Search Results - "BELLIZZI, D"

The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern by Bellizzi, Dina, D'Aquila, Patrizia, Scafone, Teresa, Giordano, Marco, Riso, Vincenzo, Riccio, Andrea, Passarino, Giuseppe

“…DNA methylation is a common epigenetic modification of the mammalian genome. Conflicting data regarding the possible presence of methylated cytosines within…”
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SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH by Pellegrini, L, Pucci, B, Villanova, L, Marino, M L, Marfe, G, Sansone, L, Vernucci, E, Bellizzi, D, Reali, V, Fini, M, Russo, M A, Tafani, M

“…Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and…”
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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly by Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, A.I, De Benedictis, G

“…The human sirtuin 3 ( SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of…”
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miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth by Fulciniti, M, Amodio, N, Bandi, R L, Cagnetta, A, Samur, M K, Acharya, C, Prabhala, R, D'Aquila, P, Bellizzi, D, Passarino, G, Adamia, S, Neri, A, Hunter, Z R, Treon, S P, Anderson, K C, Tassone, P, Munshi, N C

“…Deregulated microRNA (miR)/transcription factor (TF)-based networks represent a hallmark of cancer. We report here a novel c-Myc/miR-23b/Sp1 feed-forward loop…”
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Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13 by Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Di Cianni, F., Passarino, G., Rose, G., De Benedictis, G.

“…The human SIRT3 gene contains an intronic VNTR enhancer whose variability is correlated with life span. The SIRT3 5′ flanking region encompasses the PSMD13…”
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Mitochondrial DNA Variability Modulates mRNA and Intra-Mitochondrial Protein Levels of HSP60 and HSP75: Experimental Evidence from Cybrid Lines by Bellizzi, D., Taverna, D., D'Aquila, P., De Blasi, S., De Benedictis, G.

“…To explore possible relationships between mitochondrial DNA (mtDNA) polymorphism and the expression levels of stress-responder nuclear genes we assembled five…”
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Evidence that the mouse insulin receptor substrate-1 belongs to the gene family on which the promoter is activated by estrogen receptor α through its interaction with Sp1 by Panno, M L, Mauro, L, Marsico, S, Bellizzi, D, Rizza, P, Morelli, C, Salerno, M, Giordano, F, Ando’, S

“…In the present study, the molecular mechanism underlying the up-regulatory effect of estradiol (E2) on mouse insulin receptor substrate-1 (IRS-1) promoter was…”
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The allele (A)-110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women by ALTOMARE, K, GRECO, V, PASSARINO, G, FRANCESCHI, C, DE BENEDICTIS, G, BELLIZZI, D, BERARDELLI, M, DATO, S, DERANGO, F, GARASTO, S, ROSE, G, FERACO, E, MARI, V

“…Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with…”
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Heterogeneity of Primer Extension Products in Asymmetric PCR is Due Both to Cleavage by a Structure-Specific Exo/Endonuclease Activity of DNA Polymerases and to Premature Stops by Tombline, Gregory, Bellizzi, Dina, Sgaramella, Vittorio

“…In PCR, DNA polymerases from thermophilic bacteria catalyze the extension of primers annealed to templates as well as the structure-specific cleavage of the…”
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The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene): A relative risk approach by Tan, Qihua, Bellizzi, D, Rose, G, Garasto, S, Franceschi, C, Kruse, T, Vaupel, J.W, De Benedictis, G, Yashin, A.I

“…A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from…”
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Triplet repeats, over-expanded in neuromuscular diseases, are under-represented in mammalian DNA: a survey of models by Astolfi, P, Bellizzi, D, Losso, M A, Sgaramella, V

“…Simple tandem repeats represent more than 1% of the human genome: occasionally they exhibit intergenerational expansibility and are associated with…”
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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages by Bellizzi, Dina, Rose, Giuseppina, Cavalcante, Paola, Covello, Giuseppina, Dato, Serena, De Rango, Francesco, Greco, Valentina, Maggiolini, Marcello, Feraco, Emidio, Mari, Vincenzo, Franceschi, Claudio, Passarino, Giuseppe, De Benedictis, Giovanna

“…SIR2 genes control life span in model organisms, playing a central role in evolutionarily conserved pathways of aging and longevity. We wanted to verify…”
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Association of the mitochondrial DNA haplogroup J with longevity is population specific by DATO, Serena, PASSARINO, Giuseppe, ROSE, Giuseppina, ALTOMARE, Katia, BELLIZZI, Dina, MARI, Vincenzo, FERACO, Emidio, FRANCESCHI, Claudio, DE BENEDICTIS, Giovanna

“…Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been…”
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Frequency and coverage of trinucleotide repeats in eukaryotes by Astolfi, Paola, Bellizzi, Dina, Sgaramella, Vittorio

“…In the aim to assess whether the tri-repeat shortage reported in vertebrates affects specific motifs, such as those causing neuromuscular diseases in man, we…”
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Estradiol Increases IRS-1 Gene Expression and Insulin Signaling in Breast Cancer Cells by Mauro, Loredana, Salerno, Michele, Panno, Maria Luisa, Bellizzi, Dina, Sisci, Diego, Miglietta, Antonella, Surmacz, Eva, Andò, Sebastiano

“…This study demonstrates how the potentiating effects of E2 on insulin signaling in endoplasmic reticulum-positive breast cancer cells are consequent to an…”
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Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity by Marini, Marina, Lapalombella, Rosa, Canaider, Silvia, Farina, Antonio, Monti, Daniela, De Vescovi, Valentina, Morellini, Marina, Bellizzi, Dina, Dato, Serena, De Benedictis, Giovanna, Passarino, Giuseppe, Moresi, Raffaella, Tesei, Silvia, Franceschi, Claudio

“…‘Successful aging’, i.e. the ability to attain old age in relatively good health, is believed to be related to the capability to cope with different…”
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The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women by Altomare, K, Greco, V, Bellizzi, D, Berardelli, M, Dato, S, DeRango, F, Garasto, S, Rose, G, Feraco, E, Mari, V, Passarino, G, Franceschi, C, De Benedictis, G

“…Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with…”
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The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene) by Tan, Qihua, Bellizzi, D, Rose, G, Garasto, S, Franceschi, C, Kruse, T, Vaupel, J.W, De Benedictis, G, Yashin, A.I

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A model for the involvement of Okazaki fragments maturation in the expansion of short tandem repeats by Bellizzi, D, Losso, M A, Sgaramella, V

“…We propose a model for the expansion of short tandem repeats (ESTR), a phenomenon which has been found to occur in human DNA and is associated with a dozen of…”
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The allele (A) sub( -110 ) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women by Altomare, K, Greco, V, Bellizzi, D, Berardelli, M, Dato, S, DeRango, F, Garasto, S, Rose, G, Feraco, E, Mari, V, Passarino, G, Franceschi, C, De Benedictis, G

“…Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with…”
Get full text