Search Results - "BENEDICTO, Ignacio"

Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization by Pan, Chendong, Banerjee, Kalpita, Lehmann, Guillermo L., Almeida, Dena, Hajjar, Katherine A., Benedicto, Ignacio, Jiang, Zhichun, Radu, Roxana A., Thompson, David H., Rodriguez-Boulan, Enrique, Nociari, Marcelo M.

“…Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that depend on the tissue analyzed. Retinal lipofuscin is unique in…”
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Plasma membrane protein polarity and trafficking in RPE cells: Past, present and future by Lehmann, Guillermo L., Benedicto, Ignacio, Philp, Nancy J., Rodriguez-Boulan, Enrique

“…The retinal pigment epithelium (RPE) comprises a monolayer of polarized pigmented epithelial cells that is strategically interposed between the neural retina…”
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Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models by Benedicto, Ignacio, Dorado, Beatriz, Andrés, Vicente

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates many symptoms of physiological aging and precipitates death. Patients…”
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Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid by Lehmann, Guillermo L, Hanke-Gogokhia, Christin, Hu, Yang, Bareja, Rohan, Salfati, Zelda, Ginsberg, Michael, Nolan, Daniel J, Mendez-Huergo, Santiago P, Dalotto-Moreno, Tomas, Wojcinski, Alexandre, Ochoa, Francisca, Zeng, Shemin, Cerliani, Juan P, Panagis, Lampros, Zager, Patrick J, Mullins, Robert F, Ogura, Shuntaro, Lutty, Gerard A, Bang, Jakyung, Zippin, Jonathan H, Romano, Carmelo, Rabinovich, Gabriel A, Elemento, Olivier, Joyner, Alexandra L, Rafii, Shahin, Rodriguez-Boulan, Enrique, Benedicto, Ignacio

“…The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients…”
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The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells by Perez Bay, Andres E., Schreiner, Ryan, Benedicto, Ignacio, Paz Marzolo, Maria, Banfelder, Jason, Weinstein, Alan M., Rodriguez-Boulan, Enrique J.

“…The basolateral recycling and transcytotic pathways of epithelial cells were previously defined using markers such as transferrin (TfR) and polymeric IgA…”
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Increased Circulating Pro-Inflammatory Cytokines and Th17 Lymphocytes in Hashimoto’s Thyroiditis by Figueroa-Vega, Nicté, Alfonso-Pérez, Manuel, Benedicto, Ignacio, Sánchez-Madrid, Francisco, González-Amaro, Roberto, Marazuela, Mónica

“…Context: Th17 lymphocytes play an important role in different chronic inflammatory and autoimmune conditions. Aim: The aim of the study was to explore the…”
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Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors by Benedicto, Ignacio, Lehmann, Guillermo L., Ginsberg, Michael, Nolan, Daniel J., Bareja, Rohan, Elemento, Olivier, Salfati, Zelda, Alam, Nazia M., Prusky, Glen T., Llanos, Pierre, Rabbany, Sina Y., Maminishkis, Arvydas, Miller, Sheldon S., Rafii, Shahin, Rodriguez-Boulan, Enrique

“…The outer blood-retina barrier is established through the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid…”
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Directional Fluid Transport across Organ-Blood Barriers: Physiology and Cell Biology by Caceres, Paulo S, Benedicto, Ignacio, Lehmann, Guillermo L, Rodriguez-Boulan, Enrique J

“…Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of…”
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Caveolin‐1 deficiency induces a MEK‐ERK1/2‐Snail‐1‐dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis by Strippoli, Raffaele, Loureiro, Jesús, Moreno, Vanessa, Benedicto, Ignacio, Pérez Lozano, María Luisa, Barreiro, Olga, Pellinen, Teijo, Minguet, Susana, Foronda, Miguel, Osteso, Maria Teresa, Calvo, Enrique, Vázquez, Jesús, López Cabrera, Manuel, del Pozo, Miguel Angel

“…Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial–mesenchymal…”
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Clathrin mediates infectious hepatitis C virus particle egress by Benedicto, Ignacio, Gondar, Virgínia, Molina-Jiménez, Francisca, García-Buey, Luisa, López-Cabrera, Manuel, Gastaminza, Pablo, Majano, Pedro L

“…Although it is well established that hepatitis C virus (HCV) entry into hepatocytes depends on clathrin-mediated endocytosis, the possible roles of clathrin in…”
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection by BENEDICTO, Ignacio, MOLINA-JIMENEZ, Francisca, MAJANO, Pedro L, BARTOSCH, Birke, COSSET, François-Loïc, LAVFLLETTE, Dimitri, PRIETO, Jesús, MORENO-OTERO, Ricardo, VALENZUELA-FERNANDEZ, Agustin, ALDABE, Rafael, LOPEZ-CABRERA, Manuel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells by Strippoli, Raffaele, Benedicto, Ignacio, Perez Lozano, Maria Luisa, Pellinen, Teijo, Sandoval, Pilar, Lopez-Cabrera, Manuel, del Pozo, Miguel Angel

“…Peritoneal fibrosis is a frequent complication of peritoneal dialysis following repeated low grade inflammatory and pro-fibrotic insults. This pathological…”
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Coronary and carotid artery dysfunction and KV7 overexpression in a mouse model of Hutchinson-Gilford progeria syndrome by Macías, Álvaro, Nevado, Rosa M., González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María Jesús, Dorado, Beatriz, Benedicto, Ignacio, Andrés, Vicente

“…Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease caused by expression of progerin, a lamin A variant that is also expressed at…”
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Hepatitis C virus envelope components alter localization of hepatocyte tight junction–associated proteins and promote occludin retention in the endoplasmic reticulum by Benedicto, Ignacio, Molina‐Jiménez, Francisca, Barreiro, Olga, Maldonado‐Rodríguez, Alejandra, Prieto, Jesús, Moreno‐Otero, Ricardo, Aldabe, Rafael, López‐Cabrera, Manuel, Majano, Pedro L.

“…Hepatocyte tight junctions (TJ) play key roles in characteristic liver functions, including bile formation and secretion. Infection by hepatitis C virus (HCV)…”
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Basolateral sorting of chloride channel 2 is mediated by interactions between a dileucine motif and the clathrin adaptor AP-1 by de la Fuente-Ortega, Erwin, Gravotta, Diego, Perez Bay, Andres, Benedicto, Ignacio, Carvajal-Gonzalez, Jose Maria, Lehmann, Guillermo L, Lagos, Carlos F, Rodríguez-Boulan, Enrique

“…In spite of the many key cellular functions of chloride channels, the mechanisms that mediate their subcellular localization are largely unknown. ClC-2 is a…”
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Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells by Lehmann, Guillermo L, Ginsberg, Michael, Nolan, Daniel J, Rodríguez, Cristina, Martínez-González, José, Zeng, Shemin, Voigt, Andrew P, Mullins, Robert F, Rafii, Shahin, Rodriguez-Boulan, Enrique, Benedicto, Ignacio

“…Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by…”
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Interplay among cellular polarization,lipoprotein metabolism and hepatitis C virus entry by Benedicto, Ignacio, Molina-Jiménez, Francisca, Moreno-Otero, Ricardo, López-Cabrera, Manuel, Majano, Pedro L

“…Hepatitis C virus （HCV） infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become…”
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Caveolin‐1 deficiency induces a MEK‐ERK1/2‐Snail‐1‐dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis by Strippoli, Raffaele, Loureiro, Jesús, Moreno, Vanessa, Benedicto, Ignacio, Lozano, María Luisa Pérez, Barreiro, Olga, Pellinen, Teijo, Minguet, Susana, Foronda, Miguel, Osteso, Maria Teresa, Calvo, Enrique, Vázquez, Jesús, Cabrera, Manuel López, del Pozo, Miguel Angel

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Expression of pituitary tumor–transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)‐associated liver diseases: Evidence for an HBV X protein–mediated inhibition of PTTG1 ubiquitination and degradation by Molina‐Jiménez, Francisca, Benedicto, Ignacio, Murata, Miki, Martín‐Vílchez, Samuel, Seki, Toshihito, Antonio Pintor‐Toro, José, Tortolero, María, Moreno‐Otero, Ricardo, Okazaki, Kazuichi, Koike, Kazuhiko, Barbero, José Luchi, Matsuzaki, Koichi, Majano, Pedro L., López‐Cabrera, Manuel

“…Chronic infection with hepatitis B virus (HBV) is strongly associated with hepatocellular carcinoma (HCC), and the viral HBx protein plays a crucial role in…”
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Whole Mount Preparation of Mouse Aorta for Confocal Microscopy Studies of the Intima by Barettino, Ana, Benedicto, Ignacio, Andrés, Vicente

“…Confocal imaging of the mouse aorta is a powerful, indispensable technique for the study of cardiovascular pathology ex vivo. Whole mount en face preparations…”
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