Search Results - "BEGG, A. C."

Hypoxia in head and neck cancer: How much, how important? by Janssen, H. L., Haustermans, K. M., Balm, A. J., Begg, A. C.

“…Background. Hypoxia develops in tumors because of a less ordered, often chaotic, and leaky vascular supply compared with that in normal tissues. In preclinical…”
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Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation by AWWAD, H. K, LOTAYEF, M, SHOUMAN, T, BEGG, A. C, WILSON, G, BENTZEN, S. M, EL-MONEIM, H. Abd, EISSA, S

“…Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration…”
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Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin–DNA adduct formation in patients and ovarian cancer cell lines by van de Vaart, P.J.M., van der Vange, N., Zoetmulder, F.A.N, van Goethem, A.R., van Tellingen, O., ten Bokkel Huinink, W.W., Beijnen, J.H., Bartelink, H., Begg, A.C.

“…The purpose of this study was to investigate the influence of hyperthermia on cisplatin pharmaco-kinetics and DNA adduct formation. The latter was investigated…”
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Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor by Hoebers, F. J. P., Pluim, D., Hart, A. A. M., Verheij, M., Balm, A. J. M., Fons, G., Rasch, C. R. N., Schellens, J. H. M., Stalpers, L. J. A., Bartelink, H., Begg, A. C.

“…Purpose In this study, the formation of cisplatin-DNA adducts after concurrent cisplatin-radiation and the relationship between adduct-formation in primary…”
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Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer by RUSSELL, N.S, GRUMMELS, A, HART, A.A.M, SMOLDERS, I.J.H, BORGER, J, BARTELINK, H, BEGG, A. C.

“…Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after…”
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DNA‐adduct levels as a predictor of outcome for NSCLC patients receiving daily cisplatin and radiotherapy by van de Vaart, Paul J. M., Belderbos, Jose, de Jong, Daphne, Sneeuw, Kommer C.A., Majoor, Donne, Bartelink, Harry, Begg, Adrian C.

“…We aimed to investigate whether biological factors related to radiosensitivity and chemosensitivity have prognostic significance in non‐small‐cell‐lung‐cancer…”
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Cisplatin and radiation: interaction probabilities and therapeutic possibilities by Begg, A C

“…This paper examines the probability of interactions occurring between drug lesions and radiation lesions in DNA for the cytotoxic and radiosensitizing agent…”
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Use of thymidine analogues to indicate vascular perfusion in tumours by BEGG, A. C, HOFLAND, I, VAN DER PAVERT, I, VAN DER SCHUEREN, B, HAUSTERMANS, K

“…Temporary reduction in blood-flow within tumour blood vessels can reduce oxygen supply leading to transient perfusion-limited hypoxia. Consequent selection of…”
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Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities by COCO-MARTIN, J. M, BEGG, A. C

“…A potential assay for radiosensitivity of human tumours is that of radiation-induced chromosome damage determined on metaphase spreads of human solid tumours…”
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The predictive value of cell kinetic measurements in a European trial of accelerated fractionation in advanced head and neck tumors: an interim report by Begg, A C, Hofland, I, Moonen, L, Bartelink, H, Schraub, S, Bontemps, P, Le Fur, R, Van Den Bogaert, W, Caspers, R, Van Glabbeke, M

“…The value of cell kinetic measurements in head and neck tumors in predicting which patients will benefit from accelerated fractionation radiotherapy regimens…”
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Cell kinetic measurements in prostate cancer by Haustermans, K M, Hofland, I, Van Poppel, H, Oyen, R, Van de Voorde, W, Begg, A C, Fowler, J F

“…Two approaches have been suggested for escalating the total dose in radiotherapy treatment of prostate cancer. One is conformal radiotherapy; the other is…”
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Rapid Fluorescence Ratio Assay for Detecting Changes in Radiosensitivity by Hofland, I., Ramakers, B., Begg, A. C., Vens, C.

“…Hofland, I., Ramakers, B., Begg, A. C. and Vens, C. Rapid Fluorescence Ratio Assay for Detecting Changes in Radiosensitivity. Radiat. Res. 157, 734–739 (2002)…”
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Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells by MARTIN, J. M. C, MOOREN, E, OTTENHEIM, C, BURRILL, W, NUNEZ, M. I, SPRONG, D, BARTELINK, H, BEGG, A. C

“…Purpose: To validate whether the number of aberrations could be used as a measure of the radiosensitivity of human tumour cells. If so, this would potentially…”
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In vitro differentiation characteristics of human skin fibroblasts: correlations with radiotherapy-induced breast fibrosis in patients by RUSSELL, N. S, LARA, P. C, GRUMMELS, A, HART, A. A. M, COCO-MARTIN, J. M, BARTELINK, H, BEGG, A. C

“…Purpose : To determine whether there is an association between dermal fibroblast differentiation characteristics in vitro and breast fibrosis developing in…”
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Radiation-induced differentiation of human skin fibroblasts: relationship with cell survival and collagen production by Lara, P C, Russell, N S, Smolders, I J, Bartelink, H, Begg, A C, Coco-Martin, J M

“…The aim of this study was to determine whether significant inter-individual differences exist between skin fibroblast strains obtained from radiotherapy…”
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Prediction of repopulation rates and radiosensitivity in human tumours by Begg, A C

“…An accurate prediction of response to radiotherapy would allow treatments to be modified for those individuals where a relatively poor response is expected…”
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Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient by BADIE, C, ILIAKIS, G, MALAISE, E. P, FORAY, N, ALSBEIH, G, PANTELLIAS, G. E, OKAYASU, R, NGE CHEONG, RUSSELL, N. S, BEGG, A. C, ARLETT, C. F

“…A radiation-sensitive fibroblast culture (180BR) established from an acute lymphoblastic leukemia patient who died following radiotherapy is defective in the…”
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Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy by Begg, A C, Russell, N S, Knaken, H, Lebesque, J V

“…Fibroblasts from breast cancer patients were obtained as outgrowths in vitro from punch biopsies and their radiosensitivity tested in early passages. Skin…”
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Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro by OLDENBURG, J, BEGG, A. C, VAN VUGT, M. J. H, RUEVEKAMP, M, SCHORNAGEL, J. H, PINEDO, H. M, LOS, G

“…Cisplatin resistance was developed in sublines of the CC531 rat colon adenocarcinoma cell line by continued low level drug exposure. Two relatively stable…”
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Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours by SMITH, K. A, HILL, S. A, BEGG, A. C, DENEKAMP, J

“…The DNA-binding fluorescent dye Hoechst 33342 (H33342) has been used in a series of investigations of the vascular parameters of two murine tumours. This dye…”
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