Search Results - "BEACH, Jessica A"

Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer by Freimund, Alison E., MBBS, FRACP, Beach, Jessica A., PhD, Christie, Elizabeth L., PhD, Bowtell, David D.L., PhD

“…Resistance in ovarian cancer is driven by a range of mechanisms, some of which are therapy specific whereas others confer multidrug resistance. This review…”
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Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism by Aspuria, Paul-Joseph P, Lunt, Sophia Y, Väremo, Leif, Vergnes, Laurent, Gozo, Maricel, Beach, Jessica A, Salumbides, Brenda, Reue, Karen, Wiedemeyer, W Ruprecht, Nielsen, Jens, Karlan, Beth Y, Orsulic, Sandra

“…Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH…”
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Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination System by Wiedemeyer, W Ruprecht, Beach, Jessica A, Karlan, Beth Y

“…Resistance to platinum chemotherapy is one of the main factors driving ovarian cancer mortality, and overcoming platinum resistance is considered one of the…”
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A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer by CHEON, Dong-Joo, YUNGUANG TONG, KARLAN, Beth Y, ORSULIC, Sandra, SIM, Myung-Shin, DERING, Judy, BEREL, Dror, XIAOJIANG CUI, LESTER, Jenny, BEACH, Jessica A, TIGHIOUART, Mourad, WALTS, Ann E

“…To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer. Poor survival signatures from…”
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Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation by Liu, Zhenqiu, Beach, Jessica A, Agadjanian, Hasmik, Jia, Dongyu, Aspuria, Paul-Joseph, Karlan, Beth Y, Orsulic, Sandra

“…Abstract Objective Suboptimal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) is associated with poor survival but it is unknown if poor…”
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HOXB13 controls cell state through super-enhancers by Aspuria, Paul-Joseph, Cheon, Dong-Joo, Gozo, Maricel C., Beach, Jessica A., Recouvreux, Maria Sol, Walts, Ann E., Karlan, Beth Y., Orsulic, Sandra

“…Expression of the homeodomain transcription factor HOXB13 has been demonstrated in several malignancies but its role in tumorigenesis remains elusive. We…”
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Going to extremes: determinants of extraordinary response and survival in patients with cancer by Saner, Flurina A. M., Herschtal, Alan, Nelson, Brad H., deFazio, Anna, Goode, Ellen L., Ramus, Susan J., Pandey, Ahwan, Beach, Jessica A., Fereday, Sian, Berchuck, Andrew, Lheureux, Stephanie, Pearce, Celeste Leigh, Pharoah, Paul D., Pike, Malcolm C., Garsed, Dale W., Bowtell, David D. L.

“…Research into factors affecting treatment response or survival in patients with cancer frequently involves cohorts that span the most common range of clinical…”
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Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer by Beach, Jessica A, Aspuria, Paul-Joseph P, Cheon, Dong-Joo, Lawrenson, Kate, Agadjanian, Hasmik, Walsh, Christine S, Karlan, Beth Y, Orsulic, Sandra

“…Sphingosine kinase 1 (SPHK1), the enzyme that produces sphingosine 1 phosphate (S1P), is known to be highly expressed in many cancers. However, the role of…”
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Commentary on "Epithelial-to-Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer" by Beach, Jessica A, Bowtell, David D L

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ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma by Cheon, Dong-Joo, Li, Andrew J, Beach, Jessica A, Walts, Ann E, Tran, Hang, Lester, Jenny, Karlan, Beth Y, Orsulic, Sandra

“…ADAM metallopeptidase domain 12 (ADAM12) is a promising biomarker because of its low expression in normal tissues and high expression in a variety of human…”
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Correlation of glucocorticoid-mediated E4BP4 upregulation with altered expression of pro- and anti-apoptotic genes in CEM human lymphoblastic leukemia cells by Beach, Jessica A., Nary, Laura J., Hovanessian, Rebeka, Medh, Rheem D.

“…•An apoptotic pathway akin to C. elegans ces2–ces1–egl1 is evaluated in CEM cells.•E4BP4 does not alter BIM expression via SLUG/SNAIL repression.•PAR family…”
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Phenotypic Consequences of SLC25A40-ABCB1 Fusions beyond Drug Resistance in High-Grade Serous Ovarian Cancer by Pishas, Kathleen I., Cowley, Karla J., Pandey, Ahwan, Hoang, Therese, Beach, Jessica A., Luu, Jennii, Vary, Robert, Smith, Lorey K., Shembrey, Carolyn E., Rashoo, Nineveh, White, Madelynne O., Simpson, Kaylene J., Bild, Andrea, Griffiths, Jason I., Cheasley, Dane, Campbell, Ian, Bowtell, David D. L., Christie, Elizabeth L.

“…Despite high response rates to initial chemotherapy, the majority of women diagnosed with High-Grade Serous Ovarian Cancer (HGSOC) ultimately develop drug…”
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Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models by Morrish, Emma, Copeland, Anthony, Moujalled, Donia M., Powell, Jason A., Silke, Natasha, Lin, Ann, Jarman, Kate E., Sandow, Jarrod J., Ebert, Gregor, Mackiewicz, Liana, Beach, Jessica A., Christie, Elizabeth L., Lewis, Alexander C., Pomilio, Giovanna, Fischer, Karla C., MacPherson, Laura, Bowtell, David D.L., Webb, Andrew I., Pellegrini, Marc, Dawson, Mark A., Pitson, Stuart M., Wei, Andrew H., Silke, John, Brumatti, Gabriela

“…The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in clinical trials of acute…”
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Differential expression of argininosuccinate synthetase in serous and non‐serous ovarian carcinomas by Cheon, Dong‐Joo, Walts, Ann E, Beach, Jessica A, Lester, Jenny, Bomalaski, John S, Walsh, Christine S, Ruprecht Wiedemeyer, W, Karlan, Beth Y, Orsulic, Sandra

“…The current standard of care for epithelial ovarian cancer does not discriminate between different histologic subtypes (serous, clear cell, endometrioid and…”
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E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim by Beach, Jessica A, Nary, Laura J, Hirakawa, Yasuko, Holland, Eli, Hovanessian, Rebeka, Medh, Rheem D

“…Synthetic GCs serve as therapeutic agents for some lymphoid leukemias because of their ability to induce transcriptional changes via the GC receptor (GR) and…”
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Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer by Beach, Jessica A., Aspuria, Paul-Joseph P., Cheon, Dong-Joo, Lawrenson, Kate, Agadjanian, Hasmik, Walsh, Christine S., Karlan, Beth Y., Orsulic, Sandra

“…Sphingosine kinase 1 (SPHK1), the enzyme that produces sphingosine 1 phosphate (S1P), is known to be highly expressed in many cancers. However, the role of…”
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Abstract A65: Spatial characterization of drug resistance in ovarian cancer by Pishas, Kathleen I., Christie, Elizabeth L., Beach, Jessica A., Alsop, Kathryn, Freimund, Alison, Vashistha, Nidhi, Jhaveri, Niyati, Doolittle, Emerald, Wei, Wei, Zhang, Bingqing, Ma, Xiao-Jun, Bowtell, David D.L.

“…Abstract As we strive to prolong patient survival, the advent of targeted therapy for the treatment of ovarian cancer has significantly added to our…”
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Abstract B64: Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation by Liu, Zhenqiu, Beach, Jessica A., Agadjanian, Hasmik, Jia, Dongyu, Aspuria, Paul-Joseph, Karlan, Beth Y., Orsulic, Sandra

“…Abstract Suboptimal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) is associated with poor survival but it is unknown if poor outcome is due…”
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Abstract 2722: The genomic landscape of high-grade serous ovarian cancer in long-term survivors by Garsed, Dale W., Pandey, Ahwan, Fereday, Sian, Alsop, Kathryn, Wouters, Maartje C., Saner, Flurina, Beach, Jessica A., Milne, Katy, Kennedy, Catherine J., Hendley, Joy, Traficante, Nadia, Pearce, Celeste L., Pike, Malcolm C., Ramus, Susan J., Köbel, Martin, Nelson, Brad H., Goode, Ellen L., deFazio, Anna, Bowtell, David D.

“…Abstract Purpose: The majority of patients with high-grade serous ovarian cancer (HGSC) develop progressive disease following primary treatment, with a…”
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Abstract B09: Sphingosine kinase 1 (SPHK1) is a novel mediator of tumor-stroma interaction in ovarian cancer by Beach, Jessica A., Aspuria, Paul-Joseph, Cheon, Dong-Joo, Gozo, Maricel C., Karlan, Beth Y., Orsulic, Sandra

“…Abstract Sphingosine kinase-1 (SPHK1) is an enzyme that catalyzes the formation of the prosurvival second messenger sphingosine-1-phosphate (S1P) from the…”
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