Search Results - "BECHERINI, Pamela"

Mesenchymal Stem Cell‐Derived Extracellular Vesicles as Mediators of Anti‐Inflammatory Effects: Endorsement of Macrophage Polarization by Lo Sicco, Claudia, Reverberi, Daniele, Balbi, Carolina, Ulivi, Valentina, Principi, Elisa, Pascucci, Luisa, Becherini, Pamela, Bosco, Maria Carla, Varesio, Luigi, Franzin, Chiara, Pozzobon, Michela, Cancedda, Ranieri, Tasso, Roberta

“…Mesenchymal Stem Cells (MSCs) are effective therapeutic agents enhancing the repair of injured tissues mostly through their paracrine activity. Increasing…”
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Fasting-mimicking diet and hormone therapy induce breast cancer regression by Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G., Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G., Provenzani, Alessandro, Longo, Valter D., Nencioni, Alessio

“…Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors. Endocrine therapy is usually effective in these…”
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Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair by Piacente, Francesco, Caffa, Irene, Ravera, Silvia, Sociali, Giovanna, Passalacqua, Mario, Vellone, Valerio G, Becherini, Pamela, Reverberi, Daniele, Monacelli, Fiammetta, Ballestrero, Alberto, Odetti, Patrizio, Cagnetta, Antonia, Cea, Michele, Nahimana, Aimable, Duchosal, Michel, Bruzzone, Santina, Nencioni, Alessio

“…In the last decade, substantial efforts have been made to identify NAD biosynthesis inhibitors, specifically against nicotinamide phosphoribosyltransferase…”
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Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity by Khalifa, Amr, Guijarro, Ana, Ravera, Silvia, Bertola, Nadia, Adorni, Maria Pia, Papotti, Bianca, Raffaghello, Lizzia, Benelli, Roberto, Becherini, Pamela, Namatalla, Asmaa, Verzola, Daniela, Reverberi, Daniele, Monacelli, Fiammetta, Cea, Michele, Pisciotta, Livia, Bernini, Franco, Caffa, Irene, Nencioni, Alessio

“…Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing…”
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Author Correction: Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity by Khalifa, Amr, Guijarro, Ana, Ravera, Silvia, Bertola, Nadia, Adorni, Maria Pia, Papotti, Bianca, Raffaghello, Lizzia, Benelli, Roberto, Becherini, Pamela, Namatalla, Asmaa, Verzola, Daniela, Reverberi, Daniele, Monacelli, Fiammetta, Cea, Michele, Pisciotta, Livia, Bernini, Franco, Caffa, Irene, Nencioni, Alessio

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Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment by Soncini, Debora, Martinuzzi, Claudia, Becherini, Pamela, Gelli, Elisa, Ruberti, Samantha, Todoerti, Katia, Mastracci, Luca, Contini, Paola, Cagnetta, Antonia, Laudisi, Antonella, Guolo, Fabio, Minetto, Paola, Miglino, Maurizio, Aquino, Sara, Varaldo, Riccardo, Reverberi, Daniele, Formica, Matteo, Passalacqua, Mario, Nencioni, Alessio, Neri, Antonino, Samur, Mehmet K, Munshi, Nikhil C, Fulciniti, Mariateresa, Lemoli, Roberto M, Cea, Michele

“…Identification of novel vulnerabilities in the context of therapeutic resistance is emerging as a key challenge for cancer treatment. Recent studies have…”
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Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass by Raggi, Federica, Cangelosi, Davide, Becherini, Pamela, Blengio, Fabiola, Morini, Martina, Acquaviva, Massimo, Belli, Maria Luisa, Panizzon, Giuseppe, Cervo, Giuseppe, Varesio, Luigi, Eva, Alessandra, Bosco, Maria Carla

“…Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and…”
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Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor by PASTORINO, Fabio, LOI, Monica, SAPRA, Puja, BECHERINI, Pamela, CILLI, Michele, EMIONITE, Laura, RIBATTI, Domenico, GREENBERGER, Lee M, HORAK, Ivan D, PONZONI, Mirco

“…Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of a water soluble pegylated SN38 drug…”
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SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice by Becherini, Pamela, Caffa, Irene, Piacente, Francesco, Damonte, Patrizia, Vellone, Valerio G, Passalacqua, Mario, Benzi, Andrea, Bonfiglio, Tommaso, Reverberi, Daniele, Khalifa, Amr, Ghanem, Moustafa, Guijarro, Ana, Tagliafico, Luca, Sucameli, Marzia, Persia, Angelica, Monacelli, Fiammetta, Cea, Michele, Bruzzone, Santina, Ravera, Silvia, Nencioni, Alessio

“…Sirtuin 6 (SIRT6) is a NAD -dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast…”
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Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma by Loi, Monica, Marchiò, Serena, Becherini, Pamela, Di Paolo, Daniela, Soster, Marco, Curnis, Flavio, Brignole, Chiara, Pagnan, Gabriella, Perri, Patrizia, Caffa, Irene, Longhi, Renato, Nico, Beatrice, Bussolino, Federico, Gambini, Claudio, Ribatti, Domenico, Cilli, Michele, Arap, Wadih, Pasqualini, Renata, Allen, Theresa M., Corti, Angelo, Ponzoni, Mirco, Pastorino, Fabio

“…The therapeutic index of anti-cancer drugs is increased when encapsulating them in tumor-targeted liposomes. Liposome-entrapped doxorubicin (DXR), targeting…”
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SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells by Sociali, Giovanna, Grozio, Alessia, Caffa, Irene, Schuster, Susanne, Becherini, Pamela, Damonte, Patrizia, Sturla, Laura, Fresia, Chiara, Passalacqua, Mario, Mazzola, Francesca, Raffaelli, Nadia, Garten, Antje, Kiess, Wieland, Cea, Michele, Nencioni, Alessio, Bruzzone, Santina

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Abstract 5609: Bortezomib enhanced cytotoxic effects of novel sTRAIL-targeted nanocarriers against neuroectodermal tumors by Loi, Monica, Giacomini, Arianna, Becherini, Pamela, Pastorino, Fabio, Ponzoni, Mirco

“…Abstract The soluble form of the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (sTRAIL) is a cancer cell-specific molecule exerting anti-tumor…”
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CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD + -Lowering Agents by Becherini, Pamela, Soncini, Debora, Ravera, Silvia, Gelli, Elisa, Martinuzzi, Claudia, Giorgetti, Giulia, Cagnetta, Antonia, Guolo, Fabio, Ivaldi, Federico, Miglino, Maurizio, Aquino, Sara, Todoerti, Katia, Neri, Antonino, Benzi, Andrea, Passalacqua, Mario, Nencioni, Alessio, Perrotta, Ida, Gallo Cantafio, Maria Eugenia, Amodio, Nicola, De Flora, Antonio, Bruzzone, Santina, Lemoli, Roberto M, Cea, Michele

“…Cancer cells fuel growth and energy demands by increasing their NAD biosynthesis dependency, which therefore represents an exploitable vulnerability for…”
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The use of the orthotopic model to validate antivascular therapies for cancer by Loi, Monica, Di Paolo, Daniela, Becherini, Pamela, Zorzoli, Alessia, Perri, Patrizia, Carosio, Roberta, Cilli, Michele, Ribatti, Domenico, Brignole, Chiara, Pagnan, Gabriella, Ponzoni, Mirco, Pastorino, Fabio

“…The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression,…”
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The Multi-Kinases Inhibitor ARQ531 Enhanches Anti-MM Activity of Imids By Dual Deregulation of MAP- and Cyclin-Dependent Kinases Activities by Soncini, Debora, Becherini, Pamela, Gelli, Elisa, Martinuzzi, Claudia, Guolo, Fabio, Neri, Antonino, Cagnetta, Antonia, Lemoli, Roberto Massimo, Cea, Michele

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SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells by Sociali, Giovanna, Grozio, Alessia, Caffa, Irene, Schuster, Susanne, Becherini, Pamela, Damonte, Patrizia, Sturla, Laura, Fresia, Chiara, Passalacqua, Mario, Mazzola, Francesca, Raffaelli, Nadia, Garten, Antje, Kiess, Wieland, Cea, Michele, Nencioni, Alessio, Bruzzone, Santina

“…ABSTRACT Nicotinamide phosphoribosyltransferase (NAMPT) is the rate‐limiting enzyme in the NAD+ salvage pathway from nicotinamide. By controlling the…”
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The NAD + Metabolic Dependency Restriction Overcomes Drug-Resistance Phenotype of Multiple Myeloma CELLS by Soncini, Debora, Becherini, Pamela, Ravera, Silvia, Martinuzzi, Claudia, Nencioni, Alessio, Bruzzone, Santina, Piacente, Francesco, Giorgetti, Giulia, Ladisa, Francesco, Duchosal, Michel A., Nahimana, Aimable, Lemoli, Roberto M., Cea, Michele

“…Introduction: We previously reported that Nicotinamide Adenine Dinucleotide (NAD +), a master regulator of catabolic metabolism and several enzymatic…”
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Clonal Hematopoiesis: Exploiting Molecular Landscape of Multiple Myeloma Patients for Choosing the Most Appropriate Therapeutic Strategy by Gelli, Elisa, Laudisi, Antonella, Martinuzzi, Claudia, Soncini, Debora, Becherini, Pamela, Guolo, Fabio, Conticello, Concetta, Derudas, Daniele, Di Raimondo, Francesco, Cagnetta, Antonia, Coviello, Domenico, Lemoli, Roberto Massimo, Cea, Michele

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First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential by Balbi, Carolina, Piccoli, Martina, Barile, Lucio, Papait, Andrea, Armirotti, Andrea, Principi, Elisa, Reverberi, Daniele, Pascucci, Luisa, Becherini, Pamela, Varesio, Luigi, Mogni, Massimo, Coviello, Domenico, Bandiera, Tiziano, Pozzobon, Michela, Cancedda, Ranieri, Bollini, Sveva

“…Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease…”
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Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies by Giorgetti, Giulia, Becherini, Pamela, Maroto-Martin, Elena, Fenoglio, Daniela, Soncini, Debora, Martinuzzi, Claudia, Bruzzone, Santina, Benzi, Andrea, Nahimana, Aimable, Uras, Chiara Rosa Maria, Schavgoulidze, Anaïs, Ng Fong, Jessica, Lemoli, Roberto M., Munshi, Nikhil C, Fulciniti, Mariateresa, Cea, Michele

“…NCAM1 (Neural Cell Adhesion Molecule 1), also known as CD56, is a member of the immunoglobulin superfamily and is deregulated in many tumors. In multiple…”
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