Search Results - "BEBBINGTON, Christopher R"

Discovery, Function, and Therapeutic Targeting of Siglec-8 by Youngblood, Bradford A, Leung, John, Falahati, Rustom, Williams, Jason, Schanin, Julia, Brock, Emily C, Singh, Bhupinder, Chang, Alan T, O'Sullivan, Jeremy A, Schleimer, Robert P, Tomasevic, Nenad, Bebbington, Christopher R, Bochner, Bruce S

“…Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these,…”
Get full text

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product by Finney, Helene M, Lawson, Alastair D. G, Bebbington, Christopher R, Weir, A. Neil C

“…Single chain Fv chimeric receptors, or T-bodies, are described with intracellular sequences comprising the costimulatory signaling domain of CD28 in series…”
Get full text

The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells by Pogue, Sarah L, Preston, Benjamin T, Stalder, Joseph, Bebbington, Christopher R, Cardarelli, Pina M

“…Type I interferons (IFNs) are potent regulators of both innate and adaptive immunity. All type I IFNs bind to the same heterodimeric cell surface receptor…”
Get more information

CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: Implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors by CHIN PAN, CARDARELLI, Pina M, SALLES, Adam, CHEN, Tseng-Hui, HORGAN, Killian, WANG, Yi-Hong, THI NGUYEN, BEBBINGTON, Christopher R, NIEDER, Matthew H, PICKFORD, Lesley B, GANGWAR, Sanjeev, KING, David J, YARRANTON, Geoffrey T, BUCKMAN, Dana, ROSCOE, William, FENGMIN ZHOU

“…Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present…”
Get full text

Immunotherapeutic Targeting of EphA3 by Charmsaz, Sara, Miller, Kirrilee J, Day, Bryan W, El-Ajeh, Fares, Palath, Varghese, Yarranton, Geoff T, Bebbington, Christopher R, Scott, Andrew M, Lackmann, Martin, Boyd, Andrew W

“…Eph receptors form the largest family of receptor tyrosine kinases. Eph receptors interact with cell-surface ephrin ligands to direct cell growth and…”
Get full text

EphA3 As a Target For Monoclonal Antibody Therapy For Acute Leukemia by Charmsaz, Sara, Miller, Kirrilee J, Day, Bryan W, El-Ajeh, Fares, Yarranton, Geoff T, Bebbington, Christopher R, Scott, Andrew M, Lackmann, Martin, Boyd, Andrew W

“…Eph receptor tyrosine kinases interact with cell-surface ephrin ligands to direct cell growth, migration and cell positioning. High expression of EphA3 in a…”
Get full text

The use of engineered E1A genes to transactivate the hCMV-MIE promoter in permanent CHO cell lines by CROCKETT, M. I, BEBBINGTON, C. R, YARRANTON, G. T

“…Vectors expressing adenovirus 5 E1A or a domain 2 mutant E1A were introduced into CHO-K1 cells in order to transactivate the hCMV-MIE promoter in transient and…”
Get full text