Search Results - "BEAUNE, P"

Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease by Chouchana, L., Narjoz, C., Beaune, P., Loriot, M.-A., Roblin, X.

“…Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background  Thiopurines represent an effective and widely prescribed therapy in inflammatory bowel disease…”
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Optimization of Initial Tacrolimus Dose Using Pharmacogenetic Testing by Thervet, E, Loriot, M A, Barbier, S, Buchler, M, Ficheux, M, Choukroun, G, Toupance, O, Touchard, G, Alberti, C, Le Pogamp, P, Moulin, B, Le Meur, Y, Heng, A E, Subra, J F, Beaune, P, Legendre, C

“…Retrospective studies have demonstrated that patients who are expressors of cytochrome P4503A5 (CYP3A5) require a higher tacrolimus dose to achieve a…”
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Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin by Gouin‐Thibault, I., Delavenne, X., Blanchard, A., Siguret, V., Salem, J. E., Narjoz, C., Gaussem, P., Beaune, P., Funck‐Brentano, C., Azizi, M., Mismetti, P., Loriot, M. A.

“…Essentials Rivaroxaban and dabigatran are substrates of the P‐glycoprotein (P‐gp) encoded by the ABCB1 gene. We tested the effect of ABCB1 polymorphisms and of…”
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Pharmacogenetics and other factors in individualization of oral anti-vitamine k anti-coagulants by Beaune, P

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Genetic Factors ( and ) Are Predictor Variables for Warfarin Response in Very Elderly, Frail Inpatients by Pautas, E, Moreau, C, Gouin‐Thibault, I, Golmard, J‐L, Mahé, I, Legendre, C, Taillandier‐Hériche, E, Durand‐Gasselin, B, Houllier, A‐M, Verrier, P, Beaune, P, Loriot, M‐A, Siguret, V

“…Determining the optimal dose of warfarin for frail elderly patients is a challenging task because of the low dose requirements in such patients, the wide…”
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Long‐Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype by Pallet, N., Etienne, I., Buchler, M., Bailly, E., Hurault de Ligny, B., Choukroun, G., Colosio, C., Thierry, A., Vigneau, C., Moulin, B., Le Meur, Y., Heng, A.‐E., Legendre, C., Beaune, P., Loriot, M. A., Thervet, E.

“…Pretransplantation adaptation of the daily dose of tacrolimus to CYP3A5 genotype is associated with improved achievement of target trough concentration (C0),…”
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Analgesic effect of acetaminophen in humans: First evidence of a central serotonergic mechanism by Pickering, Gisèle, Loriot, Marie‐Anne, Libert, Frédéric, Eschalier, Alain, Beaune, Philippe, Dubray, Claude

“…Objectives Preclinical studies have suggested that the mechanism of the analgesic action of acetaminophen (INN, paracetamol) is linked to the serotonergic…”
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Cyclosporine‐Induced Endoplasmic Reticulum Stress Triggers Tubular Phenotypic Changes and Death by Pallet, N., Bouvier, N., Bendjallabah, A., Rabant, M., Flinois, J. P., Hertig, A., Legendre, C., Beaune, P., Thervet, E., Anglicheau, D.

“…The molecular mechanisms by which cyclosporine induces chronic nephrotoxicity remain poorly understood. A previous transcriptomic study suggested that…”
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Kidney Transplant Recipients Carrying the CYP3A422 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations by Pallet, N., Jannot, A.‐S., El Bahri, M., Etienne, I., Buchler, M., de Ligny, B. H., Choukroun, G., Colosio, C., Thierry, A., Vigneau, C., Moulin, B., Le Meur, Y., Heng, A.‐E., Subra, J.‐F., Legendre, C., Beaune, P., Alberti, C., Loriot, M. A., Thervet, E.

“…CYP3A4*22 is an allelic variant of the cytochrome P450 3A4 associated with a decreased activity. Carriers of this polymorphism may require reduced tacrolimus…”
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Predictive Modeling of Tacrolimus Dose Requirement Based on High‐Throughput Genetic Screening by Damon, C., Luck, M., Toullec, L., Etienne, I., Buchler, M., Hurault de Ligny, B., Choukroun, G., Thierry, A., Vigneau, C., Moulin, B., Heng, A.‐E., Subra, J.‐F., Legendre, C., Monnot, A., Yartseva, A., Bateson, M., Laurent‐Puig, P., Anglicheau, D., Beaune, P., Loriot, M. A., Thervet, E., Pallet, N.

“…Any biochemical reaction underlying drug metabolism depends on individual gene–drug interactions and on groups of genes interacting together. Based on a…”
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Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine–sirolimus interaction by Anglicheau, D., Pallet, N., Rabant, M., Marquet, P., Cassinat, B., Méria, P., Beaune, P., Legendre, C., Thervet, E.

“…Cyclosporine nephrotoxicity remains a major side effect in solid organ transplantation, and can be exacerbated by concomitant administration of sirolimus…”
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Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma by LIEVRE, A, BLONS, H, HOULLIER, A. M, LACCOURREYE, O, BRASNU, D, BEAUNE, P, LAURENT-PUIG, P

“…Mitochondrial DNA mutations have been reported in several types of tumours, including head and neck squamous cell carcinoma (HNSCC). The noncoding region of…”
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A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia by Le Clerc, S, Taing, L, Fond, G, Meary, A, Llorca, P-M, Blanc, O, Beaune, P, Rajagopal, K, Jamain, S, Tamouza, R, Zagury, J-F, Leboyer, M

“…The choice of an efficient psychotropic treatment for patients with schizophrenia is a key issue to improve prognosis and quality of life and to decrease the…”
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Influence of genetics and non-genetic factors on acenocoumarol maintenance dose requirement in Moroccan patients by Smires, F. Z., Moreau, C., Habbal, R., Siguret, V., Fadili, S., Golmard, J. L., Assaidi, A., Beaune, P., Loriot, M. A., Nadifi, S.

“…Summary What is known and Objective:  Coumarin derivatives such as acenocoumarol represent the therapy of choice for the long‐term treatment and prevention of…”
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NMR metabolomic of frontal cortex extracts: First study comparing two neurodegenerative diseases, Alzheimer disease and amyotrophic lateral sclerosis by Botosoa, E.P, Zhu, M, Marbeuf-Gueye, C, Triba, M.N, Dutheil, F, Duyckäerts, C, Beaune, P, Loriot, M.A, Le Moyec, L

“…Abstract Objective This study was designed to assess the brain metabolites’ variability between two neurodegenerative diseases in frontal cortex samples…”
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TEGDMA Modulates Glutathione Transferase P1 Activity in Gingival Fibroblasts by Lefeuvre, M., Bourd, K., Loriot, M.-A., Goldberg, M., Beaune, P., Périanin, A., Stanislawski, L.

“…Dental resinous materials can contain large amounts (from 30 to 50%) of triethylene-glycol-dimethacrylate (TEGDMA). This compound leaches into aqueous media…”
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Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9 by Lecoeur, S, André, C, Beaune, P H

“…Tienilic acid-induced hepatitis is characterized by the presence of anti-liver and -kidney microsomal (anti-LKM2) autoantibodies in patient sera. Cytochrome…”
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Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response by Fougeray, S, Bouvier, N, Beaune, P, Legendre, C, Anglicheau, D, Thervet, E, Pallet, N

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Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues by de Waziers, I, Cugnenc, P H, Yang, C S, Leroux, J P, Beaune, P H

“…The organ distribution of microsomal cytochrome P 450 isoenzymes (P 450), microsomal epoxide hydrolase (EH) and cytosolic glutathione-S-transferases was…”
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UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? by Stücker, I, Loriot, M A, N'koutchou, G, Cénée, S, Bodin, L, Mulot, C, Gelu-Simeon, M, Pelletier, L, Bronowicki, J P, Degos, F, Beaune, P, Laurent-Puig, P, Hémon, D, Trinchet, J C, Pelletier, G

“…We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma…”
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