Aggressive Spindle Cell Rhabdomyosarcoma in an 11-Month-Old Boxer Dog

Rhabdomyosarcoma (RMS) is a malignant neoplasm derived from mesenchymal tissue with a tendency toward myogenic differentiation associated with the embryogenesis of skeletal muscle. According to the histological features, it can be classified in embryonal, botryoid, alveolar, and pleomorphic, which u...

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Bibliographic Details
Published in:	Journal of Veterinary Medical Science Vol. 72; no. 10; pp. 1363 - 1366
Main Authors:	ROZA, Marcello Rodrigues da, Rivadávio Fernandes Batista de AMORIM, CARNEIRO, Fabiana Pirani, BENATTO, Nara, BARRIVIERA, Mauricio, Márcia Cristina da Costa MIGUEL
Format:	Journal Article
Language:	English
Published:	Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01-10-2010 Japan Science and Technology Agency
Subjects:	Animals Autopsy canine Desmin - analysis Dog Diseases - pathology Dogs Euthanasia Male Maxilla - pathology neoplasms rhabdomyosarcoma Rhabdomyosarcoma, Embryonal - diagnosis Rhabdomyosarcoma, Embryonal - pathology Rhabdomyosarcoma, Embryonal - veterinary sarcoma Skull - pathology spindle cell
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Summary:	Rhabdomyosarcoma (RMS) is a malignant neoplasm derived from mesenchymal tissue with a tendency toward myogenic differentiation associated with the embryogenesis of skeletal muscle. According to the histological features, it can be classified in embryonal, botryoid, alveolar, and pleomorphic, which usually correspond to clinical behavior and prognosis. The spindle cell (SCRMS) variant is a rare subtype of the embryonal RMS and is considered to be less aggressive lesion. The aim of the present paper is to report an unusual case of SCRMS in an 11-month-old male boxer dog diagnosed as extensive SCRMS that affected the frontal region of the skull. Due to the aggressive nature of the lesion and poor clinical prognosis the dog's owners preferred euthanasia as a treatment. A full postmortem examination was carried out. Microscopically, the lesion was composed of a highly cellular proliferation of spindle cells arranged in long and intersecting fascicles. After performing the immunohistochemical studies (HHF-35, smooth muscle actin, desmin and MyoD1), the present case was diagnosed as SCRMS.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0916-7250 1347-7439
DOI:	10.1292/jvms.10-0082