Search Results - "BEAULOYE, Christophe"

AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury by Marino, Alice, Hausenloy, Derek J., Andreadou, Ioanna, Horman, Sandrine, Bertrand, Luc, Beauloye, Christophe

“…Heart failure is one of the leading causes of death and disability worldwide. Left ventricle remodeling, fibrosis, and ischemia/reperfusion injury all…”
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AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation by Daskalopoulos, Evangelos P, Dufeys, Cécile, Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine

“…Abstract Fibrosis is a general term encompassing a plethora of pathologies that span all systems and is marked by increased deposition of collagen. Injury of…”
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Glucose transporters in cardiovascular system in health and disease by Bertrand, Luc, Auquier, Julien, Renguet, Edith, Angé, Marine, Cumps, Julien, Horman, Sandrine, Beauloye, Christophe

“…Glucose transporters are essential for the heart to sustain its function. Due to its nature as a high energy-consuming organ, the heart needs to catabolize a…”
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Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols by Penna, Claudia, Andreadou, Ioanna, Aragno, Manuela, Beauloye, Christophe, Bertrand, Luc, Lazou, Antigone, Falcão‐Pires, Ines, Bell, Robert, Zuurbier, Coert J., Pagliaro, Pasquale, Hausenloy, Derek J.

“…Diabetic patients are at increased risk of developing coronary artery disease and experience worse clinical outcomes following acute myocardial infarction…”
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AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation by Gélinas, Roselle, Mailleux, Florence, Dontaine, Justine, Bultot, Laurent, Demeulder, Bénédicte, Ginion, Audrey, Daskalopoulos, Evangelos P., Esfahani, Hrag, Dubois-Deruy, Emilie, Lauzier, Benjamin, Gauthier, Chantal, Olson, Aaron K., Bouchard, Bertrand, Des Rosiers, Christine, Viollet, Benoit, Sakamoto, Kei, Balligand, Jean-Luc, Vanoverschelde, Jean-Louis, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc

“…AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte…”
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Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK by Angin, Yeliz, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc

“…This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein…”
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Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function by Zacchigna, Serena, Paldino, Alessia, Falcão-Pires, Inês, Daskalopoulos, Evangelos P, Dal Ferro, Matteo, Vodret, Simone, Lesizza, Pierluigi, Cannatà, Antonio, Miranda-Silva, Daniela, Lourenço, André P, Pinamonti, Bruno, Sinagra, Gianfranco, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Kehat, Izhak, Tocchetti, Carlo G, Russo, Michele, Ghigo, Alessandra, Cimino, James, Hirsch, Emilio, Dawson, Dana, Ciccarelli, Michele, Oliveti, Marco, Linke, Wolfgang A, Cuijpers, Ilona, Heymans, Stephane, Hamdani, Nazha, de Boer, Martine, Duncker, Dirk J, Kuster, Diederik, van der Velden, Jolanda, Beauloye, Christophe, Bertrand, Luc, Mayr, Manuel, Giacca, Mauro, Leuschner, Florian, Backs, Johannes, Thum, Thomas

“…Abstract Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant…”
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IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action by Lecour, Sandrine, Andreadou, Ioanna, Bøtker, Hans Erik, Davidson, Sean M., Heusch, Gerd, Ruiz-Meana, Marisol, Schulz, Rainer, Zuurbier, Coert J., Ferdinandy, Péter, Hausenloy, Derek J.

“…Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new…”
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Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues by Maes, Arne, Pestiaux, Camille, Marino, Alice, Balcaen, Tim, Leyssens, Lisa, Vangrunderbeeck, Sarah, Pyka, Grzegorz, De Borggraeve, Wim M., Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine, Wevers, Martine, Kerckhofs, Greet

“…Biological tissues comprise a spatially complex structure, composition and organization at the microscale, named the microstructure. Given the close…”
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AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism by Dufeys, Cécile, Daskalopoulos, Evangelos-Panagiotis, Castanares-Zapatero, Diego, Conway, Simon J., Ginion, Audrey, Bouzin, Caroline, Ambroise, Jérôme, Bearzatto, Bertrand, Gala, Jean-Luc, Heymans, Stephane, Papageorgiou, Anna-Pia, Vinckier, Stefan, Cumps, Julien, Balligand, Jean-Luc, Vanhaverbeke, Maarten, Sinnaeve, Peter, Janssens, Stefan, Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine

“…We have previously demonstrated that systemic AMP-activated protein kinase α1 (AMPKα1) invalidation enhanced adverse LV remodelling by increasing fibroblast…”
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Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction by Roy, Clotilde, Slimani, Alisson, de Meester, Christophe, Amzulescu, Mihaela, Pasquet, Agnes, Vancraeynest, David, Beauloye, Christophe, Vanoverschelde, Jean-Louis, Gerber, Bernhard L, Pouleur, Anne-Catherine

“…Increased myocardial fibrosis may play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology. The study aim was to evaluate the…”
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Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning by Crisafulli, Antonio, Pagliaro, Pasquale, Roberto, Silvana, Cugusi, Lucia, Mercuro, Giuseppe, Lazou, Antigone, Beauloye, Christophe, Bertrand, Luc, Hausenloy, Derek J, Aragno, Manuela, Penna, Claudia

“…Metabolic syndrome, diabetes, and ischemic heart disease are among the leading causes of death and disability in Western countries. Diabetic cardiomyopathy is…”
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New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans by Ferté, Laura, Marino, Alice, Battault, Sylvain, Bultot, Laurent, Van Steenbergen, Anne, Bol, Anne, Cumps, Julien, Ginion, Audrey, Koepsell, Hermann, Dumoutier, Laure, Hue, Louis, Horman, Sandrine, Bertrand, Luc, Beauloye, Christophe

“…Although sodium glucose cotransporter 1 (SGLT1) has been identified as one of the major SGLT isoforms expressed in the heart, its exact role remains elusive…”
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Sex Differences of the Diabetic Heart by Fourny, Natacha, Beauloye, Christophe, Bernard, Monique, Horman, Sandrine, Desrois, Martine, Bertrand, Luc

“…Type 2 diabetes is a chronic disease associated with micro- and macro-vascular complications, including myocardial ischemia, and also with a specific and…”
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Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes by Lafosse, Aurore, Dufeys, Cécile, Beauloye, Christophe, Horman, Sandrine, Dufrane, Denis

“…Adipose-derived stem cells (ASC) are currently proposed for wound healing in those with type 2 diabetes mellitus (T2DM). Therefore, this study investigated the…”
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Enhanced Expression of β3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase by Belge, Catharina, Hammond, Joanna, Dubois-Deruy, Emilie, Manoury, Boris, Hamelet, Julien, Beauloye, Christophe, Markl, Andreas, Pouleur, Anne-Catherine, Bertrand, Luc, Esfahani, Hrag, Jnaoui, Karima, Götz, Konrad R, Nikolaev, Viacheslav O, Vanderper, Annelies, Herijgers, Paul, Lobysheva, Irina, Iaccarino, Guido, Hilfiker-Kleiner, Denise, Tavernier, Geneviève, Langin, Dominique, Dessy, Chantal, Balligand, Jean-Luc

“…BACKGROUND—β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is…”
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Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK by Angé, Marine, De Poortere, Julien, Ginion, Audrey, Battault, Sylvain, Dechamps, Mélanie, Muccioli, Giulio G., Roumain, Martin, Morelle, Johann, Druart, Sébastien, Mathivet, Thomas, Bertrand, Luc, Castanares-Zapatero, Diego, Horman, Sandrine, Beauloye, Christophe

“…Sepsis capillary leak syndrome (SCLS) is an independent prognostic factor for poor sepsis outcome. We previously demonstrated that α1AMP-activated protein…”
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AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes by Balteau, Magali, Van Steenbergen, Anne, Timmermans, Aurélie D, Dessy, Chantal, Behets-Wydemans, Gaetane, Tajeddine, Nicolas, Castanares-Zapatero, Diego, Gilon, Patrick, Vanoverschelde, Jean-Louis, Horman, Sandrine, Hue, Louis, Bertrand, Luc, Beauloye, Christophe

“…Exposure of cardiomyocytes to high glucose concentrations (HG) stimulates reactive oxygen species (ROS) production by NADPH oxidase (NOX2). NOX2 activation is…”
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Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction by Menghoum, Nassiba, Beauloye, Christophe, Lejeune, Sibille, Badii, Maria Chiara, Gruson, Damien, van Dievoet, Marie-Astrid, Pasquet, Agnès, Vancraeynest, David, Gerber, Bernhard, Bertrand, Luc, Horman, Sandrine, Pouleur, Anne-Catherine

“…Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with high burden of comorbidities known to increase the mean platelet volume (MPV)…”
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Diabetic phenotype and prognosis of patients with heart failure and preserved ejection fraction in a real life cohort by Lejeune, Sibille, Roy, Clotilde, Slimani, Alisson, Pasquet, Agnès, Vancraeynest, David, Vanoverschelde, Jean-Louis, Gerber, Bernhard L, Beauloye, Christophe, Pouleur, Anne-Catherine

“…Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, with several underlying etiologic and pathophysiologic factors. The…”
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