Search Results - "BECKER, S."

Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy by Mandal, R, Becker, S, Strebhardt, K

“…The RAS-RAF-MEK1/2-ERK1/2 pathway is a key signal transduction pathway in the cells. Critically, it remains constitutively active in approximately 30% of human…”
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Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations by Zhang, Yu, McCord, Rachel Patton, Ho, Yu-Jui, Lajoie, Bryan R., Hildebrand, Dominic G., Simon, Aline C., Becker, Michael S., Alt, Frederick W., Dekker, Job

“…The extent to which the three-dimensional organization of the genome contributes to chromosomal translocations is an important question in cancer genomics. We…”
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Balloon inflation revisited by Baaser, H., Becker, S.

“…In the present work, an inexpensive setup of an experiment of balloon inflation is described in order to measure its pressure and diameter. As already children…”
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The role of Plk3 in oncogenesis by Helmke, C, Becker, S, Strebhardt, K

“…The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that play essential roles in many cellular processes involved in the…”
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Science may be objective, scientists are not always by S, Becker

“…“Historically, most things, most people ever believed to be true eventually turned out not to be true.“ We live in the age of science. At least, that is what…”
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Automatic classification of ultrasound breast lesions using a deep convolutional neural network mimicking human decision-making by Ciritsis, Alexander, Rossi, Cristina, Eberhard, Matthias, Marcon, Magda, Becker, Anton S., Boss, Andreas

“…Objectives To evaluate a deep convolutional neural network (dCNN) for detection, highlighting, and classification of ultrasound (US) breast lesions mimicking…”
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Selection and expansion of natural killer cells for NK cell-based immunotherapy by Becker, Petra S. A., Suck, Garnet, Nowakowska, Paulina, Ullrich, Evelyn, Seifried, Erhard, Bader, Peter, Tonn, Torsten, Seidl, Christian

“…Natural killer (NK) cells have been used in several clinical trials as adaptive immunotherapy. The low numbers of these cells in peripheral blood mononuclear…”
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Classification of breast cancer in ultrasound imaging using a generic deep learning analysis software: a pilot study by Becker, Anton S, Mueller, Michael, Stoffel, Elina, Marcon, Magda, Ghafoor, Soleen, Boss, Andreas

“…To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable…”
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Mitotic transcription and waves of gene reactivation during mitotic exit by Palozola, Katherine C., Donahue, Greg, Liu, Hong, Grant, Gregory R., Becker, Justin S., Cote, Allison, Yu, Hongtao, Raj, Arjun, Zaret, Kenneth S.

“…Although the genome is generally thought to be transcriptionally silent during mitosis, technical limitations have prevented sensitive mapping of transcription…”
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Residents’ Reactions to Earthquake Early Warnings in Japan by Nakayachi, Kazuya, Becker, Julia S., Potter, Sally H., Dixon, Maximilian

“…This article empirically examines the effectiveness of earthquake early warning (EEW) in Japan based on experiences of residents who received warnings before…”
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Backup flexibility classes in emerging large-scale renewable electricity systems by Schlachtberger, D.P., Becker, S., Schramm, S., Greiner, M.

“…•Flexible backup demand in a European wind and solar based power system is modelled.•Three flexibility classes are defined based on production and consumption…”
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Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes by Becker, Justin S., McCarthy, Ryan L., Sidoli, Simone, Donahue, Greg, Kaeding, Kelsey E., He, Zhiying, Lin, Shu, Garcia, Benjamin A., Zaret, Kenneth S.

“…Heterochromatin is integral to cell identity maintenance by impeding the activation of genes for alternate cell fates. Heterochromatic regions are associated…”
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A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia by Lee, Su-In, Celik, Safiye, Logsdon, Benjamin A., Lundberg, Scott M., Martins, Timothy J., Oehler, Vivian G., Estey, Elihu H., Miller, Chris P., Chien, Sylvia, Dai, Jin, Saxena, Akanksha, Blau, C. Anthony, Becker, Pamela S.

“…Cancers that appear pathologically similar often respond differently to the same drug regimens. Methods to better match patients to drugs are in high demand…”
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Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes by Caravaca, Juan Manuel, Donahue, Greg, Becker, Justin S, He, Ximiao, Vinson, Charles, Zaret, Kenneth S

“…While most transcription factors exit the chromatin during mitosis and the genome becomes silent, a subset of factors remains and "bookmarks" genes for rapid…”
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New diagnostic tools in schistosomiasis by Utzinger, J., Becker, S.L., van Lieshout, L., van Dam, G.J., Knopp, S.

“…Schistosomiasis is a water-based parasitic disease that affects over 250 million people. Control efforts have long been in vain, which is one reason why…”
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Climate change scenarios in fisheries and aquatic conservation research by Burgess, M G, Becker, S L, Langendorf, R E, Fredston, A, Brooks, C M

“…Abstract Scenarios are central to fisheries and aquatic conservation research on climate change. Scenarios project future greenhouse-gas emissions, which…”
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Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group by Modest, D.P., Ricard, I., Heinemann, V., Hegewisch-Becker, S., Schmiegel, W., Porschen, R., Stintzing, S., Graeven, U., Arnold, D., von Weikersthal, L.F., Giessen-Jung, C., Stahler, A., Schmoll, H.J., Jung, A., Kirchner, T., Tannapfel, A., Reinacher-Schick, A.

“…To explore the impact of KRAS, NRAS and BRAF mutations as well as KRAS mutation variants in patients with metastatic colorectal cancer (mCRC) receiving…”
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Vertebral body insufficiency fractures: detection of vertebrae at risk on standard CT images using texture analysis and machine learning by Muehlematter, Urs J., Mannil, Manoj, Becker, Anton S., Vokinger, Kerstin N., Finkenstaedt, Tim, Osterhoff, Georg, Fischer, Michael A., Guggenberger, Roman

“…Purpose To evaluate the diagnostic performance of bone texture analysis (TA) combined with machine learning (ML) algorithms in standard CT scans to identify…”
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Multidisciplinary Recommendations Regarding Post-Vaccine Adenopathy and Radiologic Imaging: Radiology Scientific Expert Panel by Becker, Anton S, Perez-Johnston, Rocio, Chikarmane, Sona A, Chen, Melissa M, El Homsi, Maria, Feigin, Kimberly N, Gallagher, Katherine M, Hanna, Ehab Y, Hicks, Marshall, Ilica, Ahmet T, Mayer, Erica L, Shinagare, Atul B, Yeh, Randy, Mayerhoefer, Marius E, Hricak, Hedvig, Vargas, H Alberto

“…Vaccination-associated adenopathy is a frequent imaging finding after administration of COVID-19 vaccines that may lead to a diagnostic conundrum in patients…”
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miR-9 Controls the Timing of Neurogenesis through the Direct Inhibition of Antagonistic Factors by Coolen, Marion, Thieffry, Denis, Drivenes, Øyvind, Becker, Thomas S., Bally-Cuif, Laure

“…The timing of commitment and cell-cycle exit within progenitor populations during neurogenesis is a fundamental decision that impacts both the number and…”
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