Search Results - "BENNETT, Amanda J"

Meeting the demand for crop production: the challenge of yield decline in crops grown in short rotations by Bennett, Amanda J., Bending, Gary D., Chandler, David, Hilton, Sally, Mills, Peter

“…There is a trend world‐wide to grow crops in short rotation or in monoculture, particularly in conventional agriculture. This practice is becoming more…”
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Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors by van de Bunt, Martijn, Manning Fox, Jocelyn E, Dai, Xiaoqing, Barrett, Amy, Grey, Caleb, Li, Lei, Bennett, Amanda J, Johnson, Paul R, Rajotte, Raymond V, Gaulton, Kyle J, Dermitzakis, Emmanouil T, MacDonald, Patrick E, McCarthy, Mark I, Gloyn, Anna L

“…The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription…”
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Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci by Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I

“…Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited…”
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Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development by Sovio, Ulla, Mook-Kanamori, Dennis O, Warrington, Nicole M, Lawrence, Robert, Briollais, Laurent, Palmer, Colin N A, Cecil, Joanne, Sandling, Johanna K, Syvänen, Ann-Christine, Kaakinen, Marika, Beilin, Lawrie J, Millwood, Iona Y, Bennett, Amanda J, Laitinen, Jaana, Pouta, Anneli, Molitor, John, Davey Smith, George, Ben-Shlomo, Yoav, Jaddoe, Vincent W V, Palmer, Lyle J, Pennell, Craig E, Cole, Tim J, McCarthy, Mark I, Järvelin, Marjo-Riitta, Timpson, Nicholas J

“…An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus…”
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Impact of shortened crop rotation of oilseed rape on soil and rhizosphere microbial diversity in relation to yield decline by Hilton, Sally, Bennett, Amanda J, Keane, Gary, Bending, Gary D, Chandler, David, Stobart, Ron, Mills, Peter

“…Oilseed rape (OSR) grown in monoculture shows a decline in yield relative to virgin OSR of up to 25%, but the mechanisms responsible are unknown. A long term…”
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Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth by FREATHY, Rachel M, BENNETT, Amanda J, PERRY, John R. B, POUTA, Anneli, RUOKONEN, Aimo, HYPPÖNEN, Elina, POWER, Chris, ELLIOTT, Paul, STRACHAN, David P, JÄRVELIN, Marjo-Riitta, SMITH, George Davey, MCCARTHY, Mark I, RING, Susan M, FRAYLING, Timothy M, HATTERSLEY, Andrew T, SHIELDS, Beverley, GROVES, Christopher J, TIMPSON, Nicholas J, WEEDON, Michael N, ZEGGINI, Eleftheria, LINDGREN, Cecilia M, LANGO, Hana

“…Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth Rachel M. Freathy 1 , 2 , Amanda J. Bennett 3 , Susan M. Ring 4 , Beverley Shields 2 ,…”
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Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966 by Sovio, Ulla, Bennett, Amanda J, Millwood, Iona Y, Molitor, John, O'Reilly, Paul F, Timpson, Nicholas J, Kaakinen, Marika, Laitinen, Jaana, Haukka, Jari, Pillas, Demetris, Tzoulaki, Ioanna, Molitor, Jassy, Hoggart, Clive, Coin, Lachlan J M, Whittaker, John, Pouta, Anneli, Hartikainen, Anna-Liisa, Freimer, Nelson B, Widen, Elisabeth, Peltonen, Leena, Elliott, Paul, McCarthy, Mark I, Jarvelin, Marjo-Riitta

“…Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants…”
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Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells by Thurner, Matthias, Shenhav, Liraz, Wesolowska-Andersen, Agata, Bennett, Amanda J., Barrett, Amy, Gloyn, Anna L., McCarthy, Mark I., Beer, Nicola L., Efrat, Shimon

“…Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic…”
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Evaluation of common type 2 diabetes risk variants in a South Asian population of Sri Lankan descent by Hassanali, Neelam, De Silva, N Maneka G, Robertson, Neil, Rayner, N William, Barrett, Amy, Bennett, Amanda J, Groves, Christopher J, Matthews, David R, Katulanda, Prasad, Frayling, Timothy M, McCarthy, Mark I

“…Most studies seeking common variant associations with type 2 diabetes (T2D) have focused on individuals of European ancestry. These discoveries need to be…”
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Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation by Althari, Sara, Najmi, Laeya A., Bennett, Amanda J., Aukrust, Ingvild, Rundle, Jana K., Colclough, Kevin, Molnes, Janne, Kaci, Alba, Nawaz, Sameena, van der Lugt, Timme, Hassanali, Neelam, Mahajan, Anubha, Molven, Anders, Ellard, Sian, McCarthy, Mark I., Bjørkhaug, Lise, Njølstad, Pål Rasmus, Gloyn, Anna L.

“…Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A…”
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Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes by Misra, Shivani, Hassanali, Neelam, Bennett, Amanda J, Juszczak, Agata, Caswell, Richard, Colclough, Kevin, Valabhji, Jonathan, Ellard, Sian, Oliver, Nicholas S, Gloyn, Anna L

“…Heterozygous loss-of-function mutations in cause maturity-onset diabetes of the young (MODY). Affected individuals can be treated with low-dose sulfonylureas…”
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Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes by Juszczak, Agata, Pavić, Tamara, Vučković, Frano, Bennett, Amanda J, Shah, Neha, Pape Medvidović, Edita, Groves, Christopher J, Šekerija, Mario, Chandler, Kyla, Burrows, Carla, Rojnić Putarek, Nataša, Vučić Lovrenčić, Marijana, Ćuća Knežević, Jadranka, James, Tim J, Gloyn, Anna L, Lauc, Gordan, McCarthy, Mark I, Owen, Katharine R, Gornik, Olga

“…Maturity-onset diabetes of the young (MODY) due to variants in is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed…”
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Response to Comment on Misra et al. Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes. Diabetes Care 2020;43:909-912 by Misra, Shivani, Hassanali, Neelam, Bennett, Amanda J, Juszczak, Agata, Caswell, Richard, Colclough, Kevin, Valabhji, Jonathan, Ellard, Sian, Oliver, Nicholas S, Gloyn, Anna L

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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight by Boomsma, Dorret I, Smith, George Davey, Power, Chris, Jaddoe, Vincent W V, Jarvelin, Marjo-Riitta, Freathy, Rachel M, Mook-Kanamori, Dennis O, Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J, Berry, Diane J, Warrington, Nicole M, Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A, Bradfield, Jonathan P, Kerkhof, Marjan, Marsh, Julie A, Mägi, Reedik, Chen, Chih-Mei, Lyon, Helen N, Kirin, Mirna, Adair, Linda S, Aulchenko, Yurii S, Bennett, Amanda J, Borja, Judith B, Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan J M, Cousminer, Diana L, de Geus, Eco J C, Deloukas, Panos, Elliott, Paul, Evans, David M, Froguel, Philippe, Glaser, Beate, Groves, Christopher J, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hirschhorn, Joel N, Hofman, Albert, Holly, Jeff M P, Hyppönen, Elina, Kanoni, Stavroula, Knight, Bridget A, Laitinen, Jaana, Lindgren, Cecilia M, McArdle, Wendy L, O'Reilly, Paul F, Pennell, Craig E, Postma, Dirkje S, Pouta, Anneli, Ramasamy, Adaikalavan, Rayner, Nigel W, Ring, Susan M, Rivadeneira, Fernando, Shields, Beverley M, Strachan, David P, Surakka, Ida, Taanila, Anja, Tiesler, Carla, Uitterlinden, Andre G, van Duijn, Cornelia M, Wijga, Alet H, Willemsen, Gonneke, Zhang, Haitao, Zhao, Jianhua, Wilson, James F, Steegers, Eric A P, Hattersley, Andrew T, Eriksson, Johan G, Peltonen, Leena, Mohlke, Karen L, Grant, Struan F A, Hakonarson, Hakon, Koppelman, Gerard H, Dedoussis, George V, Heinrich, Joachim, Gillman, Matthew W, Palmer, Lyle J, Frayling, Timothy M

“…To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from…”
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Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile by THANABALASINGHAM, Gaya, HUFFMAN, Jennifer E, HASSANALI, Neelam, PUCIC, Maja, BENNETT, Amanda J, ESSAFI, Abdelkader, POLASEK, Ozren, MUGHAL, Saima A, REDZIC, Irma, PRIMORAC, Dragan, ZGAGA, Lina, KOLCIC, Ivana, KATTLA, Jayesh J, HANSEN, Torben, GASPERIKOVA, Daniela, TJORA, Erling, STRACHAN, Mark W. J, NIELSEN, Trine, STANIK, Juraj, KLIMES, Iwar, PEDERSEN, Oluf B, NJØLSTAD, Pål R, WILD, Sarah H, NOVOKMET, Mislav, GYLLENSTEN, Ulf, GORNIK, Olga, WILSON, James F, HASTIE, Nicholas D, CAMPBELL, Harry, MCCARTHY, Mark I, RUDD, Pauline M, OWEN, Katharine R, LAUC, Gordan, WRIGHT, Alan F, RUDAN, Igor, GLOYN, Anna L, HAYWARD, Caroline, ADAMCZYK, Barbara, REYNOLDS, Rebecca M, MUZINIC, Ana

“…A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that…”
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Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent: A meta-analysis of 14 cohort studies by Nettleton, Jennifer A, McKeown, Nicola M, Kanoni, Stavroula, Lemaitre, Rozenn N, Hivert, Marie-France, Ngwa, Julius, van Rooij, Frank J.A, Sonestedt, Emily, Wojczynski, Mary K, Ye, Zheng, Tanaka, Tosh

“…OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent…”
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Impact of fresh root material and mature crop residues of oilseed rape (Brassica napus) on microbial communities associated with subsequent oilseed rape by Bennett, Amanda J, Hilton, Sally, Bending, Gary D, Chandler, David, Mills, Peter

“…Glasshouse bioassays were conducted to assess the impact of different inputs of oilseed rape plant material on soil and rhizosphere microbial diversity…”
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Performance of carrot and onion seed primed with beneficial microorganisms in glasshouse and field trials by Bennett, Amanda J., Mead, Andrew, Whipps, John M.

“…Beneficial microorganisms (Clonostachys rosea IK726, Pseudomonas chlororaphis MA342, Pseudomonas fluorescens CHA0, Trichoderma harzianum T22 and Trichoderma…”
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Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis by Kanoni, Stavroula, Nettleton, Jennifer A, Hivert, Marie-France, Ye, Zheng, van Rooij, Frank J A, Shungin, Dmitry, Sonestedt, Emily, Ngwa, Julius S, Wojczynski, Mary K, Lemaitre, Rozenn N, Gustafsson, Stefan, Anderson, Jennifer S, Tanaka, Toshiko, Hindy, George, Saylor, Georgia, Renstrom, Frida, Bennett, Amanda J, van Duijn, Cornelia M, Florez, Jose C, Fox, Caroline S, Hofman, Albert, Hoogeveen, Ron C, Houston, Denise K, Hu, Frank B, Jacques, Paul F, Johansson, Ingegerd, Lind, Lars, Liu, Yongmei, McKeown, Nicola, Ordovas, Jose, Pankow, James S, Sijbrands, Eric J G, Syvänen, Ann-Christine, Uitterlinden, André G, Yannakoulia, Mary, Zillikens, M Carola, Wareham, Nick J, Prokopenko, Inga, Bandinelli, Stefania, ouhi, Nita G, Cupples, L Adrienne, Loos, Ruth J, Hallmans, Goran, Dupuis, Josée, Langenberg, Claudia, Ferrucci, Luigi, Kritchevsky, Stephen B, McCarthy, Mark I, Ingelsson, Erik, Borecki, Ingrid B, Witteman, Jacqueline C M, Orho-Melander, Marju, Siscovick, David S, Meigs, James B, Franks, Paul W, Dedoussis, George V

“…OBJECTIVEMany genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential…”
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Maturity onset diabetes of the young due to HNF1A variants in Croatia by Pavić, Tamara, Juszczak, Agata, Pape Medvidović, Edita, Burrows, Carla, Šekerija, Mario, Bennett, Amanda J, Ćuća Knežević, Jadranka, Gloyn, Anna L, Lauc, Gordan, McCarthy, Mark I, Gornik, Olga, Owen, Katharine R

“…Maturity onset diabetes of the young due to mutations (HNF1A-MODY) is the most frequent form of monogenic diabetes in adults. It is often misdiagnosed as type…”
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