Search Results - "BEAUSANG, John F"

Tilting and Wobble of Myosin V by High-Speed Single-Molecule Polarized Fluorescence Microscopy by Beausang, John F., Shroder, Deborah Y., Nelson, Philip C., Goldman, Yale E.

“…Myosin V is biomolecular motor with two actin-binding domains (heads) that take multiple steps along actin by a hand-over-hand mechanism. We used high-speed…”
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Quaternary InGaAsSb Thermophotovoltaic Diodes by Dashiell, Michael W., Beausang, John F., Ehsani, Hassan, Nichols, G. J., Depoy, David M., Danielson, Lee R., Talamo, Phil, Rahner, Kevin D., Brown, Edward J., Burger, Steven R., Fourspring, Patrick M., Topper, William F., Baldasaro, P. F., Wang, Christine A., Huang, Robin K., Connors, Michael K., Turner, George W., Shellenbarger, Zane A., Taylor, Gordon, Li, Jizhong, Martinelli, Ramon, Donetski, Dmitry, Anikeev, Sergei, Belenky, Gregory L., Luryi, Serge

“…In x Ga 1-x As y Sb 1-y thermophotovoltaic (TPV) diodes were grown lattice matched to GaSb substrates by metal-organic vapor phase epitaxy in the bandgap range…”
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Concentration and length dependence of DNA looping in transcriptional regulation by Han, Lin, Garcia, Hernan G, Blumberg, Seth, Towles, Kevin B, Beausang, John F, Nelson, Philip C, Phillips, Rob

“…In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter…”
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Twirling of Actin by Myosins II and V Observed via Polarized TIRF in a Modified Gliding Assay by Beausang, John F., Schroeder, Harry W., Nelson, Philip C., Goldman, Yale E.

“…The force generated between actin and myosin acts predominantly along the direction of the actin filament, resulting in relative sliding of the thick and thin…”
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Evaluation of cell-free DNA approaches for multi-cancer early detection by Jamshidi, Arash, Liu, Minetta C., Klein, Eric A., Venn, Oliver, Hubbell, Earl, Beausang, John F., Gross, Samuel, Melton, Collin, Fields, Alexander P., Liu, Qinwen, Zhang, Nan, Fung, Eric T., Kurtzman, Kathryn N., Amini, Hamed, Betts, Craig, Civello, Daniel, Freese, Peter, Calef, Robert, Davydov, Konstantin, Fayzullina, Saniya, Hou, Chenlu, Jiang, Roger, Jung, Byoungsok, Tang, Susan, Demas, Vasiliki, Newman, Joshua, Sakarya, Onur, Scott, Eric, Shenoy, Archana, Shojaee, Seyedmehdi, Steffen, Kristan K., Nicula, Virgil, Chien, Tom C., Bagaria, Siddhartha, Hunkapiller, Nathan, Desai, Mohini, Dong, Zhao, Richards, Donald A., Yeatman, Timothy J., Cohn, Allen L., Thiel, David D., Berry, Donald A., Tummala, Mohan K., McIntyre, Kristi, Sekeres, Mikkael A., Bryce, Alan, Aravanis, Alexander M., Seiden, Michael V., Swanton, Charles

“…In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer…”
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Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes by Gee, Marvin H., Han, Arnold, Lofgren, Shane M., Beausang, John F., Mendoza, Juan L., Birnbaum, Michael E., Bethune, Michael T., Fischer, Suzanne, Yang, Xinbo, Gomez-Eerland, Raquel, Bingham, David B., Sibener, Leah V., Fernandes, Ricardo A., Velasco, Andrew, Baltimore, David, Schumacher, Ton N., Khatri, Purvesh, Quake, Stephen R., Davis, Mark M., Garcia, K. Christopher

“…The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well…”
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Surgical and molecular characterization of primary and metastatic disease in a neuroendocrine tumor arising in a tailgut cyst by Erdrich, Jennifer, Schaberg, Kurt B, Khodadoust, Michael S, Zhou, Li, Shelton, Andrew A, Visser, Brendan C, Ford, James M, Alizadeh, Ash A, Quake, Stephen R, Kunz, Pamela L, Beausang, John F

“…Neuroendocrine tumors (NETs) arising from tailgut cysts are a rare but increasingly reported entity with gene expression profiles that may be indicative of the…”
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Elongation factor G initiates translocation through a power stroke by Chen, Chunlai, Cui, Xiaonan, Beausang, John F., Zhang, Haibo, Farrell, Ian, Cooperman, Barry S., Goldman, Yale E.

“…During the translocation step of prokaryotic protein synthesis, elongation factor G (EF-G), a guanosine triphosphatase (GTPase), binds to the ribosomal…”
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T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire by Beausang, John F., Wheeler, Amanda J., Chan, Natalie H., Hanft, Violet R., Dirbas, Frederick M., Jeffrey, Stefanie S., Quake, Stephen R.

“…Tumor-infiltrating T cells play an important role in many cancers, and can improve prognosis and yield therapeutic targets. We characterized T cells…”
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Myosin VI lever arm rotation: Fixed or variable? by Sun, Yujie, Schroeder, Harry W. III, Beausang, John F, Homma, Kazuaki, Ikebe, Mitsuo, Goldman, Yale E

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Tethered Particle Motion as a Diagnostic of DNA Tether Length by Nelson, Philip C, Zurla, Chiara, Brogioli, Doriano, Beausang, John F, Finzi, Laura, Dunlap, David

“…The tethered particle motion (TPM) technique involves an analysis of the Brownian motion of a bead tethered to a slide by a single DNA molecule. We describe an…”
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B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy by Beausang, John F, Fan, H Christina, Sit, Rene, Hutchins, Maria U, Jirage, Kshama, Curtis, Rachael, Hutchins, Edward, Quake, Stephen R, Yabu, Julie M

“…Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte…”
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Myosin VI Walks “Wiggly” on Actin with Large and Variable Tilting by Sun, Yujie, Schroeder, Harry W., Beausang, John F., Homma, Kazuaki, Ikebe, Mitsuo, Goldman, Yale E.

“…Myosin VI is an unconventional motor protein with unusual motility properties such as its direction of motion and path on actin and a large stride relative to…”
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Genome-wide sequencing for early stage lung cancer detection from plasma cell-free DNA (cfDNA): The Circulating Cancer Genome Atlas (CCGA) study by Oxnard, Geoffrey R., Maddala, Tara, Hubbell, Earl, Aravanis, Alex, Zhang, Nan, Venn, Oliver, Valouev, Anton, Shen, Ling, Patel, Shilpen, Jamshidi, Arash, Jagadeesh, Karthik, Gross, Samuel, Filippova, Darya, Beausang, John F., Liu, Minetta C., Richards, Donald A., Plevritis, Sylvia, Williams, Richard Thomas, Hartman, Anne-Renee, Swanton, Charles

“…Abstract only LBA8501 Background: Plasma cfDNA genomic analysis is used widely for the care of advanced lung cancer, but its suitability for early stage lung…”
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Prevalence of clonal hematopoiesis of indeterminate potential (CHIP) measured by an ultra-sensitive sequencing assay: Exploratory analysis of the Circulating Cancer Genome Atlas (CCGA) study by Swanton, Charles, Venn, Oliver, Aravanis, Alex, Hubbell, Earl, Maddala, Tara, Beausang, John F., Filippova, Darya, Gross, Samuel, Jamshidi, Arash, Shen, Ling, Valouev, Anton, Zhang, Nan, Bolton, Kelly L, Yeatman, Timothy Joseph, Seiden, Michael, Oxnard, Geoffrey R., Liu, Minetta C., Williams, Richard Thomas, Hartman, Anne-Renee, Baselga, Jose

“…Abstract only…”
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Changepoint analysis for single-molecule polarized total internal reflection fluorescence microscopy experiments by Beausang, John F, Goldman, Yale E, Nelson, Philip C

“…The experimental study of individual macromolecules has opened a door to determining the details of their mechanochemical operation. Motor enzymes such as the…”
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First-principles calculation of DNA looping in tethered particle experiments by Towles, Kevin B, Beausang, John F, Garcia, Hernan G, Phillips, Rob, Nelson, Philip C

“…We calculate the probability of DNA loop formation mediated by regulatory proteins such as Lac repressor (LacI), using a mathematical model of DNA elasticity…”
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DNA Looping Kinetics Analyzed Using Diffusive Hidden Markov Model by Beausang, John F., Zurla, Chiara, Manzo, Carlo, Dunlap, David, Finzi, Laura, Nelson, Philip C.

“…Tethered particle experiments use light microscopy to measure the position of a micrometer-sized bead tethered to a microscope slide via an approximately…”
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The azimuthal path of myosin V and its dependence on lever-arm length by Lewis, John H, Beausang, John F, Sweeney, H Lee, Goldman, Yale E

“…Myosin V (myoV) is a two-headed myosin capable of taking many successive steps along actin per diffusional encounter, enabling it to transport vesicular and…”
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Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM) by Beausang, John F, Sun, Yujie, Quinlan, Margot E, Forkey, Joseph N, Goldman, Yale E

“…In this article, we describe methods to detect the spatial orientation and rotational dynamics of single molecules using polarized total internal reflection…”
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