Search Results - "BECKERS, Linda"

Hypercholesterolemia‐induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis by Seijkens, Tom, Hoeksema, Marten A., Beckers, Linda, Smeets, Esther, Meiler, Svenja, Levels, Johannes, Tjwa, Marc, Winther, Menno P. J., Lutgens, Esther

“…ABSTRACT Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell function. In this study, we investigated how hypercholesterolemia…”
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Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis by Lievens, Dirk, Zernecke, Alma, Seijkens, Tom, Soehnlein, Oliver, Beckers, Linda, Munnix, Imke C.A., Wijnands, Erwin, Goossens, Pieter, van Kruchten, Roger, Thevissen, Larissa, Boon, Louis, Flavell, Richard A., Noelle, Randolph J., Gerdes, Norbert, Biessen, Erik A., Daemen, Mat J.A.P., Heemskerk, Johan W.M., Weber, Christian, Lutgens, Esther

“…CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic…”
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Diet‐induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow by Berg, Susan M., Seijkens, Tom T. P., Kusters, Pascal J. H., Beckers, Linda, Toom, Myrthe, Smeets, Esther, Levels, Johannes, Winther, Menno P. J., Lutgens, Esther

“…Obesity is associated with chronic low‐grade inflammation, characterized by leukocytosis and inflammation in the adipose tissue. Continuous activation of the…”
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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance by Chatzigeorgiou, Antonios, Seijkens, Tom, Zarzycka, Barbara, Engel, David, Poggi, Marjorie, van den Berg, Susan, van den Berg, Sjoerd, Soehnlein, Oliver, Winkels, Holger, Beckers, Linda, Lievens, Dirk, Driessen, Ann, Kusters, Pascal, Biessen, Erik, Garcia-Martin, Ruben, Amelna, Anne Klotzsche-von, Gijbels, Marion, Noelle, Randolph, Boon, Louis, Hackeng, Tilman, Schulte, Klaus, Xu, Aimin, Vriend, Gert, Nabuurs, Sander, Chung, Kyoung-Jin, van Dijk, Ko Willems, Rensen, Patrick C. N., Gerdes, Norbert, de Winther, Menno, Block, Norman L., Schally, Andrew V., Webere, Christian, Bornstein, Stefan R., Nicolaes, Gerry, Chavakis, Triantafyllos, Lutgens, Esther

“…The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling…”
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Adipocytes control hematopoiesis and inflammation through CD40 signaling by Reiche, Myrthe E, Poels, Kikkie, Bosmans, Laura A, Vos, Winnie G, Van Tiel, Claudia M, Gijbels, Marion J J, Aarts, Suzanne A B M, Den Toom, Myrthe, Beckers, Linda, Weber, Christian, Atzler, Dorothee, Rensen, Patrick C N, Kooijman, Sander, Lutgens, Esther

“…The co-stimulatory CD40-CD40L dyad plays an important role in chronic inflammatory diseases associated with aging. Although CD40 is mainly expressed by immune…”
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Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile by Lutgens, Esther, Lievens, Dirk, Beckers, Linda, Wijnands, Erwin, Soehnlein, Oliver, Zernecke, Alma, Seijkens, Tom, Engel, David, Cleutjens, Jack, Keller, Anna M, Naik, Shalin H, Boon, Louis, Oufella, Hafid Ait, Mallat, Ziad, Ahonen, Cory L, Noelle, Randolph J, de Winther, Menno P, Daemen, Mat J, Biessen, Erik A, Weber, Christian

“…The CD40-CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory…”
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Atherosclerotic Plaque Destabilization in Mice: A Comparative Study by Hartwig, Helene, Silvestre-Roig, Carlos, Hendrikse, Jeffrey, Beckers, Linda, Paulin, Nicole, Van der Heiden, Kim, Braster, Quinte, Drechsler, Maik, Daemen, Mat J, Lutgens, Esther, Soehnlein, Oliver

“…Atherosclerosis-associated diseases are the main cause of mortality and morbidity in western societies. The progression of atherosclerosis is a dynamic process…”
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CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice by Poggi, Marjorie, Engel, David, Christ, Anette, Beckers, Linda, Wijnands, Erwin, Boon, Louis, Driessen, Ann, Cleutjens, Jack, Weber, Christian, Gerdes, Norbert, Lutgens, Esther

“…OBJECTIVE—Obese adipose tissue shows hallmarks of chronic inflammation, which promotes the development of metabolic disorders. The mechanisms by which immune…”
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Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis by Wolfs, Ine M. J., Stöger, J. Lauran, Goossens, Pieter, Pöttgens, Chantal, Gijbels, Marion J. J., Wijnands, Erwin, Vorst, Emiel P. C., Gorp, Patrick, Beckers, Linda, Engel, David, Biessen, Erik A. L., Kraal, Georg, Die, Irma, Donners, Marjo M. P. C., Winther, Menno P. J.

“…Atherosclerosis is a lipid‐driven inflammatory disease of the vessel wall, characterized by the chronic activation of macrophages. We investigated whether the…”
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Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice by Braster, Quinte, Silvestre Roig, Carlos, Hartwig, Helene, Beckers, Linda, den Toom, Myrthe, Döring, Yvonne, Daemen, Mat J, Lutgens, Esther, Soehnlein, Oliver

“…Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation of the…”
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Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE -/- Mice by Kane, Jamie, Vos, Winnie G, Bosmans, Laura A, van Os, Bram W, den Toom, Myrthe, Hoeksema-Hackmann, Sanne, Moen-de Wit, Denise, Gijbels, Marion J, Beckers, Linda, Grefhorst, Aldo, Levels, Johannes H M, Jakulj, Lily, Vervloet, Marc G, Lutgens, Esther, Eringa, Etto C

“…Atherosclerosis is highly prevalent in people with chronic kidney disease (CKD), including those receiving peritoneal dialysis (PD). Although it is lifesaving,…”
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T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation by Vos, Winnie G, van Os, Bram W, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy P A A, van Tiel, Claudia M, Mohapatra, Bhopal C, Band, Hamid, Nitz, Katrin, Weber, Christian, Atzler, Dorothee, de Winther, Menno P J, Bosmans, Laura A, Lutgens, Esther, Seijkens, Tom T P

“…Atherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases. Recent…”
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Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis by Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther

“…The costimulatory CD40L–CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expressed on MHCII+ B cells, dendritic cells and macrophages in…”
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Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction by Aarts, Suzanne A B M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, Gijbels, Marion J J, Gerdes, Norbert, de Winther, Menno P J, Lutgens, Esther

“…Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced…”
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Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques by Harber, Karl J., Neele, Annette E., van Roomen, Cindy PAA, Gijbels, Marion JJ, Beckers, Linda, Toom, Myrthe den, Schomakers, Bauke V., Heister, Daan AF, Willemsen, Lisa, Griffith, Guillermo R., de Goede, Kyra E., van Dierendonck, Xanthe AMH, Reiche, Myrthe E., Poli, Aurélie, L-H Mogensen, Frida, Michelucci, Alessandro, Verberk, Sanne GS, de Vries, Helga, van Weeghel, Michel, Van den Bossche, Jan, de Winther, Menno PJ

“…Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards…”
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CD70 limits atherosclerosis and promotes macrophage function by Winkels, Holger, Meiler, Svenja, Smeets, Esther, Lievens, Dirk, Engel, David, Spitz, Charlotte, Bürger, Christina, Rinne, Petteri, Beckers, Linda, Dandl, Angelika, Reim, Sigrid, Ahmadsei, Maiwand, Van den Bossche, Jan, Holdt, Lesca M, Megens, Remco T A, Schmitt, Martin, de Winther, Menno, Biessen, Eric A, Borst, Jannie, Faussner, Alexander, Weber, Christian, Lutgens, Esther, Gerdes, Norbert

“…The co-stimulatory molecule CD70 is expressed on activated immune cells and is known to modulate responses of T, B, and NK cells via its receptor CD27. Until…”
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The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis by Engel, David, Seijkens, Tom, Poggi, Marjorie, Sanati, Maryam, Thevissen, Larissa, Beckers, Linda, Wijnands, Erwin, Lievens, Dirk, Lutgens, Esther

“…Abstract Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the…”
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Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation by Aarts, Suzanne A B M, Seijkens, Tom T P, Kusters, Pascal J H, van der Pol, Susanne M A, Zarzycka, Barbara, Heijnen, Priscilla D A M, Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J J, Boon, Louis, Weber, Christian, de Vries, Helga E, Nicolaes, Gerry A F, Dijkstra, Christine D, Kooij, Gijs, Lutgens, Esther

“…The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies…”
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Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis by van Os, Bram W, Kusters, Pascal J H, den Toom, Myrthe, Beckers, Linda, van Tiel, Claudia M, Vos, Winnie G, de Jong, Elize, Kieser, Arnd, van Roomen, Cindy, Binder, Christoph J, Reiche, Myrthe E, de Winther, Menno P, Bosmans, Laura A, Lutgens, Esther

“…Atherosclerosis is the underlying cause of many cardiovascular diseases, such as myocardial infarction or stroke. B cells, and their production of pro- and…”
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The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling by Donners, Marjo M.P.C., Beckers, Linda, Lievens, Dirk, Munnix, Imke, Heemskerk, Johan, Janssen, Ben J., Wijnands, Erwin, Cleutjens, Jack, Zernecke, Alma, Weber, Christian, Ahonen, Cory L., Benbow, Ulrike, Newby, Andrew C., Noelle, Randolph J., Daemen, Mat J.A.P., Lutgens, Esther

“…We investigated the role of CD40 and CD40L in neointima formation and identified the downstream CD40-signaling intermediates (tumor necrosis factor…”
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