Search Results - "BEDFORD, Joel S"

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy by Huang, Qian, Li, Fang, Liu, Xinjian, Li, Wenrong, Shi, Wei, Liu, Fei-Fei, O'Sullivan, Brian, He, Zhimin, Peng, Yuanlin, Tan, Aik-Choon, Zhou, Ling, Shen, Jingping, Han, Gangwen, Wang, Xiao-Jing, Thorburn, Jackie, Thorburn, Andrew, Jimeno, Antonio, Raben, David, Bedford, Joel S, Li, Chuan-Yuan

“…Cytotoxic cancer therapy can induce accelerated growth of surviving cancer cells, a phenomenon known as tumor repopulation. This report uncovers a mechanism by…”
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Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration by Li, Fang, Huang, Qian, Chen, Jiang, Peng, Yuanlin, Roop, Dennis R, Bedford, Joel S, Li, Chuan-Yuan

“…The ability to regenerate damaged tissues is a common characteristic of multicellular organisms. We report a role for apoptotic cell death in promoting wound…”
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Quantitative, Noninvasive Imaging of Radiation-Induced DNA Double-Strand Breaks In Vivo by WENRONG LI, FANG LI, QIAN HUANG, JINGPING SHEN, WOLF, Frank, YUJUN HE, XINJIAN LIU, HU, Y. Angela, BEDFORD, Joel S, LI, Chuan-Yuan

“…DNA double-strand breaks (DSB) are a major form of DNA damage and a key mechanism through which radiotherapy and some chemotherapeutic agents kill cancer…”
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Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis by Kato, Takamitsu A, Okayasu, Ryuichi, Bedford, Joel S.

“…We have observed that some of the DNA damage or damage product caused by irradiation of interphase cells persisted throughout the cell cycle, and resulted in…”
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Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles by Lin, Yu-Fen, Nagasawa, Hatsumi, Little, John B, Kato, Takamitsu A, Shih, Hung-Ying, Xie, Xian-Jin, Wilson, Jr, Paul F, Brogan, John R, Kurimasa, Akihiro, Chen, David J, Bedford, Joel S, Chen, Benjamin P C

“…We have examined cell-cycle dependence of chromosomal aberration induction and cell killing after high or low dose-rate γ irradiation in cells bearing DNA-PKcs…”
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Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM by PENG, Yuanlin, WOODS, Rick G, BEAMISH, Heather, YE, Ruiqiong, LEES-MILLER, Susan P, LAVIN, Martin F, BEDFORD, Joel S

“…Previous reports have suggested a connection between reduced levels of the catalytic subunit of DNA-dependent protein kinases (DNA-PKcs), a component of the…”
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Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation by Peng, Yuanlin, Zhang, Qinming, Nagasawa, Hatsumi, Okayasu, Ryuichi, Liber, Howard L., Bedford, Joel S.

“…Targeted gene silencing in mammalian cells by RNA interference (RNAi) using small interfering RNAs (siRNAs) was recently described by Elbashir et al. (S. M…”
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Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability by Nagasawa, Hatsumi, Little, John B., Lin, Yu-Fen, So, Sairei, Kurimasa, Akihiro, Peng, Yuanlin, Brogan, John R., Chen, David J., Bedford, Joel S., Chen, Benjamin P. C.

“…The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key functional element in the DNA-PK complex that drives nonhomologous end joining…”
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The Central Role of Cytogenetics in Radiation Biology by Bailey, Susan M., Kunkel, Stephen R., Bedford, Joel S., Cornforth, Michael N.

“…Radiation cytogenetics has a rich history seldom appreciated by those outside the field. Early radiobiology was dominated by physics and biophysical concepts…”
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Historical and Current Highlights in Radiation Biology: Has Anything Important Been Learned by Irradiating Cells? by Bedford, Joel S., Dewey, William C.

“…Bedford, J. S. and Dewey, W. C. Historical and Current Highlights in Radiation Biology: Has Anything Important Been Learned by Irradiating Cells? Radiat. Res…”
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Cell Killing and Chromosome Aberrations by Ionizing Radiations: Brother, Can You Paradigm? by Bedford, Joel S., Brown, J. Martin

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A Unique Role of the DNA Fragmentation Factor in Maintaining Genomic Stability by Yan, Bin, Wang, Huili, Peng, Yuanlin, Hu, Ye, Wang, He, Zhang, Xiuwu, Chen, Qi, Bedford, Joel S., Dewhirst, Mark W., Li, Chuan-Yuan

“…DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we…”
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VARIATIONS IN RADIOSENSITIVITY AMONG INDIVIDUALS: A POTENTIAL IMPACT ON RISK ASSESSMENT? by Kato, Takamitsu A, Wilson, Paul F, Nagasaw, Hatsumi, Peng, Yuanlin, Weil, Michael M, Little, John B, Bedford, Joel S

“…To have an impact on risk assessment for purposes of radiation protection recommendations, significantly broad variations in carcinogenic radiosensitivity…”
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A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans by Kato, Takamitsu A., Wilson, Paul F., Nagasawa, Hatsumi, Fitzek, Markus M., Weil, Michael M., Little, John B., Bedford, Joel S.

“…Cells from unaffected parents of retinoblastoma (RB) patients were previously shown to be hypersensitive to radiation induced G 1 arrest and cell killing [1]…”
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Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells by Kato, Takamitsu, Nagasawa, Hatsumi, Warner, Christy, Okayasu, Ryuichi, Bedford, Joel S.

“…Purpose: To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of…”
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Directional Genomic Hybridization (dGH) for Detection of Intrachromosomal Rearrangements by Robinson, Erin, McKenna, Miles J, Bedford, Joel S, Goodwin, Edwin H, Cornforth, Michael N, Bailey, Susan M, Ray, F Andrew

“…Fluorescence in situ Hybridization (FISH) techniques, including whole chromosome painting (WCP), spectral karyotyping (SKY), and multicolor FISH (mFISH), are…”
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Persistence of Gamma-H2AX Foci in Bronchial Cells Correlates with Susceptibility to Radiation Associated Lung Cancer in Mice by Ochola, Donasian O., Sharif, Rabab, Bedford, Joel S., Keefe, Thomas J., Kato, Takamitsu A., Fallgren, Christina M., Demant, Peter, Costes, Sylvain V., Weila, Michael M.

“…The risk of developing radiation-induced lung cancer differs between different strains of mice, but the underlying cause of the strain differences is unknown…”
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Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells by Cornforth, Michael N., Anur, Pavana, Wang, Nicholas, Robinson, Erin, Ray, F. Andrew, Bedford, Joel S., Loucas, Bradford D., Williams, Eli S., Peto, Myron, Spellman, Paul, Kollipara, Rahul, Kittler, Ralf, Gray, Joe W., Bailey, Susan M.

“…Chromosome rearrangements are large-scale structural variants that are recognized drivers of oncogenic events in cancers of all types. Cytogenetics allows for…”
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Monitoring Genomic Structural Rearrangements Resulting from Gene Editing by Bailey, Susan M, Cross, Erin M, Kinner-Bibeau, Lauren, Sebesta, Henry C, Bedford, Joel S, Tompkins, Christopher J

“…The cytogenomics-based methodology of directional genomic hybridization (dGH) enables the detection and quantification of a more comprehensive spectrum of…”
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Radiosensitization of Normal Human Cells by LY294002：Cell Killing and the Rejoining of DNA and Interphase Chromosome Breaks by Okayasu, Ryuichi, Takakura, Kaoru, Poole, Shannon, Bedford, Joel S

“…The radiosensitizing effect of a phosphoinositide-3 kinase (PI3K) inhibitor, wortmannin, has been studied rather extensively, but there have been few studies…”
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