Search Results - "BENABDELLAH, Karim"

Failure of ALL recognition by CAR T cells: a review of CD 19-negative relapses after anti-CD 19 CAR-T treatment in B-ALL by Aparicio-Pérez, Clara, Carmona, MDolores, Benabdellah, Karim, Herrera, Concha

“…The use of chimeric antigen receptor (CAR) T lymphocytes in the treatment of refractory or relapsed (R/R) B cell acute lymphoblastic leukemia (B-ALL) has meant…”
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Biased and Unbiased Methods for the Detection of Off-Target Cleavage by CRISPR/Cas9: An Overview by Martin, Francisco, Sánchez-Hernández, Sabina, Gutiérrez-Guerrero, Alejandra, Pinedo-Gomez, Javier, Benabdellah, Karim

“…The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 endonuclease (Cas9) derived from bacterial adaptive immune systems…”
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Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER+ Cancer Cells by Diaz-Ruano, Ana Belén, Martinez-Alarcon, Nuria, Perán, Macarena, Benabdellah, Karim, Garcia-Martinez, María de Los Ángeles, Preda, Ovidiu, Ramirez-Tortosa, César, Gonzalez-Hernandez, Andrea, Marchal, Juan Antonio, Picon-Ruiz, Manuel

“…In general, the risk of being diagnosed with cancer increases with age; however, the development of estrogen-receptor-positive (ER+) cancer types in women are…”
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Characterization of Three New Glutaredoxin Genes in the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis: Putative Role of RiGRX4 and RiGRX5 in Iron Homeostasis by Tamayo, Elisabeth, Benabdellah, Karim, Ferrol, Nuria

“…Glutaredoxins (GRXs) are small ubiquitous oxidoreductases involved in the regulation of the redox state in living cells. In an attempt to identify the full…”
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Externally-Controlled Systems for Immunotherapy: From Bench to Bedside by Tristán-Manzano, María, Justicia-Lirio, Pedro, Maldonado-Pérez, Noelia, Cortijo-Gutiérrez, Marina, Benabdellah, Karim, Martin, Francisco

“…Immunotherapy is a very promising therapeutic approach against cancer that is particularly effective when combined with gene therapy. Immuno-gene therapy…”
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Using Gene Editing Approaches to Fine-Tune the Immune System by Pavlovic, Kristina, Tristán-Manzano, María, Maldonado-Pérez, Noelia, Cortijo-Gutierrez, Marina, Sánchez-Hernández, Sabina, Justicia-Lirio, Pedro, Carmona, M Dolores, Herrera, Concha, Martin, Francisco, Benabdellah, Karim

“…Genome editing technologies not only provide unprecedented opportunities to study basic cellular system functionality but also improve the outcomes of several…”
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High-Density Lipoprotein in Metabolic Disorders and Beyond: An Exciting New World Full of Challenges and Opportunities by Zvintzou, Evangelia, Xepapadaki, Eva, Skroubis, George, Mparnia, Victoria, Giannatou, Katerina, Benabdellah, Karim, Kypreos, Kyriakos E

“…High-density lipoprotein (HDL) is an enigmatic member of the plasma lipid and lipoprotein transport system, best known for its ability to promote the reverse…”
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Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy by Blaya-Cánovas, José L, Griñán-Lisón, Carmen, Blancas, Isabel, Marchal, Juan A, Ramírez-Tortosa, César, López-Tejada, Araceli, Benabdellah, Karim, Cortijo-Gutiérrez, Marina, Cano-Cortés, M Victoria, Graván, Pablo, Navarro-Marchal, Saúl A, Gómez-Morales, Jaime, Delgado-Almenta, Violeta, Calahorra, Jesús, Agudo-Lera, María, Sagarzazu, Amaia, Rodríguez-González, Carlos J, Gallart-Aragón, Tania, Eich, Christina, Sánchez-Martín, Rosario M, Granados-Principal, Sergio

“…Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug…”
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A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells by Benabdellah, Karim, Gutierrez-Guerrero, Alejandra, Cobo, Marién, Muñoz, Pilar, Martín, Francisco

“…Chromatin insulators, such as the chicken β-globin locus control region hypersensitive site 4 (HS4), and scaffold/matrix attachment regions (SARs/MARs) have…”
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The Rhizophagus irregularis Genome Encodes Two CTR Copper Transporters That Mediate Cu Import Into the Cytosol and a CTR-Like Protein Likely Involved in Copper Tolerance by Gómez-Gallego, Tamara, Benabdellah, Karim, Merlos, Miguel A, Jiménez-Jiménez, Ana M, Alcon, Carine, Berthomieu, Pierre, Ferrol, Nuria

“…Arbuscular mycorrhizal fungi increase fitness of their host plants under Cu deficient and toxic conditions. In this study, we have characterized two Cu…”
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CRISPR delivery with extracellular vesicles: Promises and challenges by Berggreen, Anne Højberg, Petersen, Julie Lund, Lin, Lin, Benabdellah, Karim, Luo, Yonglun

“…The CRISPR gene editing tool holds great potential for curing genetic disorders. However, the safe, efficient, and specific delivery of the CRISPR/Cas9…”
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Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma by Maldonado-Pérez, Noelia, Tristán-Manzano, María, Justicia-Lirio, Pedro, Martínez-Planes, Elena, Muñoz, Pilar, Pavlovic, Kristina, Cortijo-Gutiérrez, Marina, Blanco-Benítez, Carlos, Castella, María, Juan, Manel, Wenes, Mathias, Romero, Pedro, Molina-Estévez, Francisco J., Marañón, Concepción, Herrera, Concha, Benabdellah, Karim, Martin, Francisco

“…Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several…”
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Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome by Pavlovic, Kristina, Carmona-Luque, MDolores, Corsi, Giulia I, Maldonado-Pérez, Noelia, Molina-Estevez, Francisco J, Peralbo-Santaella, Esther, Cortijo-Gutiérrez, Marina, Justicia-Lirio, Pedro, Tristán-Manzano, María, Ronco-Díaz, Víctor, Ballesteros-Ribelles, Antonio, Millán-López, Alejandro, Heredia-Velázquez, Paula, Fuster-García, Carla, Cathomen, Toni, Seemann, Stefan E, Gorodkin, Jan, Martin, Francisco, Herrera, Concha, Benabdellah, Karim

“…Chimeric antigen receptor-expressing T cells (CAR T cells) have revolutionized cancer treatment, particularly in B cell malignancies. However, the use of…”
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Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells by Tristán-Manzano, María, Maldonado-Pérez, Noelia, Justicia-Lirio, Pedro, Cortijo-Gutierréz, Marina, Tristán-Ramos, Pablo, Blanco-Benítez, Carlos, Pavlovic, Kristina, Aguilar-González, Araceli, Muñoz, Pilar, Molina-Estevez, Francisco J., Griesche, Valerie, Marchal, Juan Antonio, Heras, Sara R., Benabdellah, Karim, Martin, Francisco

“…Controlling transgene expression through an externally administered inductor is envisioned as a potent strategy to improve safety and efficacy of gene therapy…”
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Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines by Benabdellah, Karim, Cobo, Marién, Muñoz, Pilar, Toscano, Miguel G, Martin, Francisco

“…Lentiviral vectors (LVs) are considered one of the most promising vehicles to efficiently deliver genetic information for basic research and gene therapy…”
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Baboon Envelope Pseudotyped “Nanoblades” Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells by Gutierrez-Guerrero, Alejandra, Abrey Recalde, Maria Jimena, Mangeot, Philippe E., Costa, Caroline, Bernadin, Ornellie, Périan, Séverine, Fusil, Floriane, Froment, Gisèle, Martinez-Turtos, Adriana, Krug, Adrien, Martin, Francisco, Benabdellah, Karim, Ricci, Emiliano P., Giovannozzi, Simone, Gijsbers, Rik, Ayuso, Eduard, Cosset, François-Loïc, Verhoeyen, Els

“…Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into human blood…”
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Genome‐edited adult stem cells: Next‐generation advanced therapy medicinal products by Benabdellah, Karim, Sánchez‐Hernández, Sabina, Aguilar‐González, Araceli, Maldonado‐Pérez, Noelia, Gutierrez‐Guerrero, Alejandra, Cortijo‐Gutierrez, Marina, Ramos‐Hernández, Iris, Tristán‐Manzano, María, Galindo‐Moreno, Pablo, Herrera, Concha, Martin, Francisco

“…Over recent decades, gene therapy, which has enabled the treatment of several incurable diseases, has undergone a veritable revolution. Cell therapy has also…”
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Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis by Cobo, Marién, Anderson, Per, Benabdellah, Karim, Toscano, Miguel G, Muñoz, Pilar, García-Pérez, Angélica, Gutierrez, Iván, Delgado, Mario, Martin, Francisco

“…Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS)…”
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Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS2 Protein Docks by Cortijo-Gutiérrez, Marina, Sánchez-Hernández, Sabina, Tristán-Manzano, María, Maldonado-Pérez, Noelia, Lopez-Onieva, Lourdes, Real, Pedro J., Herrera, Concha, Marchal, Juan Antonio, Martin, Francisco, Benabdellah, Karim

“…Integration-deficient lentiviral vectors (IDLVs) have recently generated increasing interest, not only as a tool for transient gene delivery, but also as a…”
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Physiological lentiviral vectors for the generation of improved CAR-T cells by Tristán-Manzano, María, Maldonado-Pérez, Noelia, Justicia-Lirio, Pedro, Muñoz, Pilar, Cortijo-Gutiérrez, Marina, Pavlovic, Kristina, Jiménez-Moreno, Rosario, Nogueras, Sonia, Carmona, M. Dolores, Sánchez-Hernández, Sabina, Aguilar-González, Araceli, Castella, María, Juan, Manel, Marañón, Concepción, Marchal, Juan Antonio, Benabdellah, Karim, Herrera, Concha, Martin, Francisco

“…Anti-CD19 chimeric antigen receptor (CAR)-T cells have achieved impressive outcomes for the treatment of relapsed and refractory B-lineage neoplasms. However,…”
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