Search Results - "BENECKE, Reiner"

Clinical Relevance of Botulinum Toxin Immunogenicity by Benecke, Reiner

“…Botulinum toxin type A is a 150 kD protein produced by Clostridium botulinum , which exists in a complex with up to six additional proteins. The ability of…”
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Swallowing Disturbance Pattern Relates to Brain Lesion Location in Acute Stroke Patients by STEINHAGEN, Volker, GROSSMANN, Annette, BENECKE, Reiner, WALTER, Uwe

“…The relationship of brain lesion location and swallowing disturbance pattern has been poorly studied in acute stroke patients. Sixty patients with first-ever…”
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Pharmacology of therapeutic botulinum toxin preparations by Dressler, Dirk, Benecke, Reiner

“…Therapeutic preparations of botulinum toxin (BT) consist of botulinum neurotoxin (BNT), complexing proteins and excipients. Depending on the target tissue BT…”
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Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial by Volkmann, Jens, Prof, Wolters, Alexander, MD, Kupsch, Andreas, Prof, Müller, Jörg, Prof, Kühn, Andrea A, Prof, Schneider, Gerd-Helge, MD, Poewe, Werner, Prof, Hering, Sascha, MD, Eisner, Wilhelm, Prof, Müller, Jan-Uwe, MD, Deuschl, Günther, Prof, Pinsker, Marcus O, MD, Skogseid, Inger-Marie, MD, Roeste, Geir Ketil, MD, Krause, Martin, Prof, Tronnier, Volker, Prof, Schnitzler, Alfons, Prof, Voges, Jürgen, MD, Nikkhah, Guido, Prof, Vesper, Jan, Prof, Classen, Joseph, Prof, Naumann, Markus, Prof, Benecke, Reiner, Prof

“…Summary Background Severe forms of primary dystonia are difficult to manage medically. We assessed the safety and efficacy of pallidal neurostimulation in…”
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Microstructural white matter changes underlying cognitive and behavioural impairment in ALS--an in vivo study using DTI by Kasper, Elisabeth, Schuster, Christina, Machts, Judith, Kaufmann, Joern, Bittner, Daniel, Vielhaber, Stefan, Benecke, Reiner, Teipel, Stefan, Prudlo, Johannes

“…A relevant fraction of patients with amyotrophic lateral sclerosis (ALS) exhibit a fronto-temporal pattern of cognitive and behavioural disturbances with…”
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Response to Therapeutic Plasma Exchange as a Rescue Treatment in Clinically Isolated Syndromes and Acute Worsening of Multiple Sclerosis: A Retrospective Analysis of 90 Patients by Ehler, Johannes, Koball, Sebastian, Sauer, Martin, Mitzner, Steffen, Hickstein, Heiko, Benecke, Reiner, Zettl, Uwe K

“…Experience with therapeutic plasma exchange (TPE) for acute relapses in clinically isolated syndrome (CIS) or multiple sclerosis (MS) patients has been derived…”
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A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis by Dupuis, Luc, Dengler, Reinhard, Heneka, Michael T, Meyer, Thomas, Zierz, Stephan, Kassubek, Jan, Fischer, Wilhelm, Steiner, Franziska, Lindauer, Eva, Otto, Markus, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Winkler, Andrea S, Bogdahn, Ulrich, Benecke, Reiner, Schrank, Bertold, Wessig, Carsten, Grosskreutz, Julian, Ludolph, Albert C

“…Pioglitazone, an oral anti-diabetic that stimulates the PPAR-gamma transcription factor, increased survival of mice with amyotrophic lateral sclerosis (ALS)…”
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Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis by Schuster, Christina, Kasper, Elisabeth, Dyrba, Martin, Machts, Judith, Bittner, Daniel, Kaufmann, Jörn, Mitchell, Alex J, Benecke, Reiner, Teipel, Stefan, Vielhaber, Stefan, Prudlo, Johannes

“…Abstract Clinical, genetic, and pathological findings suggest a close relationship between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia…”
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Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit by WALTER, Uwe, KNOBLICH, Rupert, STEINHAGEN, Volker, DONAT, Martina, BENECKE, Reiner, KLOTH, Antje

“…To determine independent clinical predictors of stroke-associated pneumonia (SAP) that are available in all patients on day of hospital admission. We studied…”
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Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation by Stefan, Katja, Kunesch, Erwin, Benecke, Reiner, Cohen, Leonardo G., Classen, Joseph

“…Associative stimulation has been shown to enhance excitability in the human motor cortex ( Stefan et al. 2000 ); however, little is known about the underlying…”
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Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease by Busse, Knut, Heilmann, Robert, Kleinschmidt, Sabine, Abu-Mugheisib, Mazen, Höppner, Jacqueline, Wunderlich, Christian, Gemende, Irene, Kaulitz, Lara, Wolters, Alexander, Benecke, Reiner, Walter, Uwe

“…ObjectiveCharacteristic features of Parkinson's disease (PD) are asymmetric parkinsonian motor signs, hyposmia and substantia nigra (SN) hyperechogenicity on…”
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A Temporally Asymmetric Hebbian Rule Governing Plasticity in the Human Motor Cortex by Wolters, Alexander, Sandbrink, Friedhelm, Schlottmann, Antje, Kunesch, Erwin, Stefan, Katja, Cohen, Leonardo G, Benecke, Reiner, Classen, Joseph

“…  1 Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, D-18147 Rostock, Germany;   2 Human Cortical Physiology Section,…”
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White matter pathology in ALS and lower motor neuron ALS variants: a diffusion tensor imaging study using tract-based spatial statistics by Prudlo, Johannes, Bißbort, Charlotte, Glass, Aenne, Grossmann, Annette, Hauenstein, Karlheinz, Benecke, Reiner, Teipel, Stefan J.

“…The aim of this work was to investigate white-matter microstructural changes within and outside the corticospinal tract in classical amyotrophic lateral…”
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Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease by Walter, Uwe, Dressler, Dirk, Wolters, Alexander, Wittstock, Matthias, Benecke, Reiner

“…To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically…”
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Behavioral and structural effects of unilateral intrastriatal injections of botulinum neurotoxin a in the rat model of Parkinson's disease by Antipova, Veronica, Hawlitschka, Alexander, Mix, Eilhard, Schmitt, Oliver, Dräger, Désirée, Benecke, Reiner, Wree, Andreas

“…Botulinum neurotoxin (BoNT) inhibits the release of acetylcholine from presynaptic vesicles through its proteinase activity cleaving the SNARE complex…”
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Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease by Wree, Andreas, Mix, Eilhard, Hawlitschka, Alexander, Antipova, Veronica, Witt, Martin, Schmitt, Oliver, Benecke, Reiner

“…Abstract Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In…”
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Timing-dependent plasticity in human primary somatosensory cortex by Wolters, Alexander, Schmidt, Arne, Schramm, Axel, Zeller, Daniel, Naumann, Markus, Kunesch, Erwin, Benecke, Reiner, Reiners, Karlheinz, Classen, Joseph

“…Animal experiments suggest that cortical sensory representations may be remodelled as a consequence of changing synaptic efficacy by timing-dependent…”
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Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans by Werhahn, Konrad J., Kunesch, Erwin, Noachtar, Soheyl, Benecke, Reiner, Classen, Joseph

“…Blockade of uptake carriers of γ-aminobutyric acid (GABA) has been shown to modulate inhibition in cortical slices of experimental animals, although little is…”
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Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial by Mueller, Joerg, Skogseid, Inger M., Benecke, Reiner, Kupsch, Andreas, Trottenberg, Thomas, Poewe, Werner, Schneider, Gerd H., Eisner, Wilhelm, Wolters, Alexander, Müller, J.U., Deuschl, Günther, Pinsker, Marcus O., Roeste, Geir K., Vollmer-Haase, Juliane, Brentrup, Angela, Krause, Martin, Tronnier, Volker, Schnitzler, Alfons, Voges, Jüergen, Nikkhah, Guido, Vesper, Jan, Naumann, Markus, Volkmann, Jens

“…As part of the first randomized, sham‐timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health‐related…”
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Differential astroglial activation in 6-hydroxydopamine models of Parkinson’s disease by Henning, Jeannette, Strauss, Ulf, Wree, Andreas, Gimsa, Jan, Rolfs, Arndt, Benecke, Reiner, Gimsa, Ulrike

“…In rat models of Parkinson’s disease, injections of 6-hydroxydopamine (6-OHDA) into different areas of the basal ganglia result in dopaminergic…”
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