Search Results - "BELLINGER, D. A."

Molecular Characterization of Cat Factor XII Gene and Identification of a Mutation Causing Factor XII Deficiency in a Domestic Shorthair Cat Colony by Bender, D. E., Kloos, M. T., Pontius, J. U., Hinsdale, M. E., Bellinger, D. A.

“…Coagulation factor XII (FXII) may be important in cardiovascular and inflammatory diseases. We have identified and characterized a naturally occurring mutation…”
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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia by MONAHAN, P. E, SAMULSKI, R. J, TAZELAAR, J, XIAO, X, NICHOLS, T. C, BELLINGER, D. A, READ, M. S, WALSH, C. E

“…A recombinant adeno-associated virus (rAAV) vector carrying the human factor IX cDNA was tested for safety and therapeutic gene expression in a canine model of…”
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Persistent expression of canine factor IX in hemophilia B canines by CHAO, H, SAMULSKI, R. J, BELLINGER, D. A, MONAHAN, P. E, NICHOLS, T. C, WALSH, C. E

“…We previously demonstrated that direct intramuscular injection of recombinant adeno-associated virus (rAAV) carrying the human FIX (hFIX) cDNA can safely be…”
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Intravenous administration of an AAV-2 vector for the expression of factor IX in mice and a dog model of hemophilia B by HARDING, T. C, KOPRIVNIKAR, K. E, NICHOLS, T. C, BELLINGER, D. A, YENDLURI, S, WAUGH, J, MCARTHUR, J, VERES, G, DONAHUE, B. A, TU, G. H, ZAYEK, N, LEW, S, SUBRAMANIAN, A, SIVAKUMARAN, A, FREY, D, HO, K, VANROEY, M. J

“…Previous experiments have demonstrated the stable expression of factor IX (FIX) protein in mice and canine models of hemophilia B following portal vein gene…”
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Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs by Fang, B, Wang, H, Gordon, G, Bellinger, D A, Read, M S, Brinkhous, K M, Woo, S L, Eisensmith, R C

“…Two recombinant adenoviruses expressing either human alpha 1-antitrypsin (hAAT) or canine factor IX (cFIX) were modified so that they also contained a…”
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In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction in Factor IX-Deficient Dogs by Kay, Mark A., Rothenberg, Steven, Landen, Charles N., Bellinger, Dwight A., Leland, Frances, Toman, Carol, Finegold, Milton, Thompson, Arthur R., Read, M. S., Brinkhous, Kenneth M., Savio L. C. Woo

“…The liver represents a model organ for gene therapy. A method has been developed for hepatic gene transfer in vivo by the direct infusion of recombinant…”
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An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs by Maile, L.A, Busby, W.H, Xi, G, Gollahan, K.P, Flowers, W, Gafbacik, N, Gafbacik, S, Stewart, K, Merricks, E.P, Nichols, T.C, Bellinger, D.A, Clemmons, D.R

“…Abstract Background and aims Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (…”
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Intratracheal administration of recombinant human factor IX (BeneFix) achieves therapeutic levels in hemophilia B dogs by Russell, K E, Read, M S, Bellinger, D A, Leitermann, K, Rup, B J, McCarthy, K P, Keith, Jr, J C, Khor, S P, Schaub, R G, Nichols, T C

“…The purpose of this paper was to establish proof of concept for administration of human recombinant F.IX (rF.IX) by inhalation for therapy of hemophilia B. The…”
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Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression by Fang, B, Eisensmith, R C, Wang, H, Kay, M A, Cross, R E, Landen, C N, Gordon, G, Bellinger, D A, Read, M S, Hu, P C

“…Hemophilia B is caused by a deficiency of blood clotting factor IX (FIX). Previous studies have shown that the delivery of a recombinant adenoviral vector…”
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Preservation of Hemostatic and Structural Properties of Rehydrated Lyophilized Platelets: Potential for Long-Term Storage of Dried Platelets for Transfusion by Read, Marjorie S., Reddick, Robert L., Bode, Arthur P., Bellinger, Dwight A., Nichols, Timothy C., Taylor, Kathryn, Smith, Scott V., McMahon, Debra K., Giggs, Thomas R., Brinkhous, Kenneth M.

“…Currently, therapeutic platelet concentrates can be stored for only 5 days. We have developed a procedure that permits long-term storage of fixed and…”
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Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency by Nichols, Timothy C, Dillow, Aaron M, Franck, Helen W.G, Merricks, Elizabeth P, Raymer, Robin A, Bellinger, Dwight A, Arruda, Valder R, High, Katherine A

“…Dogs with hemophilia A, hemophilia B, von Willebrand disease (VWD), and factor VII deficiency faithfully recapitulate the severe bleeding phenotype that occurs…”
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Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B by NICHOLS, T. C., RAYMER, R. A., FRANCK, H. W. G., MERRICKS, E. P., BELLINGER, D. A., DeFRIESS, N., MARGARITIS, P., ARRUDA, V. R., KAY, M. A., HIGH, K. A.

“…Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe…”
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Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras by Nichols, T C, Samama, C M, Bellinger, D A, Roussi, J, Reddick, R L, Bonneau, M, Read, M S, Bailliart, O, Koch, G G, Vaiman, M

“…von Willebrand factor (vWF) is essential for the induction of occlusive thrombosis in stenosed and injured pig arteries and for normal hemostasis. To separate…”
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Familial and diet-induced hypercholesterolemia in swine : lipid, apoB, ApoA-I concentrations and distributions in plasma and lipoprotein subfractions by HASLER-RAPACZ, J. O, NICHOLS, T. C, GRIGGS, T. R, BELLINGER, D. A, RAPACZ, J

“…Low levels of high-density lipoproteins (HDLs) may constitute an independent risk factor that may be as important as elevated low-density lipoproteins (LDLs)…”
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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector by High, Katherine A, Herzog, Roland W, Yang, Edmund Y, Couto, Linda B, Hagstrom, J. Nathan, Elwell, Dan, Fields, Paul A, Burton, Melissa, Bellinger, Dwight A, Read, Marjorie S, Brinkhous, Kenneth M, Podsakoff, Gregory M, Nichols, Timothy C, Kurtzman, Gary J

“…Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for…”
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Swine models of type 2 diabetes mellitus: Insulin resistance, glucose tolerance, and cardiovascular complications by Bellinger, D.A, Merricks, E.P, Nichols, T.C

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Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors by Kay, Mark A, Snyder, Richard O, Miao, Carol, Meuse, Leonard, Tubb, Julie, Donahue, Brian A, Lin, Hui-Feng, Stafford, Darrel W, Patel, Salil, Thompson, Arthur R, Nichols, Timothy, Read, Marjorie S, Bellinger, Dwight A, Brinkhous, Kenneth M

“…Hemophilia B, or factor IX deficiency, is an X-linked recessive disorder occurring in about 1 in 25,000 males. Affected individuals are at risk for spontaneous…”
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Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs by Brodala, Nadine, Merricks, Elizabeth P, Bellinger, Dwight A, Damrongsri, Damrong, Offenbacher, Steven, Beck, James, Madianos, Phoebus, Sotres, Daniela, Chang, Yu-Ling, Koch, Gary, Nichols, Timothy C

“…OBJECTIVES—The aim of this study was to determine whether recurrent intravenous injections with Porphyromonas gingivalis (P gingivalis), mimicking…”
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Oral Contraceptives and Hormone Replacement Therapy Do Not Increase the Incidence of Arterial Thrombosis in a Nonhuman Primate Model by Bellinger, Dwight A, Williams, J. Koudy, Adams, Michael R, Honore, Erika K, Bender, Diane E

“…Older oral contraceptive (OC) formulations containing high doses of potent synthetic estrogens and progestins are associated with increased risk of thrombosis…”
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Sustained Expression of Therapeutic Level of Factor IX in Hemophilia B Dogs by AAV-Mediated Gene Therapy in Liver by Wang, Lili, Nichols, Timothy C., Read, Marjorie S., Bellinger, Dwight A., Verma, Inder M.

“…We demonstrate that a single intraportal vein injection of a recombinant adeno-associated virus (rAAV) vector encoding canine factor IX (cFIX) cDNA under the…”
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