Search Results - "BEAUNE, P. H"

Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9 by Lecoeur, S, André, C, Beaune, P H

“…Tienilic acid-induced hepatitis is characterized by the presence of anti-liver and -kidney microsomal (anti-LKM2) autoantibodies in patient sera. Cytochrome…”
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Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues by de Waziers, I, Cugnenc, P H, Yang, C S, Leroux, J P, Beaune, P H

“…The organ distribution of microsomal cytochrome P 450 isoenzymes (P 450), microsomal epoxide hydrolase (EH) and cytosolic glutathione-S-transferases was…”
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Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism by Guengerich, F P, Martin, M V, Beaune, P H, Kremers, P, Wolff, T, Waxman, D J

“…The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism among individual humans…”
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Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens by Shimada, T, Yun, C H, Yamazaki, H, Gautier, J C, Beaune, P H, Guengerich, F P

“…Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities towards several xenobiotic…”
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Is diclofenac a valuable CYP2C9 probe in humans? by MORIN, S, LORIOT, M. A, POIRIER, J. M, TENNEZE, L, BEAUNE, P. H, FUNCK-BRENTANO, C, JAILLON, P, BECQUEMONT, L

“…Besides the low therapeutic index drug tolbutamide, there is no validated in vivo probe to assess the genetically determined CYP2C9 activity in humans. The in…”
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Immunotoxicology of the liver: adverse reactions to drugs by Beaune, Philippe H., Lecoeur, Sylvaine

“…Liver is a frequent target for drug-induced hepatitis. They can be classified in two categories: the hepatitis in which the drug or a metabolite reach a vital…”
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Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2 : a specific marker of dihydralazine-induced hepatitis by BOURDI, M, LARREY, D, NATAF, J, BERNUAU, J, PESSAYRE, D, IWASAKI, M, GUENGERICH, F. P, BEAUNE, P. H

“…Sera from patients with dihydralazine-induced hepatitis were shown to contain anti-liver microsomal autoantibodies (anti-LM) by indirect immunofluorescence…”
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Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes by Kerlan, V, Dreano, Y, Bercovici, J P, Beaune, P H, Floch, H H, Berthou, F

“…Kinetics of the 2- and 4-hydroxylations of estradiol (E2) by human liver microsomal samples were studied to determine the major P450 isoform involved in these…”
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Indirect Cytotoxicity of Flucloxacillin toward Human Biliary Epithelium via Metabolite Formation in Hepatocytes by Lakehal, Fatima, Dansette, Patrick M, Becquemont, Laurent, Lasnier, Elisabeth, Delelo, Roland, Balladur, Pierre, Poupon, Raoul, Beaune, Philippe H, Housset, Chantal

“…Flucloxacillin, an isoxazolyl-penicillin, causes cholestasis and biliary epithelium injury. The aim of the study was to determine whether flucloxacillin,…”
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Phase I and Phase II drug‐metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium by Lakehal, Fatima, Wendum, Dominique, Barbu, Véronique, Becquemont, Laurent, Poupon, Raoul, Balladur, Pierre, Hannoun, Laurent, Ballet, François, Beaune, Philippe H., Housset, Chantal

“…Tissue expression of drug‐metabolizing enzymes influences susceptibility to drugs and carcinogens. Because the biliary epithelium, exposed to bile‐borne…”
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Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes by Berthou, F, Guillois, B, Riche, C, Dreano, Y, Jacqz-Aigrain, E, Beaune, P H

“…1. Interspecies (including man, monkey, rabbit, rat and mouse) variations in caffeine metabolism by liver microsomes were studied. While N-3 demethylation was…”
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Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity by Bork, R W, Muto, T, Beaune, P H, Srivastava, P K, Lloyd, R S, Guengerich, F P

“…P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a bacteriophage λgt11 expression…”
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Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide by Walker, D, Flinois, J P, Monkman, S C, Beloc, C, Boddy, A V, Cholerton, S, Daly, A K, Lind, M J, Pearson, A D, Beaune, P H

“…Two NADPH-dependent metabolic routes for the anticancer drug ifosfamide, 4-hydroxylation (activation) and N-dechloroethylation (a detoxication pathway), were…”
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Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake by Perrot, N, Nalpas, B, Yang, C S, Beaune, P H

“…Cytochromes P450 (P450) are a family of isozymes which play an important role in xenobiotic metabolism. The concentration of three P450 isozymes, namely…”
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Drug-induced immunotoxicity by Dansette, P M, Bonierbale, E, Minoletti, C, Beaune, P H, Pessayre, D, Mansuy, D

“…Immune-related drug responses are one of the most common sources of idiosyncratic toxicity. A number of organs may be the target of such reactions; however,…”
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Isolation and Sequence Determination of a cDNA Clone Related to Human Cytochrome P-450 Nifedipine Oxidase by Beaune, Philippe H., Umbenhauer, Diane R., Bork, Richard W., Lloyd, R. Stephen, Guengerich, F. Peter

“…Human liver cytochrome P-450NFis the form of cytochrome P-450 responsible for the oxidation of the calcium-channel blocker nifedipine, which has been reported…”
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Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies by Bourdi, M, Tinel, M, Beaune, P H, Pessayre, D

“…The antihypertensive drug dihydralazine may, on rare occasions, cause immunoallergic hepatitis characterized by anti-cytochrome P450 (P450)1A2 autoantibodies…”
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Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes by Srivastava, P K, Yun, C H, Beaune, P H, Ged, C, Guengerich, F P

“…Purification and immunoinhibition studies have suggested that the hydroxylations of (S)-mephenytoin and tolbutamide are catalyzed by rather similar forms of…”
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Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug by Bourdi, M, Gautier, J C, Mircheva, J, Larrey, D, Guillouzo, A, Andre, C, Belloc, C, Beaune, P H

“…Anti-liver microsomes (anti-LM) autoantibodies in patients with dihydralazine-induced hepatitis were found to react specifically with cytochrome P4501A2…”
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Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation by Dansette, P M, Amar, C, Valadon, P, Pons, C, Beaune, P H, Mansuy, D

“…Tienilic acid (TA) is metabolized by human liver microsomes in the presence of NADPH with the major formation of 5-hydroxytienilic acid (5-OHTA) which is…”
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