Search Results - "BEEH, Kai M"

Minimal Clinically Important Differences in Pharmacological Trials by JONES, Paul W, BEEH, Kai M, CHAPMAN, Kenneth R, DECRAMER, Marc, MAHLER, Donald A, WEDZICHA, Jadwiga A

“…The concept of a minimal clinically important difference (MCID) is well established. Here, we review the evidence base and methods used to define MCIDs as well…”
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Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme by Krug, Norbert, Hohlfeld, Jens M, Kirsten, Anne-Marie, Kornmann, Oliver, Beeh, Kai M, Kappeler, Dominik, Korn, Stephanie, Ignatenko, Stanislav, Timmer, Wolfgang, Rogon, Cordelia, Zeitvogel, Jana, Zhang, Nan, Bille, Joachim, Homburg, Ursula, Turowska, Agnieszka, Bachert, Claus, Werfel, Thomas, Buhl, Roland, Renz, Jonas, Garn, Holger, Renz, Harald

“…GATA3 is thought to be a critical checkpoint in allergic diathesis. In this study, a synthetic DNAzyme that catalyzes the inactivation of GATA3 when…”
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How Do Dual Long-Acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease? by Beeh, Kai M, Burgel, Pierre-Regis, Franssen, Frits M E, Lopez-Campos, Jose Luis, Loukides, Stelios, Hurst, John R, Fležar, Matjaž, Ulrik, Charlotte Suppli, Di Marco, Fabiano, Stolz, Daiana, Valipour, Arschang, Casserly, Brian, Ställberg, Björn, Kostikas, Konstantinos, Wedzicha, Jadwiga A

“…Decreasing the frequency and severity of exacerbations is one of the main goals of treatment for patients with chronic obstructive pulmonary disease. Several…”
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The Role of Bronchodilators in Preventing Exacerbations of Chronic Obstructive Pulmonary Disease by Beeh, Kai M

“…Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom…”
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Seasonal Distribution of COPD Exacerbations in the Prevention of Exacerbations With Tiotropium in COPD Trial by Rabe, Klaus F., MD, PhD, Fabbri, Leonardo M., MD, FCCP, Vogelmeier, Claus, MD, Kögler, Harald, MD, Schmidt, Hendrik, PhD, Beeh, Kai M., MD, Glaab, Thomas, MD

“…Background There is still a lack of data on the seasonality of exacerbations of COPD based on large randomized studies using COPD exacerbations as primary end…”
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The Role of Bronchodilators in Preventing Exacerbations of Chronic Obstructive Pulmonary Disease by Beeh, Kai M

“…Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom…”
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The environmental impact of inhaled therapy: making informed treatment choices by Woodcock, Ashley, Beeh, Kai M, Sagara, Hironori, Aumônier, Simon, Addo-Yobo, Emmanuel, Khan, Javaid, Vestbo, Jørgen, Tope, Helen

“…When selecting the best inhaler and drug combination for a patient with respiratory disease, a number of factors should be considered. While efficacy and…”
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Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo-controlled clinical cross-over-trial by Beeh, Kai M., Beier, Jutta, Meyer, Michael, Buhl, Roland, Zahlten, Rainer, Wolff, Gerhard

“…Asthma is characterized by increased recruitment of inflammatory cells from the circulation into the airways. As selectins mediate tethering and rolling of…”
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Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD by Vogelmeier, Claus, Hederer, Bettina, Glaab, Thomas, Schmidt, Hendrik, Rutten-van Mölken, Maureen P.M.H, Beeh, Kai M, Rabe, Klaus F, Fabbri, Leonardo M

“…An important goal in the treatment of COPD is the prevention of exacerbations. In this trial, the investigators found that treatment with tiotropium, as…”
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Long-term repeatability of induced sputum cells and inflammatory markers in stable, moderately severe COPD by Beeh, Kai M, Beier, Jutta, Kornmann, Oliver, Mander, Annette, Buhl, Roland

“…Neutrophilic inflammation is a major feature of COPD. Induced sputum is increasingly used to monitor inflammatory airway diseases. Although short-term…”
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The short, the long and the “ultra-long”: Why duration of bronchodilator action matters in chronic obstructive pulmonary disease by Beeh, Kai M., Beier, Jutta

“…Bronchodilators are the cornerstone of symptomatic treatment for all chronic obstructive pulmonary disease (COPD) severity stages when administered on a…”
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Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD by Cazzola, Mario, Beeh, Kai M, Price, David, Roche, Nicolas

“…Abstract The long-acting inhaled bronchodilators available for use in chronic obstructive pulmonary disease (COPD) vary in their pharmacological class (β2…”
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Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial by Beeh, Kai M, Glaab, Thomas, Stowasser, Susanne, Schmidt, Hendrik, Fabbri, Leonardo M, Rabe, Klaus F, Vogelmeier, Claus F

“…Data examining the characteristics of patients with frequent exacerbations of chronic obstructive pulmonary disease (COPD) and associated hospitalisations and…”
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And Then There Were Three: Time to Move Onward in COPD Drug Development Beyond LAMA/LABA/ICS at Last? by Beeh, Kai M.

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Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial by Beeh, Kai M, Singh, Dave, Di Scala, Lilla, Drollmann, Anton

“…Exercise limitation, dynamic hyperinflation, and exertional dyspnea are key features of symptomatic chronic obstructive pulmonary disease (COPD). We assessed…”
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Aclidinium improves exercise endurance, dyspnea, lung hyperinflation, and physical activity in patients with COPD: a randomized, placebo-controlled, crossover trial by Beeh, Kai M, Watz, Henrik, Puente-Maestu, Luis, de Teresa, Luis, Jarreta, Diana, Caracta, Cynthia, Garcia Gil, Esther, Magnussen, Helgo

“…This study evaluated the effects of aclidinium bromide, a long-acting muscarinic antagonist indicated for maintenance treatment of chronic obstructive…”
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ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD by Watz, Henrik, Troosters, Thierry, Beeh, Kai M, Garcia-Aymerich, Judith, Paggiaro, Pierluigi, Molins, Eduard, Notari, Massimo, Zapata, Antonio, Jarreta, Diana, Garcia Gil, Esther

“…The Phase IV, 8-week, randomized, double-blind, placebo-controlled ACTIVATE study (NCT02424344) evaluated the effect of aclidinium/formoterol (AB/FF) 400/12 μg…”
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“All I want for Christmas is Two”: The Advent of Novel Fixed-Combination Inhalers for COPD and Outlook for 2014 by Beeh, Kai M.

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Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4 by Beeh, Kai M, Kornmann, Oliver, Buhl, Roland, Culpitt, Sarah V, Giembycz, Mark A, Barnes, Peter J

“…Neutrophilic inflammation is a major feature of COPD. Several factors in bronchial secretions have been identified as chemoattractants for neutrophils. The…”
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Long-acting β-adrenoceptor agonists in the management of COPD: focus on indacaterol by Beier, Jutta, Beeh, Kai M

“…Bronchodilators are the cornerstone of severe chronic obstructive pulmonary disease (COPD) treatment to improve airflow, symptoms, exercise tolerance, and…”
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