Search Results - "BENAIM, Gustavo"

Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease by Benaim, Gustavo, Paniz-Mondolfi, Alberto

“…Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven…”
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Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi by Benaim, Gustavo, Paniz-Mondolfi, Alberto E, Sordillo, Emilia Mia, Martinez-Sotillo, Nathalia

“…There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite, . In the search for new drugs to treat Chagas…”
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Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis by de Souza, Tatiana Guinancio, Benaim, Gustavo, de Souza, Wanderley, Benchimol, Marlene

“…Trichomonas vaginalis is a protozoan that causes human trichomoniasis, the most common non-viral sexually transmitted infection (STI) affecting approximately…”
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SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes by Gil, Zain, Martinez-Sotillo, Nathalia, Pinto-Martinez, Andrea, Mejias, Fabiola, Martinez, Juan Carlos, Galindo, Ivan, Oldfield, Eric, Benaim, Gustavo

“…Leishmania donovani is the causative agent of visceral leishmaniasis. Annually, 500 million new cases of infection are reported mainly in poor communities,…”
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Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src by Stateva, Silviya R, Salas, Valentina, Anguita, Estefanía, Benaim, Gustavo, Villalobo, Antonio

“…Src family non-receptor tyrosine kinases play a prominent role in multiple cellular processes, including: cell proliferation, differentiation, cell survival,…”
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Editorial: Chagas disease novel drug targets and treatments by Duschak, Vilma G, Paniz Mondolfi, Alberto E, Benaim, Gustavo

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Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option by Sbaraglini, María Laura, Vanrell, María Cristina, Bellera, Carolina Leticia, Benaim, Gustavo, Carrillo, Carolina, Talevi, Alan, Romano, Patricia Silvia

“…Neglected tropical diseases represent a major sanitary problem and a huge economic burden to endemic countries, and are currently expanding to non-endemic…”
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Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis by Martinez-Sotillo, Nathalia, Pinto-Martínez, Andrea, Hejchman, Elżbieta, Benaim, Gustavo

“…Leishmaniasis is a parasitic disease representing an important problem of public health. Visceral leishmaniasis, resulting from infection with Leishmania…”
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Characterization of phospho-(tyrosine)-mimetic calmodulin mutants by Stateva, Silviya R, Salas, Valentina, Benaim, Gustavo, Menéndez, Margarita, Solís, Dolores, Villalobo, Antonio

“…Calmodulin (CaM) phosphorylated at different serine/threonine and tyrosine residues is known to exert differential regulatory effects on a variety of…”
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Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies by Benaim, Gustavo, Paniz-Mondolfi, Alberto E., Ramírez, Juan David, Sordillo, Emilia Mia

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Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives by Gutiérrez, Joyce E, Ramírez, Hegira, Fernandez-Moreira, Esteban, Acosta, María E, Mijares, Michael R, De Sanctis, Juan Bautista, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Labrador-Fagúndez, Liesangerli, Stella, Bruno G, Díaz-Pérez, Luis José, Benaim, Gustavo, Charris, Jaime E

“…A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between…”
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In Vitro Anti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile by BENAIM, Gustavo, HERNANDEZ-RODRIGUEZ, Vanessa, MUJICA-GONZALEZ, Sheira, PLAZA-ROJAS, Lourdes, LI SILVA, May, PARRA-GIMENEZ, Nereida, GARCIA-MARCHAN, Yael, PANIZ-MONDOLFI, Alberto, UZCANGA, Graciela

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Determination of Intracellular Ca2+ Concentration in the Human Pathogens Trypanosomatids Leishmania mexicana and Trypanosoma cruzi by the Use of the Fluorescent Ca2+ Indicator Fura-2 by Rey-Cibati, Andre, Valladares-Delgado, Mariana, Benaim, Gustavo

“…Ca 2+ is an essential signaling messenger in all eukariotic cells, playing a pivotal role in many cellular functions as cell growth control (differentiation,…”
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Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana by SERRANO-MARTIN, Xenon, GARCIA-MARCHAN, Yael, FERNANDEZ, Alexis, RODRIGUEZ, Noris, ROJAS, Hector, VISBAL, Gonzalo, BENAIM, Gustavo

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Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis by SERRANO-MARTIN, Xenón, PAYARES, Gilberto, DE LUCCA, Marisel, MARTINEZ, Juan Carlos, MENDOZA-LEON, Alexis, BENAIM, Gustavo

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Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing by Paniz Mondolfi, Alberto E., MD, MSc, FFTM RCPS (Glasg), Jour, George, MD, Johnson, Matthew, MD, Reidy, Jason, PhD, Cason, Ronald C., MSc, Barkoh, Bedia A., MSc, Benaim, Gustavo, PhD, Singh, Rajesh, PhD, Luthra, Rajyalakshmi, PhD

“…Summary Primary cutaneous carcinosarcoma is a rare biphenotypic neoplasm exhibiting both epithelial and sarcomatous elements. Even though its origin and…”
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Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review by Benaim, B Gustavo, Garcia, Célia R S

“…Ca(2+) has been largely recognized as an essential messenger in all eukaryotes, from mammals to parasites. The disruption of Ca(2+) homeostasis in any cell…”
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The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7) by Pimentel, Adriana A., Felibertt, Pimali, Sojo, Felipe, Colman, Laura, Mayora, Adriana, Silva, May Li, Rojas, Hector, Dipolo, Reinaldo, Suarez, Alírica I., Compagnone, Reinaldo S., Arvelo, Francisco, Galindo-Castro, Ivan, De Sanctis, Juan B., Chirino, Perla, Benaim, Gustavo

“…Purpose In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified…”
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Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca[sup.2+] Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease by Benaim, Gustavo, Paniz-Mondolfi, Alberto

“…Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven…”
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The Activity of the Na+/Ca2+ Exchanger Largely Modulates the Ca2+i Signal Induced by Hypo-Osmotic Stress in Rat Cerebellar Astrocytes. The Effect of Osmolarity on Exchange Activity by Rojas, Héctor, Ramos, Magaly, Benaim, Gustavo, Caputo, Carlo, DiPolo, Reinaldo

“…We recently demonstrated that rat cerebellar Type-1 astrocytes express a very active Na+/Ca2+ exchanger highly colocalized with ryanodine receptors (RyRs),…”
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