Search Results - "BECKNER, Marie"

A roadmap for potassium buffering/dispersion via the glial network of the CNS by Beckner, Marie E.

“…Glia use multiple mechanisms to mediate potassium fluxes that support neuronal function. In addition to changes in potassium levels within synapses, these ions…”
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Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas by Beckner, Marie E., Fellows‐Mayle, Wendy, Zhang, Zhe, Agostino, Naomi R., Kant, Jeffrey A., Day, Billy W., Pollack, Ian F.

“…Glioblastomas, the most malignant type of glioma, are more glycolytic than normal brain tissue. Robust migration of glioblastoma cells has been previously…”
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Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis by BECKNER, Marie E, GOBBEL, Glenn T, ABOUNADER, Roger, BUROVIC, Fatima, AGOSTINO, Naomi R, LATERRA, John, POLLACK, Ian F

“…Increased glycolysis is characteristic of malignancy. Previously, with a mitochondrial inhibitor, we demonstrated that glycolytic ATP production was sufficient…”
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Glioblastomas with copy number gains in EGFR and RNF139 show increased expressions of carbonic anhydrase genes transformed by ENO1 by Beckner, Marie E., Pollack, Ian F., Nordberg, Mary L., Hamilton, Ronald L.

“…Prominence of glycolysis in glioblastomas may be non-specific or a feature of oncogene-related subgroups (i.e. amplified EGFR, etc.). Relationships between…”
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Abstract 2670: Spatial potassium buffering among clustered glioblastoma cells is proposed to enable survival scavenging of nutrients released by interior necrotic cells by Beckner, Marie

“…Glioblastoma cells are known for surviving harsh environments and for forming secondary structures of Scherer (cell clusters around neurons/axons, blood…”
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Rapid detection of high-level oncogene amplifications in ultrasonic surgical aspirations of brain tumors by Truong, Long N, Patil, Shashikant, Martin, Sherry S, LeBlanc, Jay F, Nanda, Anil, Nordberg, Mary L, Beckner, Marie E

“…Genomic tumor information, such as identification of amplified oncogenes, can be used to plan treatment. The two sources of a brain tumor that are commonly…”
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Low-Level Amplification of Oncogenes Correlates Inversely with Age for Patients with Nontypical Meningiomas by Beckner, Marie E, Sampath, Raghuram, Flowers, Ashley B, Katira, Kristopher, D'Souza, Dwain, Patil, Shashikant, Patel, Raj B, Nordberg, Mary L, Nanda, Anil

“…Background This study sought to identify genes in nontypical meningiomas with gains in copy number (CN) that correlate with earlier age of onset, an indicator…”
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Abstract 2319: Expressions of genes encoding pH-sensitive potassium channels differ between oligodendrogliomas and glioblastomas with potential metabolic effects by Beckner, Marie E.

“…Potassium, the major intracellular cation, is released by neurons as they fire action potentials. Glial cells take up released K+ ions and later return them…”
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Abstract 3726: Expressions of genes for connexins and Kir5.1 differ between oligodendrogliomas and glioblastomas in patients treated with anticonvulsants by Beckner, Marie E.

“…Background: Glia in the CNS buffer potassium ions released by neurons as they fire action potentials. Glial activity occurs at synapses, along axons, and…”
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Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies by BECKNER, Marie E, XUAN CHEN, JIYAN AN, DAY, Billy W, POLLACK, Ian F

“…Malignant gliomas (astrocytomas) are lethal tumors that invade the brain. Invasive cell migration is initiated by extension of pseudopodia into interstitial…”
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Blockade of Angio-Associated Migratory Cell Protein Inhibits Smooth Muscle Cell Migration and Neointima Formation in Accelerated Atherosclerosis by Vogt, Felix, MD, Zernecke, Alma, MD, Beckner, Marie, PhD, Krott, Nicole, MSc, Bosserhoff, Anja-Katrin, PhD, Hoffmann, Rainer, MD, Zandvoort, Marc A.M.J., PhD, Jahnke, Thomas, MD, Kelm, Malte, MD, Weber, Christian, MD, Blindt, Rüdiger, MD

“…Blockade of Angio-Associated Migratory Cell Protein Inhibits Smooth Muscle Cell Migration and Neointima Formation in Accelerated Atherosclerosis Felix Vogt,…”
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Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth by Beckner, Marie E, Jane, Esther P, Jankowitz, Brian, Agostino, Naomi R, Walter, Kevin A, Hamilton, Ronald L, Pollack, Ian F

“…Abstract Studies of primary cells from malignant brain tumors such as glioblastomas are limited by the small size of surgically resected specimens. However,…”
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Abstract 6034: Detection of potassium channel (KCN) gene expression, often multiple and pH sensitive, in cancer genomic landscapes, as low to mid level genes of interest, suggests potassium transmembrane flow may enable proton efflux in a Goldilocks manner by Beckner, Marie E.

“…A reversed pH gradient across cell membranes underlies multiple malignant features, including invasiveness. Extracellular low pH activates metalloproteases and…”
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Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serum by Beckner, Marie E, Zhang, Zhe, Agostino, Naomi R, Day, Billy W, Pollack, Ian F

“…It is well accepted that dysfunction in the blood brain barrier (BBB) allows permeation of albumin from the bloodstream into astrocytic brain tumors,…”
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Abstract 3039: Decreased pH-sensitive potassium channel gene expressions in glioblastomas compared to oligodendrogliomas detected with house keeping genes may shift glioblastoma membrane potentials towards proton efflux to the microenvironment by Beckner, Marie E.

“…Glial buffering of K+ prevents seizures, hence gliomas in patients on anticonvulsants may harbor potassium related anomalies. Cell membrane potentials are very…”
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Extracellular Angio-Associated Migratory Cell Protein Plays a Positive Role in Angiogenesis and Is Regulated by Astrocytes in Coculture by Beckner, Marie E., Jagannathan, Syamala, Peterson, Virginia A.

“…The extracellular form of angio-associated migratory cell protein (AAMP), a recently discovered protein, plays a positive role in angiogenesis and can be…”
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Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma: a case report by BECKNER, Marie E, LEE, John Y. K, SCHOCHET, Sydney S, CHU, Charleen T

“…Intracranial EMH is only occasionally found in primary brain tumors (mostly hemangioblastomas) and, to our knowledge, this is the first case of EMH associated…”
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Abstract 3940: Transformation by ENO1 highlights the positive relationship between HIF1A's and VEGFA's RNA expression levels, putatively by counteracting heterogeneity in glioblastomas by Beckner, Marie E., Pollack, Ian F., Hamilton, Ronald L.

“…Analysis of metabolic gene expression is compromised by tumor heterogeneity. Therefore, we investigated the use of RNA expression levels from ENO1, which…”
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Expression of Carbonic Anhydrase Genes, CA3 and CA12, Transformed with ENO1, Relate to Copy Numbers of EGFR or RNF139 and XIAP, and Gender in Glioblastomas Using PCR Assays by Beckner, Marie, Pollack, Ian, Nordberg, Mary, Hamilton, Ronald

“…Abstract only Relationships between amplified oncogenes and glycolysis were studied in glioblastomas (GBs) using ENO1 to define supraphysiologic metabolic gene…”
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Loss of heterozygosity reveals non- VHL allelic loss in hemangioblastomas at 22q13 by Beckner, Marie E., Sasatomi, Eizaburo, Swalsky, Patricia A., Hamilton, Ronald L., Pollack, Ian F., Finkelstein, Sydney D.

“…Hemangioblastomas (HBs) are low-grade (World Health Organization grade I/IV) central nervous system (CNS) tumors that frequently contain VHL (3p26) mutations…”
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