Search Results - "BEARD, Richard L"

Unique property of some synthetic retinoids: activation of the aryl hydrocarbon receptor pathway by Gambone, Carlo J, Hutcheson, Juliet M, Gabriel, Jerome L, Beard, Richard L, Chandraratna, Roshantha A S, Soprano, Kenneth J, Soprano, Dianne Robert

“…Potential pharmacological applications in the areas of oncology, dermatology, diabetes, and atherosclerosis of synthetic analogs of retinoic acid that target a…”
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Retinoic Acid Alters the Intracellular Trafficking of the Mannose-6-phosphate/Insulin-Like Growth Factor II Receptor and Lysosomal Enzymes by Kang, Jing X., Bell, Jennifer, Leaf, Alexander, Beard, Richard L., Roshantha A. S. Chandraratna

“…Previously, we showed that retinoic acid (RA) binds to the mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) with high affinity,…”
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Synthesis and Structure−Activity Relationships of Retinoid X Receptor Selective Diaryl Sulfide Analogs of Retinoic Acid by Beard, Richard L, Colon, Diana F, Song, Tae K, Davies, Peter J. A, Kochhar, Devendra M, Chandraratna, Roshantha A. S

“…Retinoids exert their biological effects by binding to and activating nuclear receptors that interact with responsive elements on DNA to promote gene…”
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Asymmetric synthesis of the corynantheine alkaloids via an intramolecular Blaise reaction. (-)-Corynantheidol and (-)-dihydrocorynantheol by Beard, Richard L, Meyers, A. I

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Synthesis and biological activity of retinoic acid receptor-α specific amides by Beard, Richard L., Duong, Tien T., Teng, Min, Klein, Elliott S., Standevan, Andrew M., Chandraratna, Roshantha A.S.

“…Retinoids are analogues of all- trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious…”
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Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents by STANDEVEN, Andrew M, THACHER, Scott M, YUAN, Yang-Dar, ESCOBAR, Maria, VULIGONDA, Vidyasagar, BEARD, Richard L, CHANDRARATNA, Roshantha A. S

“…Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not…”
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Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents 2 2Abbreviations: RARs, retinoic acid receptors; and RXRs, retinoid X receptors by Standeven, Andrew M., Thacher, Scott M., Yuan, Yang-Dar, Escobar, Maria, Vuligonda, Vidyasagar, Beard, Richard L., Chandraratna, Roshantha A.S.

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Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity by Beard, Richard L., Klein, Elliott S., Standeven, Andrew M., Escobar, Maria, Chandraratna, Roshantha A.S.

“…Retinoids are natural and synthetic analogues of the hormone retinoic acid. Systemic retinoid agonist therapy is usually associated with toxic side effects,…”
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Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells by HEMBREE, J. R, CHAPLA AGARWAL, BEARD, R. L, CHANDRARATNA, R. A. S, ECKERT, R. L

“…The hormones derived from vitamin A and related synthetic ligands (retinoids) are important regulators of differentiation and development and have been shown…”
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Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation by Thacher, S M, Standeven, A M, Athanikar, J, Kopper, S, Castilleja, O, Escobar, M, Beard, R L, Chandraratna, R A

“…Retinoid induction of epidermal hyperplasia was investigated in hairless mice with synthetic ligands for the retinoic acid (RAR) and retinoid X (RXR) nuclear…”
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Synthesis and Structure-Activity Relationships of Stilbene Retinoid Analogs Substituted with Heteroaromatic Carboxylic Acids by Beard, Richard L, Colon, Diana F, Gillett, Samuel J, Henry, Elizabeth, Marler, Deborah K, Song, Tae, Denys, Lydia, Garst, Michael E, Arefieg, Taghreed

“…Retinoids elicit biological responses by activating a series of nuclear receptors. Six retinoid receptors belonging to two families are currently known:…”
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Mitogenic effect of retinoid X receptor agonists in rat liver by Standeven, Andrew M., Escobar, Maria, Beard, Richard L., Yuan, Yang-Dar, Chandraratna, Roshantha A.S.

“…(E)-2-[2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-l-yl]-4-thiophenecar-boxylic acid (AGN 191701) and other retinoid X receptor…”
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Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid by Kochhar, Devendra M., Jiang, Heng, Penner, John D., Beard, Richard L., Chandraratna, Roshantha A.S.

“…Early events that initiate teratogenesis by Accutane ® or other retinoids in mammalian embryos remain unknown. It would be helpful for mechanistic…”
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Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids by Jiang, Heng, Penner, John D., Beard, Richard L., Chandraratna, Roshantha A.S., Kochhar, Devendra M.

“…One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the…”
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Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids by Beard, Richard L., Colon, Diana F., Klein, Elliott S., Vorse, Kimberly A., Chandraratna, Roshantha A.S.

“…Retinoids are hormones which activate two distinct families of nuclear receptors: the retinoic acid receptors (RAR α,β,γ) and the retinoid X receptors (RXR…”
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beta.-Hydroxy esters: (E)- versus (Z)-enolate geometry in dianionic Claisen rearrangements by Kurth, Mark J, Beard, Richard L

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Nucleophile-selective iodocyclizations: butyrolactone versus tetrahydrofuran formation by Kurth, Mark J, Beard, Richard L, Olmstead, Marilyn, Macmillan, James G

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Family Life Education as It Relates to the Extra-Curricular Program of the School by Beard, Richard L.

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Reading Habits and Interests by Beard, Richard L.

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The Teacher versus Counselor Controversy by Beard, Richard L.

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