Jing, Schreiber, Yannick, Dawes, John M, Antunes-Martins, Ana, Bennett, David L H, McMahon, Stephen B, Geisslinger, Gerd, Scholich, Klaus

“…Peripheral sensitization during inflammatory pain is mediated by a variety of endogenous proalgesic mediators including a number of oxidized lipids, some of…”
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Painful and painless channelopathies by Bennett, David L H, Dr, Woods, C Geoffrey, Prof

“…Summary The discovery of genetic variants that substantially alter an individual's perception of pain has led to a step-change in our understanding of…”
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ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury by Bartus, Katalin, Burnside, Emily R., Galino, Jorge, James, Nicholas D., Bennett, David L. H., Bradbury, Elizabeth J.

“…We recently discovered a novel role for neuregulin‐1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord…”
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Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies by Xu, Min, Bennett, David L H, Querol, Luis Antonio, Wu, Long-Jun, Irani, Sarosh R, Watson, James C, Pittock, Sean J, Klein, Christopher J

“…The immune system has long been recognised important in pain regulation through inflammatory cytokine modulation of peripheral nociceptive fibres. Recently,…”
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New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain by Feldman, Eva L., Nave, Klaus-Armin, Jensen, Troels S., Bennett, David L.H.

“…Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and…”
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Ferri- to ferro-magnetic transition in the martensitic phase of a Heusler alloy by Bennett, L.H., Provenzano, V., Shull, R.D., Levin, I., Della Torre, E., Jin, Y.

“…► Ni50Mn35In15 Heusler alloy exhibits large MCE peaks near room temperature. ► The alloy's magnetic properties have been studied for refrigeration…”
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Potent Analgesic Effects of GDNF in Neuropathic Pain States by Boucher, Timothy J., Okuse, Kenji, David L. H. Bennett, Munson, John B., Wood, John N., McMahon, Stephen B.

“…Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely…”
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Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78 BiP in prostate cancer cells by Bennett, H L, Fleming, J T, O'Prey, J, Ryan, K M, Leung, H Y

“…Pro-survival signalling mediated by the androgen receptor (AR) is implicated as a key contributor to prostate carcinogenesis. As prostate tumours are…”
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α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage by Patel, Ryan, Bauer, Claudia S, Nieto-Rostro, Manuela, Margas, Wojciech, Ferron, Laurent, Chaggar, Kanchan, Crews, Kasumi, Ramirez, Juan D, Bennett, David L H, Schwartz, Arnold, Dickenson, Anthony H, Dolphin, Annette C

“…The α2δ-1 subunit of voltage-gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target of gabapentinoid drugs. It is…”
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