Search Results - "BEARDSLEY, G. P"

Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma by GORLICK, R, HUVOS, A. G, HELLER, G, ALEDO, A, BEARDSLEY, G. P, HEALEY, J. H, MEYERS, P. A

“…In osteosarcoma, prognostic factors at diagnosis other than clinical stage have not been clearly identified. The aim of this study was to determine whether…”
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LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes by SHIH, C, CHEN, V. J, ANDIS, S. L, BEWLEY, J. R, RAYL, E. A, MOROSON, B. A, BEARDSLEY, G. P, KOHLER, W, RATNAM, M, SCHULTZ, R. M, GOSSETT, L. S, GATES, S. B, MACKELLAR, W. C, HABECK, L. L, SHACKELFORD, K. A, MENDELSOHN, L. G, SOOSE, D. J, PATEL, V. F

“…N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based…”
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A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis by Beardsley, G P, Moroson, B A, Taylor, E C, Moran, R G

“…5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than dihydrofolate reductase. DDATHF…”
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Functional consequences of the arabinosylcytosine structural lesion in DNA by Mikita, Thomas, Beardsley, G. Peter

“…Cytosine arabinoside (araC) is a potent antileukemic agent that is misincorporated into DNA in the course of its action. We have developed a chemical synthetic…”
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Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia by PLATT, O. S, ORKIN, S. H, DOVER, G, BEARDSLEY, G. P, MILLER, B, NATHAN, D. G

“…Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal hemoglobin production in anemic…”
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Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM by PIZZORNO, G, MOROSON, B. A, CASHMORE, A. R, RUSSELLO, O, MAYER, J. R, GALIVAN, J, BUNNI, M. A, PRIEST, D. G, BEARDSLEY, G. P

“…5,10-dideaza-5,6,7,8-terrahydrofolic acid (DDATHF) is a potent antiproliferative agent in cell culture systems and in vivo in a number of murine and human…”
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Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines by Pizzorno, G, Sokoloski, J A, Cashmore, A R, Moroson, B A, Cross, A D, Beardsley, G P

“…5,10-Dideazatetrahydrofolic acid (DDATHF) is a new potent antitumor agent that specifically inhibits purine biosynthesis, primarily through inhibition of…”
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5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines by PIZZORNO, G, CASHMORE, A. R, MOROSON, B. A, CROSS, A. D, SMITH, A. K, MARLING-CASON, M, KAMEN, B. A, BEARDSLEY, G. P

“…5,10-Dideazatetrahydrolic acid (DDATHF) is representative of a new class of antifolates acting through inhibition of de novo purine synthesis. We report here…”
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Lethality of Human Myeloblasts Correlates with the Incorporation of Arabinofuranosylcytosine into DNA by Major, P. P., Egan, E. M., Beardsley, G. P., Minden, M. D., Kufe, D. W.

“…We recently demonstrated a highly significant relationship between the incorporation of 1-β -D-arabinofuranosylcytosine (ara-C) into L1210 DNA and the loss of…”
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Novel blunt-end addition reactions catalyzed by DNA polymerase I of Escherichia coli by Clark, J M, Joyce, C M, Beardsley, G P

“…DNA polymerase I (Klenow fragment) of Escherichia coli catalyzes the addition of deoxynucleotides to 3' hydroxyl termini of blunt-ended DNA fragments. The…”
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Correlation of cytotoxicity with incorporation of ara-C into DNA by Kufe, D W, Major, P P, Egan, E M, Beardsley, G P

“…We have employed cesium sulfate density gradient analysis to monitor the incorporation of 1-beta-D-arabinofuranosylcytosine (ara-C) into L1210 cellular nucleic…”
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Accumulation of Methotrexate Polyglutamates, Ploidy and Trisomies of Both Chromosomes 4 and 10 in Lymphoblasts from Children with B-Progenitor Cell Acute Lymphoblastic Leukemia: a Pediatric Oncology Group Study by Whitehead, V. M., Vuchich, M. J., Cooley, L. D., Lauer, S. J., Mahoney, D. H., Shuster, J. J., Payment, C., Koch, P. A., Akabutu, J. J., Bowen, T., Kamen, B. A., Ravindranath, Y., Emami, A., Look, A. T., Beardsley, G. P., Pullen, D. J., Camitta, B.

“…Levels of accumulation of methotrexate polyglutamates were measured in vitro in lymphoblasts obtained at diagnosis from children with B-progenitor cell acute…”
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Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism by ROSOWSKY, A, GALIVAN, J, BEARDSLEY, G. P, BADER, H, O'CONNOR, B. M, RUSSELLO, O, MOROSON, B. A, DEYARMAN, M. T, KERWAR, S. S, FREISHEIM, J. H

“…Biochemical and biological studies have been carried out with 2-desamino-2-methylaminopterin (dmAMT), which inhibits tumor cell growth in culture but is only a…”
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Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin by Taylor, Edward C, Harrington, Peter J, Fletcher, Stephen R, Beardsley, G. Peter, Moran, Richard G

“…Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds…”
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Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis by Wilson, Ian A, Greasley, Samantha E, Horton, Patricia, Ramcharan, Joseph, Beardsley, G. Peter, Benkovic, Stephen J

“…ATIC, the product of the purH gene, is a 64 kDa bifunctional enzyme that possesses the final two activities in de novo purine biosynthesis, AICAR…”
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The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling by Bulock, Karen G, Beardsley, G Peter, Anderson, Karen S

“…5-Amino-4-imidazolecarboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC) is a bifunctional protein possessing two enzymatic activities that…”
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Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity by Vergis, J M, Bulock, K G, Fleming, K G, Beardsley, G P

“…The bifunctional enzyme aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) is responsible for catalysis of…”
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Chemical consequences of the incorporation of 5-fluorouracil into DNA as studied by NMR by Kremer, Alton B, Mikita, Thomas, Beardsley, G. Peter

“…The cytotoxic analogue of thymine, 5-fluorouracil (Uf), is known to be incorporated into DNA in biological systems. This abnormal base has been synthetically…”
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Modeling and molecular mechanical studies of the cis-thymine glycol radiation damage lesion in DNA by Clark, James M, Pattabiraman, Nagarajan, Jarvis, Wiley, Beardsley, G. Peter

“…Computer graphics and energy minimization techniques were used to construct a model of DNA containing cis-thymine glycol, an oxidation product of thymine…”
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Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis by LETVIN, N. L, LINCH, D. C, BEARDSLEY, G. P, MCINTYRE, K. W, MILLER, B. A, NATHAN, D. G

“…To determine the influence of cell cycle-specific agents on primate hematopoiesis and fetal hemoglobin production, two juvenile cynomolgus monkeys (Macaca…”
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