Search Results - "BENDHEIM, P. E"

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease by Bendheim, Paul E, Poeggeler, Burkhard, Neria, Eyal, Ziv, Vivi, Pappolla, Miguel A, Chain, Daniel G

“…The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is…”
Get full text

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein by BENDHEIM, P. E, BROWN, H. R, RUDELLI, R. D, SCALA, L. J, GOLLER, N. L, WEN, G. Y, KASCSAK, R. J, CASHMAN, N. R, BOLTON, D. C

“…The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical…”
Get full text

Scrapie-Associated Prion Protein Accumulates in Astrocytes During Scrapie Infection by Diedrich, J. F., Bendheim, P. E., Kim, Y. S., Carp, R. I., Haase, A. T.

“…In the course of scrapie, a transmissible spongiform encephalopathy caused by an unconventional agent, a normal cellular protein is converted to an abnormal…”
Get full text

Cellular isoform of the scrapie agent protein participates in lymphocyte activation by Cashman, N R, Loertscher, R, Nalbantoglu, J, Shaw, I, Kascsak, R J, Bolton, D C, Bendheim, P E

“…The scrapie agent protein (Sp33-37 or PrPSc) is the disease-associated isoform of a normal cellular membrane protein (Cp33-37 or PrPC) of unknown function. We…”
Get more information

Molecular location of a species-specific epitope on the hamster scrapie agent protein by Bolton, D.C. (New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY), Seligman, S.J, Bablanian, G, Windsor, D, Scala, L.J, Kim, K.S, Chen, C.M.J, Kascsak, R.J, Bendheim, P.E

“…Scrapie is a transmissible neurodegenerative disease of sheep and goats. An abnormal host protein, Sp33-37, is the major protein component of the scrapie agent…”
Get full text

Copurification of Sp33-37 and Scrapie Agent from Hamster Brain Prior to Detectable Histopathology and Clinical Disease by Bolton, David C, Rudelli, Raoul D, Currie, Julia R, Bendheim, Paul E

“…1 Department of Molecular Biology and 2 Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities,…”
Get full text

Isolation and structural studies of the intact scrapie agent protein by Bolton, D C, Bendheim, P E, Marmorstein, A D, Potempska, A

“…Purification of the scrapie agent by methods using digestion with proteinase K yields a protein product, PrP-27-30, with an apparent mass of 27-30 kDa (D. C…”
Get more information

Purification of scrapie agents: how far have we come? by Bolton, D C, Bendheim, P E

Get more information

Purification and Partial Characterization of the Normal Cellular Homologue of the Scrapie Agent Protein by Bendheim, Paul E., Potempska, Anna, Kascsak, Richard J., Bolton, David C.

“…The scrapie agent protein (Sp33-37) is a degradation-resistant protein that aggregates into fibrils and amyloid plaques. This protein is derived from a normal…”
Get full text

Antibodies to a scrapie prion protein by Bendheim, Paul E, Barry, Ronald A, DeArmond, Stephen J, Stites, Daniel P, Prusiner, Stanley B

“…Scrapie is a slow infection of the nervous system which progresses in the absence of any apparent immune response. The recent development of a large-scale…”
Get full text

A 54-kDa Normal Cellular Protein May Be the Precursor of the Scrapie Agent Protease-Resistant Protein by Bendheim, Paul E., Bolton, David C.

“…Scrapie is the best understood of the transmissible spongiform encephalopathies. These neurologic disorders include the human diseases kuru and…”
Get full text

Antibodies to the scrapie protein decorate prion rods by Barry, RA, McKinley, MP, Bendheim, PE, Lewis, GK, DeArmond, SJ, Prusiner, SB

“…Scrapie is a degenerative, transmissible neurologic disease of sheep and goats which occurs in the absence of any detectable host immune response. Antibodies…”
Get full text

Scrapie and Creutzfeldt--Jakob Disease Prion Proteins Share Physical Properties and Antigenic Determinants by Bendheim, Paul E., Bockman, Jeffrey M., McKinley, Michael P., Kingsbury, David T., Prusiner, Stanley B.

“…Scrapie of sheep and goats as well as Creutzfeldt--Jakob disease (CJD) of humans are neurologic disorders caused by slow infectious pathogens. The novel…”
Get full text

Scrapie agent proteins do not accumulate in grey tremor mice by Bendheim, P.E, Marmorstein, A.D, Potempska, A, Bolton, D.C

“…1 Department of Pathological Neurobiology and 2 Department of Molecular Biology, New York State Institute for Basic Research in Developmental Disabilities,…”
Get full text

Creutzfeldt-Jakob disease prion proteins in human brains by Bockman, J M, Kingsbury, D T, McKinley, M P, Bendheim, P E, Prusiner, S B

“…Creutzfeldt-Jakob disease is caused by a slow infectious pathogen, or prion. We found that purified fractions from the brains of two patients with…”
Get more information

The human spongiform encephalopathies by Bendheim, P E

“…The spongiform encephalopathies are comprised of kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straüssler syndrome. These diseases are compared, and their…”
Get more information

Ataxic hemiparesis by Bendheim, P E

Get full text

Scrapie prions aggregate to form amyloid-like birefringent rods by Prusiner, S B, McKinley, M P, Bowman, K A, Bolton, D C, Bendheim, P E, Groth, D F, Glenner, G G

“…A large scale purification protocol employing zonal rotor centrifugation has been developed for scrapie prions. The extensively purified fractions derived…”
Get more information

A modified host protein model of scrapie by Bolton, D C, Bendheim, P E

“…The scrapie agent is still not completely characterized biochemically and ultrastructurally, but its requirement for a functional protein has been established…”
Get more information

Ataxic hemiparesis from a midbrain mass by Bendheim, P E, Berg, B O

“…A 10-year-old boy with leukemia developed ipsilateral corticospinal and cerebellar signs: the ataxic hemiparesis syndrome. Computed tomography revealed a mass…”
Get more information