Search Results - "BELYK, M"

Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts by Xiang, Bangping, Belyk, Kevin M., Reamer, Robert A., Yasuda, Nobuyoshi

“…We report the discovery of novel N,N′‐disubstituted cinchona alkaloids as efficient phase‐transfer catalysts for the assembly of stereogenic quaternary…”
Get full text

Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts by Lexa, Katrina W, Belyk, Kevin M, Henle, Jeremy, Xiang, Bangping, Sheridan, Robert P, Denmark, Scott E, Ruck, Rebecca T, Sherer, Edward C

“…Molecular design benefits from a strong partnership between chemical intuition and machine learning. Given the proliferation of machine learning in the small…”
Get full text

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization by McLaughlin, Mark, Kong, Jongrock, Belyk, Kevin M, Chen, Billy, Gibson, Andrew W, Keen, Stephen P, Lieberman, David R, Milczek, Erika M, Moore, Jeffrey C, Murray, David, Peng, Feng, Qi, Ji, Reamer, Robert A, Song, Zhiguo J, Tan, Lushi, Wang, Lin, Williams, Michael J

“…An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features of stereocontrol include construction of the fully substituted…”
Get full text

A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions by Ji, Yining, Li, Hongming, Hyde, Alan M, Chen, Qinghao, Belyk, Kevin M, Lexa, Katrina W, Yin, Jingjun, Sherer, Edward C, Williamson, R Thomas, Brunskill, Andrew, Ren, Sumei, Campeau, Louis-Charles, Davies, Ian W, Ruck, Rebecca T

“…Significant catalyst loading reduction and increased reaction robustness have been achieved for a Pd-catalyzed asymmetric intramolecular C-N coupling through…”
Get full text

Motor sequence learning in children with recovered and persistent developmental stuttering: preliminary findings by Tendera, A., Wells, R., Belyk, M., Varyvoda, D., Boliek, C.A., Beal, D.S.

“…•Motor sequence learning was evaluated using performance, recognition, and recall metrics in children with persistent developmental stuttering, children who…”
Get full text

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester by Belyk, Kevin M, Xiang, Bangping, Bulger, Paul G, Leonard, William R, Balsells, Jaume, Yin, Jingjun, Chen, Cheng-yi

“…A concise asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester, a key intermediate in the preparation of many hepatitis C…”
Get full text

Decrease in Driveline Infections With Change in Driveline Management Protocol by Aslam, S, McCann, P, Belyk, M, Topik, A, Torriani, F, Taplitz, R, Silva-Encisco, J, Barnard, D, Greenberg, B, Copeland, J, Pretorius, V, Adler, E

Get full text

Enantioselective Synthesis of N‑Benzylic Heterocycles by Ni/Photoredox Dual Catalysis by Lacker, Caitlin R., DeLano, Travis J., Chen, Emily P., Kong, Jongrock, Belyk, Kevin M., Piou, Tiffany, Reisman, Sarah E.

“…An asymmetric cross-coupling of α-N-heterocyclic trifluoroborates with aryl bromides using Ni/photoredox dual catalysis has been developed. This…”
Get full text

Enantio- and Diastereoselective Total Synthesis of Belzutifan Enabled by Rh-Catalyzed Hydrogenation by Le, Diane N., Johnson, Heather C., Lam, Yu-hong, Sun, Chunrui, Cheng, Lili, Belyk, Kevin M.

“…Herein, we report a nine-step synthesis of belzutifan enabled by a novel Rh-catalyzed asymmetric hydrogenation to install the contiguous fluorinated…”
Get full text

Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides by Li, Hongming, Belyk, Kevin M, Yin, Jingjun, Chen, Qinghao, Hyde, Alan, Ji, Yining, Oliver, Steven, Tudge, Matthew T, Campeau, Louis-Charles, Campos, Kevin R

“…A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method…”
Get full text

Late‐Stage Modification of Oligopeptides by Nickel‐Catalyzed Stereoselective Radical Addition to Dehydroalanine by Qi, Xiaoxu, Jambu, Subramanian, Ji, Yining, Belyk, Kevin M., Panigrahi, Nihar R., Arora, Paramjit S., Strotman, Neil A., Diao, Tianning

“…Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to access non‐canonical peptide analogues for drug discovery. Prior studies…”
Get full text

Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts by Xiang, Bangping, Belyk, Kevin M., Reamer, Robert A., Yasuda, Nobuyoshi

“…We report the discovery of novel N,N′‐disubstituted cinchona alkaloids as efficient phase‐transfer catalysts for the assembly of stereogenic quaternary…”
Get full text

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib by Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M

“…Process development of the synthesis of the orally active poly(ADP-ribose)polymerase inhibitor niraparib is described. Two new asymmetric routes are reported,…”
Get full text

Late‐Stage Modification of Oligopeptides by Nickel‐Catalyzed Stereoselective Radical Addition to Dehydroalanine by Qi, Xiaoxu, Jambu, Subramanian, Ji, Yining, Belyk, Kevin M., Panigrahi, Nihar R., Arora, Paramjit S., Strotman, Neil A., Diao, Tianning

“…Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to access non‐canonical peptide analogues for drug discovery. Prior studies…”
Get full text

Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle by Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M

“…Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including…”
Get full text

Synthesis of α-Hydroxyacetophenones by McLaughlin, Mark, Belyk, Kevin M, Qian, Gang, Reamer, Robert A, Chen, Cheng-yi

“…A general method for the preparation of α-hydroxyacetophenones is presented. Functionalized arylmagnesium species are transmetalated to the corresponding…”
Get full text

Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium by Humphrey, Guy R, Pye, Philip J, Zhong, Yong-Li, Angelaud, Remy, Askin, David, Belyk, Kevin M, Maligres, Peter E, Mancheno, Danny E, Miller, Ross A, Reamer, Robert A, Weissman, Steven A

“…A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key,…”
Get full text

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain by Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc D, Fung, Selena, Lanza, Thomas J, Chang, Linda, Bakshi, Raman K, Dellureficio, James P, Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M, Krska, Shane W, Makarewicz, Amanda K, Martel, Elliot J, Leone, Joseph F, Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L, Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P, Shiao, Lin-Lin, Sullivan, Kathleen M, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S, DeVita, Robert J

“…We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening…”
Get full text

Practical Synthesis of 1,6-Anhydro-2,4-dideoxy-β-d-glycero- hexopyranos-3-ulose from Levoglucosan by Belyk, Kevin M, Leonard, William R, Bender, Dean R, Hughes, David L

Get full text

(783) - INR Remote Monitoring is Associated with Improved Time in Therapeutic Range Following Left Ventricular Assist Device Implantation by Nguyen, V.N., Smith, M., Belyk, M., Brambatti, M., Braun, O.O., Adler, E.D., G, V., Mariski, M., Stevens, C., Feist, A.

Get full text