Search Results - "BEGUINOT, F"

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population? by Valentino, R., D’Esposito, V., Ariemma, F., Cimmino, I., Beguinot, F., Formisano, P.

“…In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on…”
Get full text

Molecular basis of ageing in chronic metabolic diseases by Spinelli, R., Parrillo, L., Longo, M., Florese, P., Desiderio, A., Zatterale, F., Miele, C., Raciti, G. Alexander, Beguinot, F.

“…Aim Over the last decades, the shift in age distribution towards older ages and the progressive ageing which has occurred in most populations have been…”
Get full text

Tribbles homologue 3 (TRIB3) and the insulin-resistance genes in type 2 diabetes by Beguinot, F

Get full text

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E by Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Beguinot, F., Van Obberghen, E.

“…Aims/hypothesis Chronic hyperglycaemia aggravates insulin resistance, at least in part, by increasing the formation of advanced glycation end-products (AGEs)…”
Get full text

Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro by D’Esposito, V., Passaretti, F., Hammarstedt, A., Liguoro, D., Terracciano, D., Molea, G., Canta, L., Miele, C., Smith, U., Beguinot, F., Formisano, P.

“…Aims/hypothesis Type 2 diabetes and obesity are associated with increased risk of site-specific cancers. We have investigated whether metabolic alterations at…”
Get full text

White cell and platelet content affects the release of bioactive factors in different blood-derived scaffolds by Cabaro, S., D'Esposito, V., Gasparro, R., Borriello, F., Granata, F., Mosca, G., Passaretti, F., Sammartino, J. C., Beguinot, F., Sammartino, G., Formisano, P., Riccitiello, F.

“…Platelet-derived factors are biomaterials that might accelerate healing process in oral, maxillofacial, and several other applications. Release of specific…”
Get full text

Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet by Parrillo, L, Costa, V, Raciti, G A, Longo, M, Spinelli, R, Esposito, R, Nigro, C, Vastolo, V, Desiderio, A, Zatterale, F, Ciccodicola, A, Formisano, P, Miele, C, Beguinot, F

“…Background/Objectives: The genomic bases of the adipose tissue abnormalities induced by chronic positive calorie excess have been only partially elucidated. We…”
Get full text

Growth-promoting action and growth factor release by different platelet derivatives by Passaretti, F., Tia, M., D'Esposito, V., Pascale, M. De, Corso, M. Del, Sepulveres, R., Liguoro, D., Valentino, R., Beguinot, F., Formisano, P., Sammartino, G.

“…Abstract Platelet derivatives are commonly used in wound healing and tissue regeneration. Different procedures of platelet preparation may differentially…”
Get full text

PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms by Aprile, M., Ambrosio, M. R., D'Esposito, V., Beguinot, F., Formisano, P., Costa, V., Ciccodicola, A.

“…The nuclear receptor PPARγ is a key regulator of adipogenesis, and alterations of its function are associated with different pathological processes related to…”
Get full text

New expectations from the well-known medicinal properties of Arctium lappa by Miele, C., Beguinot, F.

“…AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has…”
Get full text

Epigenetics: spotlight on type 2 diabetes and obesity by Desiderio, A., Spinelli, R., Ciccarelli, M., Nigro, C., Miele, C., Beguinot, F., Raciti, G. A.

“…Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the…”
Get full text

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance by Andreozzi, F., Procopio, C., Greco, A., Mannino, G. C., Miele, C., Raciti, G. A., Iadicicco, C., Beguinot, F., Pontiroli, A. E., Hribal, M. L., Folli, F., Sesti, G.

“…Aims/hypothesis We determined the contribution to insulin resistance of the PH domain leucine-rich repeat protein phosphatase (PHLPP), which dephosphorylates…”
Get full text

ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity by Ulianich, L., Terrazzano, G., Annunziatella, M., Ruggiero, G., Beguinot, F., Di Jeso, B.

“…We recently reported that, in thyroid cells, ER stress triggered by thapsigargin or tunicamycin, two well known ER stressing agents, induced dedifferentiation…”
Get full text

PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation by Iovino, S, Oriente, F, Botta, G, Cabaro, S, Iovane, V, Paciello, O, Viggiano, D, Perruolo, G, Formisano, P, Beguinot, F

“…TGF-beta1 has been shown to induce autophagy in certain cells but whether and how this action is exerted in muscle and whether this activity relates to…”
Get full text

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway by Lombardi, A., Ulianich, L., Treglia, A. S., Nigro, C., Parrillo, L., Lofrumento, D. D., Nicolardi, G., Garbi, C., Beguinot, F., Miele, C., Di Jeso, B.

“…Aims/hypothesis Beta cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (decline of glucose-stimulated insulin…”
Get full text

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells by Raciti, G. A, Iadicicco, C, Ulianich, L, Vind, B. F, Gaster, M, Andreozzi, F, Longo, M, Teperino, R, Ungaro, P, Di Jeso, B, Formisano, P, Beguinot, F, Miele, C

“…Aims/hypothesis Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of…”
Get full text

Erratum to: Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E by Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Beguinot, F., Van Obberghen, E.

Get full text

Hepatocyte nuclear factor (HNF)-4α-driven epigenetic silencing of the human PED gene by Ungaro, P, Teperino, R, Mirra, P, Longo, M, Ciccarelli, M, Raciti, G. A, Nigro, C, Miele, C, Formisano, P, Beguinot, F

“…Aims/hypothesis Overexpression of PED (also known as PEA15) determines insulin resistance and impaired insulin secretion and may contribute to progression…”
Get full text

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-β activity and TGF-β1 expression by Oriente, F, Iovino, S, Cassese, A, Romano, C, Miele, C, Troncone, G, Balletta, M, Perfetti, A, Santulli, G, Iaccarino, G, Valentino, R, Beguinot, F, Formisano, P

“…Aims/hypothesis Overproduction of phosphoprotein enriched in diabetes (PED, also known as phosphoprotein enriched in astrocytes-15 [PEA-15]) is a common…”
Get full text

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes by Valentino, R, Lupoli, G A, Raciti, G A, Oriente, F, Farinaro, E, Della Valle, E, Salomone, M, Riccardi, G, Vaccaro, O, Donnarumma, G, Sesti, G, Hribal, M L, Cardellini, M, Miele, C, Formisano, P, Beguinot, F

“…Overexpression of the gene encoding phosphoprotein enriched in astrocytes 15 (PEA15), also known as phosphoprotein enriched in diabetes (PED), causes insulin…”
Get full text