Search Results - "BENNETT, Joel S"

Regulation of integrins in platelets by Bennett, Joel S.

“…ABSTRACT Blood platelets prevent bleeding after trauma by forming occlusive aggregates at sites of vascular injury. Platelet aggregation is mediated by the…”
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Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment by Moore, David T, Nygren, Patrik, Jo, Hyunil, Boesze-Battaglia, Kathleen, Bennett, Joel S, DeGrado, William F

“…Binding of the talin-1 FERM (4.1/ezrin/radixin/moesin) domain to the β3 cytosolic tail causes activation of the integrin αIIbβ3. The FERM domain also binds to…”
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NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation by Metcalf, Douglas G, Moore, David T, Wu, Yibing, Kielec, Joseph M, Molnar, Kathleen, Valentine, Kathleen G, Wand, A. Joshua, Bennett, Joel S, DeGrado, William F

“…The integrin αIIbβ3 is a transmembrane (TM) heterodimeric adhesion receptor that exists in equilibrium between resting and active ligand binding conformations…”
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Consensus motif for integrin transmembrane helix association by Berger, Bryan W, Kulp, Daniel W, Span, Lisa M, DeGrado, Jessica L, Billings, Paul C, Senes, Alessandro, Bennett, Joel S, DeGrado, William F

“…Interactions between transmembrane (TM) helices play an important role in the regulation of diverse biological functions. For example, the TM helices of…”
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Pro-thrombotic State Induced by Post-translational Modification of Fibrinogen by Reactive Nitrogen Species by Vadseth, Caryn, Souza, Jose M., Thomson, Leonor, Seagraves, Amy, Nagaswami, Chandrasekaran, Scheiner, Tomas, Torbet, Jim, Vilaire, Gaston, Bennett, Joel S., Murciano, Juan-Carlos, Muzykantov, Vladimir, Penn, Marc S., Hazen, Stanley L., Weisel, John W., Ischiropoulos, Harry

“…Formation of nitric oxide-derived oxidants has been linked to development of atherosclerosis and associated thrombotic complications. Although systemic levels…”
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Small-molecule inhibitors of integrin α₂β₁ that prevent pathological thrombus formation via an allosteric mechanism by Miller, Meredith W, Basra, Sandeep, Kulp, Daniel W, Billings, Paul C, Choi, Sungwook, Beavers, Mary Pat, McCarty, Owen J.T, Zou, Zhiying, Kahn, Mark L, Bennett, Joel S, DeGrado, William F

“…There is a grave need for safer antiplatelet therapeutics to prevent heart attack and stroke. Agents targeting the interaction of platelets with the diseased…”
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Binding Strength and Activation State of Single Fibrinogen-Integrin Pairs on Living Cells by Litvinov, Rustem I., Shuman, Henry, Bennett, Joel S., Weisel, John W.

“…Integrin activation states determine the ability of these receptors to mediate cell-matrix and cell-cell interactions. The prototypic example of this…”
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Identification of Interacting Hot Spots in the β3 Integrin Stalk Using Comprehensive Interface Design by Donald, Jason E., Zhu, Hua, Litvinov, Rustem I., DeGrado, William F., Bennett, Joel S.

“…Protein-protein interfaces are usually large and complementary surfaces, but specific side chains, representing energetic “hot spots,” often contribute…”
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A Push-Pull Mechanism for Regulating Integrin Function by Li, Wei, Metcalf, Douglas G., Gorelik, Roman, Li, Renhao, Mitra, Neal, Nanda, Vikas, Law, Peter B., Lear, James D., DeGrado, William F., Bennett, Joel S., Wells, James A.

“…Homomeric and heteromeric interactions between the αIIb and β3 transmembrane domains are involved in the regulation of integrin αIIbβ3 function. These domains…”
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Are Antiplatelet Agents Beneficial in Essential Thrombocythemia? Maybe Yes, Probably No by Bennett, Joel S

“…Thrombocytosis, which is frequently encountered in clinical practice, is usually secondary to infection, inflammation, tumor, surgical stress, iron deficiency,…”
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Shedding New Light on the Platelet Storage Lesion by Bennett, Joel S

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NOVEL PLATELET INHIBITORS by Bennett, Joel S

“…Platelet-inhibitory drugs are of proven benefit to individuals who suffer from atherosclerotic cardiovascular disease. Despite substantial effort to identify…”
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The Platelet Integrin αIIbβ3 Differentially Interacts with Fibrin Versus Fibrinogen by Litvinov, Rustem I., Farrell, David H., Weisel, John W., Bennett, Joel S.

“…Fibrinogen binding to the integrin αIIbβ3 mediates platelet aggregation and spreading on fibrinogen-coated surfaces. However, in vivo αIIbβ3 activation and…”
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A little bit of kindlin goes a long way by Bennett, Joel S.

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AJC Editor's Consensus: Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk by Friedewald, Vincent E., MD, Bennett, Joel S., MD, Christo, J. Paul, MD, MBA, Pool, James L., MD, Scheiman, James M., MD, Simon, Lee S., MD, Strand, Vibeke, MD, White, William B., MD, Williams, Gary W., MD, PhD, Roberts, William C., MD

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A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice by Zhou, Junsong, Wu, Yi, Rauova, Lubica, Koma, Gavin, Wang, Lu, Poncz, Mortimer, Li, Hong, Liu, Tong, Fong, Karen P., Bennett, Joel S., Kunapuli, Satya P., Essex, David W.

“…Although several members of protein disulfide isomerase (PDI) family support thrombosis, other PDI family members with the CXYC motif remain uninvestigated…”
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Use of nonsteroidal antiinflammatory drugs : An update for clinicians a scientific statement from the american heart association by ANTMAN, Elliott M, BENNETT, Joel S, DAUGHERTY, Alan, FURBERG, Curt, ROBERTS, Harold, TAUBERT, Kathryn A

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Platelet αIIbβ3 activation: filling in the pieces by Bennett, Joel S.

“…In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting…”
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Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function by Litvinov, Rustem I., Mravic, Marco, Zhu, Hua, Weisel, John W., DeGrado, William F., Bennett, Joel S.

“…Lateral transmembrane (TM) helix–helix interactions between single-span membrane proteins play an important role in the assembly and signaling of many…”
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Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3 by Kononova, Olga, Litvinov, Rustem I, Blokhin, Dmitry S, Klochkov, Vladimir V, Weisel, John W, Bennett, Joel S, Barsegov, Valeri

“…Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the…”
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